Article pubs.acs.org/crystal
Understanding the Origins of Conformational Disorder in the Crystalline Polymorphs of Irbesartan Sean P. Delaney,† Duohai Pan,‡ Michael Galella,‡ Shawn X. Yin,‡ and Timothy M. Korter*,† †
De partment of Chemistry, Syracuse University, 1-014 Center for Science and Technology, Syracuse, New York 13244-4100, United States ‡ Drug Product Science & Technology, Bristol-Myers Squibb, 1 Squibb Drive, New Brunswick, New Jersey 08903, United States S Supporting Information *
ABSTRACT: The characterization of crystalline polymorphs of drug molecules is an area of great interest since these variations in solid-state structure directly influence the physical properties of such substances. Terahertz spectroscopy provides a powerful analytical tool for these investigations and has been used here to study tautomeric polymorphism and conformational disorder in crystallized irbesartan, an antihypertensive medication. The low-frequency (
