1 J. Med. Chem, Manuscript ID: jm-2010-00117e, Revised version, March 16th, 2010
Trioxaferroquines as new hybrid antimalarial drugs François Bellot,1 Frédéric Coslédan,2 Laure Vendier,1 Jacques S. Brocard,3 Bernard Meunier,2 Anne Robert1* Supporting Information Scheme S1. MS fragmentation of trioxaferrocenes and trioxaferroquines. Figure S1. X-ray crystal structure of 9 (ORTEP view).
2 J. Med. Chem, Manuscript ID: jm-2010-00117e, Revised version, March 16th, 2010
Scheme S1. MS fragmentation of trioxaferrocenes and trioxaferroquines. O R
MS
N H
1, 8,
R
N H
O O m/z = 590.3 (MH+) m/z = 400.5 (MH+)
O
1a, m/z = 502.3 (MH+) 8a, m/z = 312.4 (MH+)
O MS
N
R
R
O O
2, m/z = 576.6 (MH+) 9, m/z = 386.5 (MH+) 4, m/z = 576.6 (MH+)
2a, m/z = 488.6 (MH+), 9a, m/z = 298.4 (MH+) 4a, m/z = 488.6 (MH+)
O
O O
R
O
N
MS
N H
R
O O 3, m/z = 618.6 (MH+), 10, m/z = 428.5 (MH+)
For 8-10,R =
N H
O
3a, m/z = 530.4 (MH+), 10a, m/z = 340.4 (MH+)
For 1-3, R =
For 4, R =
HN
HN
Fe
Fe Cl
Figure S1.
N
Fe Cl
N
X-ray crystal structure of 9 (ORTEP view).
