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Exploring QSAR This new two-volume set provides a thorough introduction to quantitative structure-activity relationships (QSAR). In Volume 1: Fundamentals and Applications in Chemistry and Biology the authors show how structureactivity relationships should be considered as a whole in quantitative terms, starting with physical organic chemistry and including all types of biochemical and biological processes. They give a unified view with extensive cross-referencing and show the interrelatedness of SAR from the ionization of acetic acid to the action of hallucinogens in humans. Throughout the book, QSAR in biological processes are related to those in physical organic chemistry. Volume 2: Hydrophobic, Electronic, and Steric Constants contains comprehen sive tables of physicochemical parameters (substituent constants and octanol-water log Ρ values) that are necessary for quantitative structureactivity relationships and qualitative SAR. These values were collected over 25 years by two of the most re nowned researchers in the field. Volume 1 by Corwin Hansch and Albert Leo Volume 2 by Albert Leo, Corwin Hansch, and David Hoekman ACS Professional Reference Book 880 pages (1995) Clothbound ISBN 0-8412-2993-7 $99.95 ORDER F R O M American Chemical Society Distribution Office Dept. 74 1155 Sixteenth Street, NW Washington, DC 20036 Or CALL TOLL FREE 1 800-227-5558 (in Washington, DC 872-4363) and use your credit card! FAX: 202-872-6067. ACS Publications Catalog now available on internet: gopher acsinfo.acs.org
Farrier focused on the federal and private mechanisms to induce pri vate landowners to conserve biodi versity. Nearly one-fourth of major ecosystems are inadequately mangaged by the government, he claims. To satisfactorily address biodiversity, command-and-control initiatives and voluntary landowner agree ments must be integrated and should include establishment of management and stewardship fees. (Harvard Environmental Law Review 1995, 19(2), 303-408)
RISK Potency estimates California has prescribed an expe dited process for estimating cancer potency that relies on one database of published studies and simplified analyses. S. M. Hoover and co-work ers derived potency estimates—es sential for assessing cancer risk—for 214 compounds using this method. Conventional potency estimates ex ist for 70 compounds. Of the derived estimates, 80% are within a factor of 5 of conventional estimates and 90% are within a factor of 10. This is comparable to the reproducibility of cancer potency determinations. (Risk Anal. 1995, 15(2), 267-80)
Ecological and human risk Ecological and human health risks must be considered equally when evaluating hazardous waste sites, but little guidance exists to define signif icant ecological risk. G. W. Suter and co-workers developed a framework to balance human and ecological risks from contamination and from remediation of it. Human and eco logical risks can be divided into three levels of concern. Unaccept able ecological risk involves threat ened species; acceptable ecological risk is defined by
