Editorial Cite This: ACS Chem. Neurosci. 2018, 9, 2097−2098
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What Papers Are People Citing and What Are People Reading?
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to depression. This is an important topic and generating a great deal of buzz. Also, this is a key consideration for discovery projects that might use this as a PD model in a depression program.
s 2018 is rapidly coming to a close (where did this year go?), it is a good time to reflect on ACS Chemical Neuroscience and survey which papers have been the most read in 2018, and which papers are receiving the most citations. Both are key measures of impact, even though only citations count in the annual impact factor. According to Web of Science,1 two 2016 papers lead the list for most cited in 2018. The most cited paper in 2018, that was published in 2016, is a Review by Albrecht and co-workers entitled “In Vivo Imaging of Neuroinflammation” (DOI: 10.1021/acschemneuro.6b00056). Here, the authors provide brief descriptions of currently available neuroimaging methods (PET, SPECT, and MRI) to image neuroinflammation in the human central nervous system (CNS) in vivo. This is a phenomenal review and definitely worth reading.
The second most cited paper thus far in 2018 (that was published in 2017) is from Derreumaux and co-workers in a Viewpoint piece entitled “Why Is Research on Amyloid-β Failing to Give New Drugs for Alzheimer’s Disease?” (DOI: 10.1021/acschemneuro.7b00188). Here the authors review recent data from the literature, and their own laboratories, and offer some possible explanations as to why so many therapies targeting Αβ reduction are failing in human clinical trials. This is very poignant piece that should be read by all working in the Alzheimer’s disease field.
The second most cited paper thus far in 2018 (that was published in 2016) is from Wager and co-workers at Pfizer (DOI: 10.1021/acschemneuro.6b00029), detailing real world drug discovery applications of the CNS MPO scoring algorithm entitled “Central Nervous System Multiparameter Optimization Desirability: Application in Drug Discovery.” Embedded in the HTML version of this paper is a CNS MPO calculator. For those that employ in silico driven decision making, this is a must read.
In 2018, a combination of Review and Viewpoint pieces have emerged as the most cited papers by the readership of ACS Chemical Neuroscience. I think it is very interesting when one considers the breadth of topics that fall into the most cited (neuroimaging, in silico parameters for CNS penetration, a new view on a classical rat behavioral model, and, finally, thoughts on why drugs targeting Αβ are failing in man). Kudos to these authors for writing exceptional manuscripts, for stimulating scientific thought/debate, and for publishing with ACS Chemical Neuroscience. On the other side, I feel highly read papers are also of tremendous impact, even if they are not the most cited. There
The most cited paper in 2018, that was published in 2017, is a Review by Commons and co-workers entitled “The Rodent Forced Swim Test Measures Stress-Coping Strategy, Not Depression-like Behavior” (DOI: 10.1021/acschemneuro.7b00042). Here, the authors review evidence that argues a more thoughtful consideration of the forced swim test, to expand to include the study of stress and disorders characterized by altered response to stress, not solely limited © 2018 American Chemical Society
Published: September 19, 2018 2097
DOI: 10.1021/acschemneuro.8b00438 ACS Chem. Neurosci. 2018, 9, 2097−2098
ACS Chemical Neuroscience
Editorial
are dozens of papers that have been downloaded and read from the ACS Chemical Neuroscience webpage thousands of times many exceeded 5000 reads!2 Clearly, papers in this category are influential and of great interest to the Journal’s readership (and can be found under the “most read” tab). Over the past 12 months, four papers stand out as being highly downloaded and read. First, a terrific Review by Tonge (DOI: 10.1021/ acschemneuro.7b00185) was the most read over the past 12 months (7407 times), and introduces the potential benefits of drug-target kinetics, e.g., the ability to delineate both thermodynamic and kinetic selectivity. The Review also touches on a mechanistic PK/PD model that integrates drug−target kinetics into predictions of drug activity. Overall, some great food for thought on how we approach drug discovery and chemical optimization.
science. Kudos to these contributors as well, for the impact and interest their submissions have had on the readership of the Journal. The ACS provides multiple avenues to get your work noticed, read, and cited. I welcome you Articles, Letters, Reviews, Perspectives, Viewpoints, and ideas for future special issues and/or guest editorials. Will your next submission to ACS Chemical Neuroscience become one of Legend?
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Craig W. Lindsley, Editor-in-Chief AUTHOR INFORMATION
ORCID
Craig W. Lindsley: 0000-0003-0168-1445
Second, an Editorial by yours truly entitled “New 2016 Data and Statistics for Global Pharmaceutical Products and Projections through 2017” (DOI: 10.1021/acschemneuro.7b00253) was the most read (viewed over 7322 times), and continued our annual series detailing the top selling drugs in the previous year (2016), the top therapy classes and commenting on trends in the industry (e.g., biologics vs, small molecule therapeutics). Next, another of my Editorials, this one entitled “Chronic Traumatic Encephalopathy (CTE): A Brief Historical Overview and Recent Focus on NFL Players” (DOI: 10.1021/acschemneuro.7b00291) scored big with our readers (viewed over 4122 times). This was more of a “torn form the headlines” prompted editorial, reviewing historical and recent data around CTE, and suggesting additional studies that need to be performed to tighten up cause and effect correlations.
Notes
Views expressed in this editorial are those of the author and not necessarily the views of the ACS.
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REFERENCES
(1) See http://apps.webofknowledge.com/Search.do?product= WOS&SID=6AFgS48l5fCrjRz7ITf&search_mode= GeneralSearch&prID=146d6a2b-1c27-4d3c-901d-e3833c72c9dc. (2) See https://pubs.acs.org/journal/acncdm.
Finally, a Perspective by de la Fuente-Nunez, Lu, and coworkers entitled “Neuromicrobiology: How Microbes Influence the Brain” (DOI: 10.1021/acschemneuro.7b00373) was popular, garnering over 3676 views. Here, the authors provide a detailed overview of the complex interactions between gut microbiota and the central nervous system. This a very hot topic of late, and we are happy to have the definitive review on the area published in ACS Chemical Neuroscience. Once again, the breadth of topics that fall into the most read/viewed papers is expansive and further highlights the diverse range of content published in ACS Chemical Neuro2098
DOI: 10.1021/acschemneuro.8b00438 ACS Chem. Neurosci. 2018, 9, 2097−2098
