Use of 1HN-1HN NOEs to Determine Protein ... - ACS Publications

May 22, 1995 - cutoff distance is increased to 7 Б, the calculated structures begin to approximate the fold of profilin reasonably well. The. C-termi...
0 downloads 0 Views 310KB Size
J. Am. Chem. SOC. 1995,117, 9592-9593

9592

Use of 'HN-~HN NOEs To Determine Protein Global Folds in Perdeuterated Proteins Ronald A. Venters,' William J. Metzler,* Leonard D. Spicer,*95 Lucian0 Mueller,* and Bennett T. Fanner II*,t

Duke University NMR Center and Departments of Biochemistry and Radiology, Duke University Medical Center, P.O. Box 3711, Durham, North Carolina 27710 Bristol-Myers Squibb Pharmaceutical Research Institute P.O.Box 4000, Princeton, New Jersey 08543-4000 Received May 22, 1995 NMR structural studies on isotopically unlabeled proteins are typically limited to those with