5 Zinc Absorption in Humans Effects of Age, Sex, and Food
Downloaded by CORNELL UNIV on September 7, 2016 | http://pubs.acs.org Publication Date: January 20, 1983 | doi: 10.1021/bk-1983-0210.ch005
R. L. AAMODT and W. F. RUMBLE National Institutes of Health, Bethesda, MD 20205 ROBERT I. HENKIN Georgetown University Medical Center, Center for Molecular Nutrition and Sensory Disorders, Washington, DC 20007 We have studied human Zn-69m and Zn-65 metabolism using a detailed kinetic model and the SAAM27 computer program. Absorption of Zn-65 by 75 fasting normal volunteers was 65±11% (mean± 1SD), range 40-86%). Absorption related to age (by decade) decreased linearly A=69.5-0.123Y (A=absorption, Y=age in years), correlation coefficient(r)=-0.934. Although mean absorption by women was higher (67± 2%, mean±1SEM) than that of men (63±2%) this difference was not s t a t i s t i c a l l y significant (ANOVA or t-test for comparison of means). Absorption related to age (by decade) was significantly less (p
