employment outlook MERCK & CO.
OPPORTUNITIES FOR 2014 AND BEYOND
TEAMWORK
Kress (from left), Erik Regalado, and Melodie Christensen collaborate on the design of a high-throughput screening experimental run.
WHAT PHARMA WANTS Drug firms’ chemistry leaders describe the educational training that they seek in NEW RECRUITS SUSAN J. AINSWORTH, C&EN DALLAS
THE INHOSPITABLE employment climate
has spared few sectors in the chemical sciences, but those who aspire to work in the pharma and biotech industries continue to face a particular challenge in landing a job. In the wake of massive layoffs in the U.S., “much of the chemistry work in the pharmaceutical industry has been outsourced overseas,” observes Lauren Celano, founder and chief executive officer of Propel Careers, a Boston-based life sciences search and career development firm. “It’s especially tough for chemists just leaving school to find work. It is certainly very different from the way it was 10 years ago,” when many more graduates had an offer in hand. In response to these challenges, some
universities are stepping up their game, looking for new ways to help their students gain an edge in the job market. “Today, universities are no longer working solely to educate students broadly in terms of their general education and specifically in terms of their major, but they are also striving to better prepare them for success in the workplace,” says Moses Lee, program director of the research and science grants program at the M. J. Murdock Charitable Trust in Vancouver, Wash. As chemistry educators, “it is imperative that we change our business as usual— MORE ONLINE CEN.ACS.ORG
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which includes the way we teach—so that our students have a better chance to get the jobs that they want,” says Scott M. Auerbach, a professor of chemistry at the University of Massachusetts, Amherst. Taking an active stance on this issue, he helped develop and is director of the university’s Integrated Concentration in Science (iCons) program, which helps science students develop the multidisciplinary skills needed to excel in industry. Meanwhile, other chemistry professors—influenced by the dynamics of the job market—are pondering changes in
Explore the iCons program at UMass, Amherst, and ACS unemployed member benefits at http://cenm.ag/pharmajob. MAY 26, 2014
EMPLOYMENT OUTLOOK
their own curricula. “I’m concerned about chemistry education and how it should be tailored to the needs of industry, especially the highly competitive pharma field,” says Kevin Burgess, a professor of chemistry at Texas A&M University. To help provide insight into those needs, C&EN queried a sampling of sources who are involved in hiring chemists into pharma-focused companies. That panel includes Christopher Hill, vice president of discovery chemistry at Merck & Co.; John W. Kozarich, chairman and president of ActivX Biosciences in La Jolla, Calif.; Michael H. Kress, vice president of process and analytical chemistry at Merck & Co.; Alan D. Palkowitz, vice president of discovery chemistry and technologies at Eli Lilly & Co.; Bruce Roth, vice president of discovery chemistry at Genentech; and William C. Shakespeare, vice president of drug discovery at Ariad Pharmaceuticals in Cambridge, Mass. Their responses—which reflect some difference of opinion—certainly cannot be generalized for all companies. However, these sources highlight specific skills, knowledge, and experience that at least some pharma-focused companies covet, and their input may help universities finetune their offerings to better prepare their students to crack the code for landing those precious few pharma jobs.
Increasingly, new grads are too focused on memorization and knowing the “right answer,” which may stem from students’ rigorous preparation for SAT tests or other standardized exams. Universities have a great opportunity to address this issue at the undergraduate level.
At the bachelor’s and master’s degree levels, what are the key courses that you want universities to teach their chemistry students? Roth: We want the B.S.-level chemists
successfully completed very companion scientific disciplines INNOVATIVE At Ariad, Shakespeare to effectively advance hypothechallenging research projects. (back) and Feng That work does not have to be sis-driven drug discovery. Li, a principal something as complex as a total scientist, take a synthesis of a natural product, Outside of chemistry, what targeted approach to designing new for example, but we like people other kinds of courses should small-molecule with that background. We also students take to be equipped cancer medicines. hire people who completed work to work at your company? that was more methodology Shakespeare: We see too focused. In any case, we want many candidates who are unfapeople who are innovative and can indemiliar with basic biology or biochemistry pendently approach and solve problems. core concepts that I think are essential for Hill: We are looking for candidates who a career in drug discovery. Especially at the have taken courses that give them a strong Ph.D. level, you have to have a fundamengrounding in the properties of molecules, tal understanding of what a cell is, how it how to make them, and the way they interfunctions, and what it means when we talk act with other molecules. If they have that about things like signal transduction. It is basic knowledge, we can help train them important for students to take at least one and hone them to our desired needs. course that teaches these basic concepts. Kress: We want to hire chemists who Palkowitz: I would like to see chemists have a deep understanding of core chemhave greater exposure to courses that proistry principles, which include thermodyvide a background in protein structure and namics, physical organic chemistry, and function. This serves as the backdrop for kinetics. Taking courses in these areas is many of the problems chemists will study paramount to success moving forward. throughout their careers. Additionally, any Palkowitz: We hire Ph.D. scientists course that would provide an introduction
we hire into discovery chemistry to have completed higher-level organic chemistry courses, such as theoretical organic chemistry and physical organic chemistry. These courses help them gain a deeper understanding of the theory behind both synthetic and medicinal chemistry and give them more hands-on laboratory experience. If undergrads are able to take courses to get some exposure to biochemistry so they understand enzymatic reactions or receptor pharmacology, they will have a leg up, but it’s not essential. Most of all, we want to see that candidates have an ability to design synthetic routes, troubleshoot, and understand the underlying mechanisms of reactions. Shakespeare: There needs to be more emphasis on classes that will help develop more creative and innovative problem solvers and thinkers. We are seeing fewer and fewer students who have this ability.
ARIAD PHARMACEUTICALS
What kinds of educational experiences do you want the Ph.D. chemists that you hire to have had? Roth: We are looking for people who
across multiple disciplines of chemistry, including medicinal/synthetic, analytical, and computational. In general, we seek individuals who have taken on challenging research projects and solved complex problems with scientific courage and creativity. We try to identify candidates who are not only well grounded in their core disciplines, but also demonstrate a keen interest in working at multiple scientific interfaces. In our experience, the more successful chemists often learn and master
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to patent law and protection of intellectual property in the pharma industry would be useful to help students prepare for the business and value-creation context of their work. Is it critical for students to have taken course work in medicinal chemistry to get a job in your company? Hill: No. It is the underlying science
behind medicinal chemistry that is most important to us. We want to see that candidates, almost all of whom have Ph.D.s, have a real understanding of the fundamentals of chemistry and biochemistry, such as enzyme kinetics and the way enzymes function; that knowledge is much more powerful than any exposure to medicinal chemistry that a student would get through a course. Shakespeare: No. Medicinal chemistry is something we can handle through on-thejob training. The most important thing is for students to find a good natural product target that is challenging to synthesize and dig in. Fundamentally, there is no substitute for carrying out a multistep synthesis that exposes students to a variety of different reactions, chemistries, and roadblocks. From our perspective, that is still A-number-one. Palkowitz: No. Our belief is that the best training for a medicinal chemistry position comes through an accomplished and diverse background in synthetic organic chemistry. The medicinal chemistry naturally builds on this foundation through cumulative experiences in drug discovery and cannot be effectively taught in a classroom setting. Does the pharma industry want universities to train chemists in computational chemistry (for example, for molecular modeling) for drug design? Hill: Although we might want those we
recruit for computational chemistry roles to have these skills, we don’t see a need for molecular modeling expertise in those we hire into medicinal chemistry positions. For the latter group, we would provide that training on the job. Roth: It would be good if students took some sort of course that exposed them to computational chemistry and structurebased drug design. We want and need people who are computer savvy, because we make intensive use of numerous computational tools. At the undergraduate level, we don’t expect new hires to be trained in these computational techniques, but we want them to be familiar with them. We need to ensure that those
“Interdisciplinary collaboration is becoming increasingly important.” we hire are not at all afraid of technology. Palkowitz: This is an important question, because predictive sciences are becoming such an important part of our work in drug design and optimization. Although the best way to learn and apply these techniques is through direct job experiences where they can be coupled to experimental validation, chemists should still consider taking introductory courses in the theory and methods for computational-based experimentation, if possible. If these courses don’t exist, I would suggest that universities might consider offering them. Do universities need to train chemists in molecular biology techniques? Hill: That kind of training does not ben-
efit most chemists who are applying to join Merck. Shakespeare: Our protein biochemistry experts come from the biological side, so I don’t think that chemists need to have training in molecular biology techniques to work at a company such as Ariad. Is it critical for universities to develop or bolster programs that foster interdisciplinary collaboration? Palkowitz: Yes. Interdisciplinary col-
laboration is becoming increasingly important given the nature of the complex scientific problems we are trying to solve and the need to bring together diverse scientific talent and capabilities from multiple sources. Any university programs that can provide initial interdisciplinary experiences to students will help make their transition to industry more fluid. Kress: Yes. Programs that allow for cross-disciplinary collaboration are important because university students are encouraged to pursue independent research and are frequently not connected to other researchers. However, within pharma, scientists have to be effective collaborators and have to feel comfortable bringing their scientific depth and problem-solving skills to cross-disciplinary teams. I believe that industry, governmental authorities, and academic institutions need to continue to sponsor cooperative programs that cut across one another’s boundaries. One example of this kind of effort is the National Science Foundation’s Grant OpportuniCEN.ACS.ORG
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ties for Academic Liaison with Industry program, which provides project funds or fellowships and traineeships to support university-industry partnerships. How important is it for universities to help their students develop communication skills? Shakespeare: Communication skills,
presentation skills—these are soft skills that are important for success in our field, and we don’t pay enough attention to them as we train chemists. Frequently, we run into candidates who have an obvious inability to effectively communicate. They are unable to defend a certain research topic or explain the rationale behind a target molecule, for example. As a result, their ability to succeed in the cross-functional world of drug discovery is compromised. Roth: During the interview process, the ability for a candidate to interact oneon-one is critical. We ask candidates to go to the blackboard and field questions or solve problems that we propose to them, so their ability to think on their feet and communicate their research work is absolutely essential to getting hired. The scientists we bring in have to have strong communication skills because everything we do here is team based. The Ph.D. chemists that we hire lead teams that might include 10 or more chemists, and because they have to be able to help those people in problem-solving, exceptional interpersonal skills are really important. How might universities help students build stronger communication skills? Roth: At the Ph.D. level, students often
develop solid communication skills through their participation in group meetings in which they are asked probing questions and are required to defend their work. However, bachelor’s and master’s students don’t often have this kind of opportunity. It would be beneficial if these students were required to do a research project and be involved in presenting their work. As part of that exercise, they should participate in group discussions that require them to problem-solve in a way that is unrehearsed. Those skills and abilities are things we look for in new recruits. Kozarich: I wish that more schools would offer a course on scientific presentation. It should be designed to help chemists
EMPLOYMENT OUTLOOK
communicate to other members of their teams as well as to people who may not be as knowledgeable or skilled in their area of expertise. Learning how to give an “elevator pitch,” a three-minute summary of your research, is also important. You never know when you may have a brief opportunity to sell an idea. Palkowitz: In helping students build communication skills, it’s important to recognize that no two individuals are alike and diverse communication styles can be equally effective, if properly developed and channeled. Any type of class setting— whether it involves writing, speech, debate, or a seminar—that can help individuals uncover their unique voice and effective communication styles should be encouraged. What other skills or experiences would you like universities to introduce to chemistry students to prepare them for working with you? Kozarich: It would be great if universi-
ties could somehow train students in the concept of situational awareness. When scientists come into the pharma R&D field,
many don’t seem to understand that what they do in their job is a function of the environment that they are in, the work being done by their colleagues, and the broader aspects of the problems that they are trying to solve. The students that seem to best understand situational awareness are those playing sports in college. Football players or basketball players are dealing with real situations, in real time, and competing with other teams. Unfortunately, many chemistry students don’t have the same opportunity to grasp this critical concept. Shakespeare: Universities should help students build relationships with those who work in the drug discovery industry. One way to do this is to bring in industrial scientists to serve as adjunct professors. Through these interactions, students can better identify the skills they need for future success and understand how their lab work or course work may be applicable to what they might be doing in the future as chemists. These relationships and interactions will help students find the right career path and, ultimately, influence the quality of the talent that ends up on our doorstep.
INCREASINGLY, UNIVERSITIES are
tuning in to the needs of industry in an effort to help their students compete for the few jobs available in today’s market, says Propel Careers’ Celano. In support of one such effort, she has been working closely with Boston University to launch a monthly seminar series that helps chemistry students develop communication, teamwork, and project management skills. “More universities are offering career panels or engaging their alumni network to allow students to bridge that gap between academics and industry,” Celano says. “Although these programs may seem to be extremely simple and intuitive, they represent a shift. Universities have not always been so open to having people come in from companies like Pfizer and talk about what they do.” Lee of the Murdock Charitable Trust concurs. “Parents and students are becoming increasingly interested in investing in a good education that gives the graduates an edge in getting a job and having a good start,” he says. Accordingly, universities are finding ways to help them do that. ◾
2014 Roundtable 2nd Edition Seventeen experts from academia, industry, and government laboratories share their thoughts on a variety of matters of importance to the readership of Organometallics.
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