Tris-(hydroxymethyl)-aminomethane Derivatives. I ... - ACS Publications

I. Polyhydroxyamines1,2. J. Stanton Pierce, John Wotiz. J. Am. Chem. Soc. , 1944, 66 (6), pp 879–881. DOI: 10.1021/ja01234a010. Publication Date: Ju...
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TRIS-(HYDROXYMETHYL)-AMINOMETHANE DERIVATIVES : POLYHYDROXYAMINES 879

June, 1944

corresponding primary amines in good yields by methods involving the use of acidic solvents and palladium or platinum type catalysts. The hydrogenation with Raney nickel in the presence of ammonia, however, results in the

[CONTRIBUTION FROM T H E

formation of primary amines in nearly quantitative yields. Compounds hydrogenated include pyrimidine, piperidine, pyridine, thiazole and aliphatic basic nitriles. RENSSELAER,

DEPARTMENT OF CIIEMISTRY,

N. Y.

RECEIVED FEBRUARY 28, 1944

UNIVERSITY OF RICHMOND]

Tris- (hydroqmethyl)-aminomethane Derivatives. I. Polyhydroxyamines1.2 BY J. STANTON PIERCE AND Polyfunctional compounds are of particular interest as they afford opportunities for the synthesis of substances with varied properties, many of whlch are of practical importance. The ethanolamines have been found to be particularly useful, due to their solubility properties, ease of preparation and low cost. A large and interesting ,field for the synthesis of more highly polar amino alcohols than the ethanolamines was opened by the recent commercial synthesis of tris-(hydroxymethyl)-aminomethane, (HOCH&CNHs,' (A). In 1897, Piloty and Ruff5 prepared (A) by the reduction of tris-(hydroxymethy1)-nitromethane which had been prepared two yeqs previously by Henry,6 by the reaction of nitromethane apd formaldehyde Various investigators have combined two primary or secondary amino groups by reaction with epichlorohydrin,' a,w-dihalohydrins8 or a,w-dihalogenalkanes.Y This paper takes up the synthesis of polyhydroxyamines by the union of two molecules of (A), mainly through methylene or methylene and hydroxymethylene groups, b3 the union of (A) with other amino alcohols through methylene and hydroxymethylene groups, and by the alkylation of (A) with chlorohydrins. A subsequefit paper will take up the preparation of alkyl and alkaryl derivatives of (A). The symmetrical polyhydroxydisecondary amines described in this paper usually were prepared by heating (A) with an apdihalide, in most cases the bromide. The reactions were carried out under reflux, with no solvent or with alcohol as solvent, and in sealed tubes, with alcohol as solvent. The asymmetrical diamines, all, of

.

(1) Acknowledgment is made to Dr. E. Emmet Reid, Research Adviser to the Chemistry Department of the University of Richmond, for his advice in this work. (2) This research was misted by a grant from Chas. C. Haskell and Co., Inc., Richmond, Va. (3) Taken from the thesis submitted by John Wotiz in partial fulfillment for the degree of Master of Science. Present address, Depertment of Chemistry, The Ohio State University, Columbus, Ohio. (4) C. L. Gabriel, Ind. En& Chem.. 88, 891 (1940). (5) 0. Piloty and 0. RUE, Bcr., 80, 1666, 2062 (1897). (6) Henry, Bull. soc. chim., 131 18, 1001 (1895). (7) 0. Eisleb, U. S. Patent 1,790,042 (1931); Grogginr and Stirton, I n d . Enp. Chem., 49, 1869 (1987). (8) J. F. O h , U. S. Patent 2,041,611 (1936); V. Kartadaoff, U. 9. Patmat 2,149,127 (1989). (9) I. 0. F.rbcnhdWtd@45. 0 1 8 I)rlt*h PS-t (49,718 (1987).

JOHN

WOTI~

which are derivatives of 2-propanol, were prepared by treating a secondary amine with epichlorohydrin a t a temperature not exceeding 30' and by the reaction of the product thus formed with (A) a t elevated temperature, with alcohol as solvent. Also, two molecules of (A) reacted with epichlorohydrin, to form a symmetrical derivative. Monoalkylation products of (A) were prepared by reaction with halohydrins. The greatest difficulty in the preparation of the polyhydroxyamines described in this paper was their isolation and purification. Since the free bases, as obtained, showed no tendency to crystallize, they were converted to hydrobromides or hydrochlorides for identification and analysis. A typical mixture in the preparation of a symmetrical disecondary amine likely contained dihalide, (A), the monoalkylation product of (A) and the desired disecondary amine, the latter three compounds being present both as the free bases and as the halogen acid salts. Usually, excess halogeff acid was added to convert all of the free bases to their salts. The unreacted alkylene dihalide was removed by evaporation or extraction with ether. Finally, purification was effected by fractional crystallization or by selective extraction with two solvents, evaporation of the solvent, if necessary, and trituration of the oily residue with alcohol or acetone or a mixture of the two solvents. Since this purification involved so much loss of material, the yield is given only in the case of 1,3bis- [tris- (hydroxymethyl)-methylamino]-2 -propanol, the compound which was studied most. fully. The polyhydroxyamines described in this paper are characterized by their very high water solubility, both as the free bases and in the form of their salts with hydrochloric or hydrobromic a.cid. Some of these derivatives of (A) have a great tendency to hold ferric hydroxide, bismuth hydroxide and some other metallic hydroxides in solution. The solubilizing action of the derivatives of (A) is being studied with the view to technical and pharmaceutical applications and will be reported elsewhere. Each of these compounds has one or two secondary amino groups. The high proportion of hydroxyl grou and likely their spatial rurangcment -ea &dt some of the reactions

J. STANTONPIERCE AND JOHN WOTU

880

Vol. 66

and treatment with anhydrous acetone. Finally, by evaporation of the oily lower layer, the free base was obtained as an oil. Calcd for CUH&NZ: nitrogen, 0.40. Found: N, 9.41. l-Diethanolam.ino3-tris-(hydroxymethy1)-metbylamino2-propanol Dihydrochloride, (HOCHI(!H9)2NCHnCHOHCH*NHC(CHsOH),.2HCl.-A mixture of 10.5 g. of diethanolamine (0.1 mole) and 9.5 g. of epichlorohydrin (0.1 Experimental mole) was stirred well, the temperature being kept around 1,3-Bis- [-ti+-( hydrolymethy1)-methylamino]-propane 30". After the initial exothermic reaction ceased, the mixDih drobromide, (HOCHl)&NHCH,CH~CH~NHC( CHI- ture was left overnight at room temperature. The clear OH{r2HBr.-A solution of 24 g . of (A) (0.2 mole) and 10 viscous liquid was extracted with ether. The ether ing. of-trimethylene bromide (0.0drnole) in 150 ml. of alcohol solirble product was added to 12 g. of (A) (0.1 mole) and was heated under reflux on a water-bath for six hours. 50 ml. of alcohol and the mixture was heated under r d u x On standing overnight, needle-like crystals of (A).HBr for six hours on a water-bath. The reaction mixture wa3 were formed. These crystals were filtered off and the acidified with concentrated hydrochloric acid. An oil was filtrate was made distinctly acidic with hydrobromic acid. thrown out by the addition of absolute alcohol, acetone The acidic solution was evaporated to low volume to re- and ether. This oil was converted to a semi-solid by solumove most of the water. The gummy residue was dis- tion in aqueous alcohol, treatment with anhydrous acetone solved in hot absolute alcohol and the solution was treated and by allowing the lower layer, after evaporation, to with an equal volume of anhydrous acetone. Two layers stand in a vacuum desiccator. Finally, purification was were formed. The lower layer was separated and triturated effected by extraction with hot absolute alcohol. with a mixture of equal volumes of absolute alcohol and 1,3-Di-(diethanolamino)-2-propanol DihydrochloAde, anhydrous acetone; until crystalline. The solid, 1,3-bis- (HOCHaCHz)rNCHtCHOHCH*N(CHaCH*OH)a*2HCl.[tris (hydroxymethyl) - methylamino] -propane dihydro- The condensation product of diethanolamine and epibromide, on three recrystallizations from alcohol, melted chlorohydrin was prepared to compare it with the product at 170-171'. formed by the reaction of epichlorohydrin with one mole1,2-Bie- [trip-( hydroxymethy1)-methylamino]-ethane Di- cule each of diethanolamine and (A). hydrobromide, (HOCHZ)*CNHCH2CH~NHC(CH,OH)r2-10.5 g. of diethanolamine (0.1 mole) and 9.3 g. of epiHBr.-This product was made and purified by practically chlorohydrin (0.1 mole) were mixed by shaking and cooling the same procedure as the compound above. below 30". After the exothermic reaction ceased, a clear I,&Bis- [tris-(hydroxymethylpmethylamino]-hexaneDi- viscous liquid resulted. An additional 10.5g. of diethanolhydrobromide, ( HOCHpjrCNH(CHahNHC( CH$OH)t.2- amine was added and the liquid was heated on a waterHBr.-A mixture of 48.4 g. of (A) (0.4 inole) and 24.4 g. of bath for eight hours. The product then was acidified hexamethylene bromide (0.1 mole) was refluxed with with concentrated hydrochloric acid and was extracted mechanical stirring until a homogeneous mixture was ob- with acetone. The lower layer was recrystallized from tained. The brown glue thus formed was dissolved by absolute alcohol. rehxing with 300 ml. of 95% alcohol. The alcoholic I-Ethvlethanolamino-3-tris-~ hvdroxvmethvlbmethv1solution was made strongly acidic with hydrobromic acid and most of the alcohol was evaporated. The residue was treated with absolute alcohol and anhydrous acetone to an01 was treated with an equimolar quaniity of epiyield crystals of impure (A).HBr, melting at 128-132". chlorohydrin a t a temperature below 30'. After the exoThe filtrate was treated with three volumes of anhydrous thermic reaction ceased, the viscous liquid was left at room acetone. An oily layer was formed. This lower layer was temperature overnight. The condensation product thus triturated with absolute alcotiol and anhydrous acetone, formed was heated with an equimolar amount of (A) for yielding a solid melting at 150-155'. On recrystallization eight hours on a water-bath and the mixture was acidified from 96% alcohol and anhydrous acetone, the product with hydrochloric acid. Repeated attempts to recrystalmelted at 160.5-162'. lize from alcohol failed to yield a solid but the light pink 1,3-Bis- [tris-( hydroxymethyl)-methylamino]-2-propanol colored g1,ue analyzed satisfactorily. Dihydrochloridt?, (HOCHa)&NHCHsCHOHCHiNHCy,y -Bm-[tris-( hydroxymethy1)-methylamino] -propyl (CHnOH)r2HC1.-Glyceroldichlorohydrin was heated with Ether Dihydrochloride, (HOCHI)*CNHCHZCH~CH~OCH,two molar quantities of (A)'at 100' for three hours with CH;CHsNHC(CH~OH)~.2HCl.-A mixture of 17 g. of no solvent and with frequent stimng. The yellow glue y , y -dichloropropyl ether (0.1 mole) and 24 g. of (A) (0.2 formed was dissolved in hot alcohol and the solution was mole) in 100 ml. of alcohol was heated in a sealed tube acidified with hydrochloric acid. The precipitate which overnight at 110". The alcoholic solution was acidified formed, on cooling, was recrystallized from aqueous alcohol. with hydrochloric acid and the precipitated (A).HCl was Better results were obtained by the following procedure: filtered off. Repeated evaporations, solution in absolute 242 g. of (A) (2.0 moles) and 92.5 g. of epichlorohydrin alcohol, treatments with anhydrous acetone and finally (1.0 mole) were mixed with 200 ml. of alcohol and heated treatments with anhydrous ether were necessary to remove on a boiling water-bath under re5ux for five hours. The all of the (A).HCl. The oil. finally obtained analyzed viscous brown liquid was treated with 100 ml. (appreci- slightly low for y,r'-bis-[tris-(hydroxymethy1)-methylable excess) of concentrated hydrochloric acid, with amino]-propyl ether dihydrochloride. stirring. The reaction mixture was cooled and filtered with suction. On one recrystallization from an alcohd< ~ ~ + ( C H 9 0 H ) . . HC1, 4-Tris-(hydroxymethy1)water solution, there was obtained 190 g. (61%) of the d i h y d r d o r i d e of 1,3-bis-[tris-(hydroxymethyl)-methylamino]9-propanol, m. p. 186-187'. methylmorpholme Hydrochloride.-Fourteen grams of I ,3-Bik [trio-(hydror3methpl)-methylamiuo -2-propan01, B,B'dichloroethyl ether (0.1mole) and 24 g. of (A) (0.2 ( H O ~ l ~ ~ ~fire mole) H were ~ heated ~ withl100 ml.~of alcohol ~ in a ~sealed tube H ~ base, mixed with a httle sodium chloride, was prepared by Overnight at 150". On cooling, snow-white crystals of treatment of the dihydrochloride, in methyl alcohol, with (A)*HCI were formed. The crystals were filtered off and the calculated quantity of sodium methylate, refluxing, the filtrate was acidified with hydrochloric acid. On iiltering and evaporating the methyl alcohol solution. partial evaporation, a solid was obtained. @I recrystdAlso, the free base, free of inorganic impurities, was ob- lization from alcohol, the 4-tris-(hydroxymethyl)-methyltained from the dihydrochloride by prolonged heating of morpholine hydrochloride melted at 184-185". Calcd. an aqueous solution with excess silver carbonate, removal for CsH~0fiCl: C1.16.67. Found: CI, 16.69. of dissolved silver with hydrogen sulfide and removal of A further concentration of the original atrate yielded c o l d impurities by repeated solution in absolute alcohol other WO?S of -bib, likely mpinlg (A)*HCI, judghg

of amino nitrogens. However, in some cases it is possible to get an amino group to react and a study is being made to utilize these polyhydroxyamines for the preparation of various polyfunctional compounds.

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June, 1944

CLEAVAGE OF

(DIALXYLVINYL)-ALKYLCYANOACETIC ESTRRS BY SODIUM ALKOXDbES 881 TABLE I POLYRYDROXY AMIN E HYDRORALIDES Empirical formula

Compounds

M. p., OC.

uncor.

Halogen anal res % Calcd. %ouidb

(HOCHn)sCNHs*HCI' (HOCH&CNHvHBr" (HOCHa)8CNHCH2CHiNHC(CH20Hs).2HBr (HOCH&CNH(CH&NHC( CH*OH)s4HBr (HOCHz)sCNH(,CHt)rNHC(CHzOH)c2HBr (HOCHn)sCNHCHzCHOHCHnNHC( CHzOH)a*2HCI (HOCHn)sCNHCH~CHOHCH,"C( CHzOH)s.2HBr

CrHirOiClN 149-150 22.50 22.58 GH1208BrN 133-134 39.55 39.52 37.16 37.09 C~dIasosBrrN~ 205-206 35.98 35.25 CIIHZSO~B~~N 170-171 I 32.87 32.10 CirHsrOoBraNn 160.5-162 C~1HnaO~CIlNi 186-188 19.10 19.07 C11H&7Br2N~ 160-162 34.73 34.67 20.90 20.97 CiiHzsOsClzN2 98-100 (HOCHrCHz)zNCHzCHOHCHzN(CH:CH~0H)n~2HCl CiiHzsOsCliNt 139-141 19.96 19.55 (HOCH~CHz)zNCHzCHOHCHzNHC(CH~OH)s*2HCl Sirup 20.90 19.74 CliHnsOsClaNs fHOCHzCHz)(CzHs)NCHzCHOHCHiNH(CH,OH)r*2HCl HOCHzCHOHCHzNHC(CH20H)s.HCI C7Hl.g06CIN Sirup 15.31 14.90 HOCHzCHJ'iHC( CH20H)saHCI CeHlsOdYN Sirup 17.58 17.30 C7H1804BrN Sirup 30.72 30.18 HOCH1CH2CHzNHC(CH,OHh.HBr ClrHsr07Cl~N, Sirup 17.16 16.30 (HOCHa)aCNH(CHz)aO(CHZhNHCf CHzOH)&HCI Compounds given for reference. We are indebted to E. E. Bowden and Walter W. Haden for mast of the halogen analyses in this work. from the melting points. No &@'-bis-[tris-(hydroxy- The sirup, while hot, was placed in a vacuum desiccator. After two days of drying, a satisfactory analysis for methyl)-methylamino]-ethyl ether was isolated. 1,Z-Dihydroxy-3-tris-( hydroxymethy1)-methylaminopro- chloride was obtained. pane Hydrochloride, HOCHzCHOHCH2NHC(CHyOH)8. Similar procedures were used for the reaction of ethylene HCL-A mixture of 24 g. of ( A ) (0.2 mole) and 11 g. of chlorohydrin and trimethylene bromohydrin with (A) and glycerol monochlorohydrin (0.1 mole) was heated under for purification of the products formed. reflux with 50 ml. of alcohol for five hours. The resulting liquid was acidified with hydrochloric acid, while hot. Summary On cooling, crystals of (A).€€CIwere obtained and filtered A series of highly polar polyhydroxyamines off. More (A).HCl was obtained by concentration of the filtrate and treatment with dry acetone. This process have been made from tris-(hydroxymethy1)was repeated until no crystals were obtained. The solu- aminomethane. tion then was concentrated to a sirup which was completely miscible with absolute alcohol and dry acetone. RICHMOND, VA. RECEIVEDJANUARY 18, 1944

[CONTRIBUTION FROM THE CHEMICAL LABORATORY OF BRYN MAWRCOLLEGE]

The Cleavage of (Dialkylviny1)-alkylcyanoacetic Esters by Sodium Alkoxides' BY ELIZABETH hf. OSMANAND ARTHURC. COPE

More or less extensive cleavage of (dialkyl- investigators.8 The reaction proceeds readily at vinyl)-alkylcyanoacetic esters to unsaturated moderate temperature with disubstituted esters nitriles has been observed to occur as a side re- such as I which contain an a,b-unsaturated (elecaction during condensation of the esters with urea tron attracting, or negative) group. Malonic in the presence of sodium alkoxides.* This paper ester derivatives which are not labilized by elecreports an investigation of the cleavage reaction, tron attracting substituents axe cleaved in a simiand its use in the preparation of certain a,b- lar manner at higher temperatures." unsaturated nitriles. The hydrolysis of the Kandiah and Linstead4 have proposed a reiiitriles to acids has also been studied. action mechanism for the cleavage in which the The products of cleavage are ethyl carbonate carbethoxyl group is removed by combination and an a,p-unsaturated nitrile with ethoxide ion as ethyl carbonate, forming the .anion of the nitrile. This ion acquires a R'CH=C( R')>