Article Cite This: J. Org. Chem. 2018, 83, 69−74
pubs.acs.org/joc
Ytterbium-Catalyzed Hydroboration of Aldehydes and Ketones Weifan Wang,† Xingchao Shen,† Fengyi Zhao,† Huan Jiang,† Weiwei Yao,‡ Sumod A. Pullarkat,§ Li Xu,† and Mengtao Ma*,† †
College of Science, Nanjing Forestry University, Nanjing 210037, People’s Republic of China College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, People’s Republic of China § Division of Chemistry & Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore ‡
S Supporting Information *
ABSTRACT: The well-defined heavy rare-earth ytterbium iodide complex 1 (L2YbI) has been successfully employed as an efficient catalyst for the hydroboration of a wide range of aldehydes and ketones with pinacolborane (HBpin) at room temperature. The protocol requires low catalyst loadings (0.1− 0.5 mol %) and proceeds rapidly (>99% conversion in
