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Ultrasmall WS2 Quantum Dots with Visible Fluorescence for Protection of Cells and Animal Models from Radiation-induced Damages Xueting Bai, Junying Wang, Xiaoyu Mu, Jiang Yang, Haixia Liu, Fujuan Xu, Yaqi Jing, Lingfang Liu, Xuhui Xue, Haitao Dai, Qiang Liu, Yuan-Ming Sun, Changlong Liu, and Xiao-Dong Zhang ACS Biomater. Sci. Eng., Just Accepted Manuscript • DOI: 10.1021/acsbiomaterials.6b00714 • Publication Date (Web): 30 Jan 2017 Downloaded from http://pubs.acs.org on January 31, 2017
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ACS Biomaterials Science & Engineering
Ultrasmall WS2 Quantum Dots with Visible Fluorescence for Protection of Cells and Animal Models from Radiation-induced Damages Xueting Bai a, Junying Wang a, Xiaoyu Mu a, Jiang Yang b, Haixia Liu a, Fujuan Xu a, Yaqi Jing a, Lingfang Liu a, Xuhui Xue c, Haitao Dai a, Qiang Liu c, Yuan-Ming Sun c, Changlong Liu a, * and Xiao-Dong Zhang a, d,* a
Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology,
Institue of Advanced Materials Physics, School of Sciences, Tianjin, 300350, China b
Environment, Energy and Natural Resources Center, Department of Environmental Science
and Engineering, Fudan University, No.220, Handan Road, 200433, China c
Tianjin Key Laboratory of Molecular Nuclear Medicine, Institute of Radiation Medicine,
Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300192, China d
Tianjin Collaborative Innovation Center of Chemical Science and Engineering, Tianjin
300072, China.
Correspondence should be addressed to X.Z. (
[email protected]) C.L. (
[email protected]),
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ACS Biomaterials Science & Engineering
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Abstract: Two dimensional WS2 materials have attracted wide attention in condensed physics and materials science due to its unique geometric and electronic structures. Particularly, WS2 shows extraordinary catalytic activities when its size decreases to ultrasmall, which provides potential opportunities for medical applications. In this work, WS2 quantum dots with strong catalytic properties were used for in vitro and in vivo protection from ionizing radiation induced cell damages. WS2 quantum dots possess unique optical properties of blue photoluminescence emission and excitation-wavelength dependent emission profiles. In vitro studies showed that cell viability can be considerably improved and cellular reactive oxygen species (ROS) can be removed by WS2 quantum dots. In vivo studies showed WS2 quantum dots can effectively protect the hematopoietic system and DNA from damages caused by high-energy radiation through removing whole-body excessive ROS. Furthermore, WS2 quantum dots showed nearly 80% renal clearance within 24 h post injection and did not cause any obvious toxicities in up to 30 days after treatment.
Keywords s: WS2 quantum dots, Excitation-wavelength dependent fluorescence, Radiation protection, Renal clearance, Reactive oxygen species
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ACS Biomaterials Science & Engineering
1. Introduction Two dimensional WS2 materials have received wide interest in the post-graphene era due to their controllable band gaps and remarkable optical and electronic properties.1-2 Owing to higher special surface area and more active edge sites, ultrasmall WS2 quantum dots usually show higher catalytic activities than regular nano-sized WS2 particles.3 Especially, ultrasmall WS2 quantum dots (
