Xenobiotics and Food-Producing Animals - American Chemical Society

Chapter 5 Semduramicin in the

Chicken

Downloaded by UNIV OF CALIFORNIA SANTA BARBARA on March 14, 2018 | https://pubs.acs.org Publication Date: August 24, 1992 | doi: 10.1021/bk-1992-0503.ch005

Tissue Residue Depletion Studies 1

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M . J. Lynch , G. M . Frame , J. F. Ericson , E. F. Illyes , and M . A. Nowakowski 1

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Drug Metabolism Department, Central Research Division, Pfizer Inc., Groton, CT 06339 Animal Health Product Development, Central Research Division, Pfizer Inc., Terre Haute, IN 47808 2

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When biosynthetically prepared C-semduramicin sodium, a new anticoccidial ionophore, was fed at 25 ppm in feed to broilers for 7 days, the tissue containing the highest total residues at all withdrawal times was liver. These residues were comprised mainly of unchanged semduramicin sodium (~45%) and an array of more polar, low-level (