A 2-Iminohydantoin from the Oxidation of Guanine Volume 19

Additions and Corrections. A 2-Iminohydantoin from the Oxidation of Guanine [Volume. 19, Number 4, April 2006, pp 506r510] WENJIEYE, R. SANGAIAH,...
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Chem. Res. Toxicol. 2006, 19, 887

Additions and Corrections A 2-Iminohydantoin from the Oxidation of Guanine [Volume 19, Number 4, April 2006, pp 506-510] WENJIEYE, R. SANGAIAH, DIANA E. DEGEN, AVRAM GOLD,* K. JAYARAJ, KARL M. KOSHLAP, GUNNAR BOYSEN, JASON WILLIAMS, KENNETH B. TOMER, AND LOUISE M. BALL

The 13C-labeled starting material for the synthesis of [4-13C]Gua was, in fact, K13CN and not [2-13C]bromoacetic acid. The [2-13C]bromoacetic acid had been used for synthesis of [5-13C]Gua for another application. Scheme 1 and the yield of [4-13C]Gua remain unchanged. The synthesis of the Gua isotopomers (page 507) should read as follows: Synthesis of [4-13C]- and [7-15N]Gua. Synthesis of [4-13C]Gua and [7-15N]Gua were based on Scheme 1 (22), using the appropriately labeled synthons. For [4-13C]Gua, Scheme 1 was followed in its entirety starting with K13CN to give the 13Clabeled product in 21% overall yield. TX060086V 10.1021/tx060086v Published on Web 05/11/2006

10.1021/tx060086v CCC: $33.50 © 2006 American Chemical Society Published on Web 05/11/2006

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