Vol. 69
NOTES
2914
TABLE I
AMIDES AND -HETEROCYCLIC COMPOUNDS Amine used
FROM PHENYL
SALICYLATE AND
FROM PHENYL-l-HYDROXYNAPHTHALENE-2-
CARBOXYLATE Yield,
NitrogenFound
7 %
%
%.$I
Formula
Calcd.
1
With Phenyl Salicylate Piperidine Cyclohexylamine Benzylamine n-Butylarninel1 Laurylamine Diethylamine Ethylenediamine Chloroaniline Aminobiphenyl o-Aminophenol P-Aminophenoli2 m-Aminophenol 5-Aminoindazole 6-Aminoindazole rn-Phenylenediamine12 $5-Aminobenzotriazole 1.2,3,4-Tetrahydroquinoline
142-143 85-86 135-136 0
71-72 b
183-1x4 155 110 125 176 184 2: 9 234-235 199-200 245 138-139
69 79 77 81 75 68 69
83 85 22.4 57 58 37 31 49 42 34
CizHisNOi CiaHirNO2 CI&II$NO~
6.8 6.4 6.2
6.9 6.4 6.2
CisHaiNOa CiiHibNOn C,eHlsNtO~ CirHiiClNO CioHiiNOi CISHIINO~
4.6 7.3 9.4 15.3'
4.6 7.2 9.5 15.0'
CiaHiiNOz Ci4HiiN:O) C14HiiNa02
6. L l 16.62 16.62
6.10 16.57 16.56
Ci~HiaN4Oa CiaHisNOz
22.03 5.5
21.74 5 6
d
d
6. 63e
6.63"
With Phenyl- 1-hydroxynaphthalene-2-carboxylate I 63 CisHnNOa 5.77 5.8 0 0 o-Phenylenediamine > 265 78 CI?HI?NZO h h o-Aminophenol 188 89 C17fI(iX02 B. p. 153-156' (3 mm.). B. p. 146-148' (4 mm.). Chlorine. Calcd.: C, 78.80; H, 5.18. Found: C, B. p. 130-133' (1 mm.). Calcd.: C, 78.40; 78.8; H.5.1. 6 Calcd.: C,73.8; H,4.3. Found: C,74.24; H,4.53. H, 4.6. Found: C, 78.6; H, 4.4. Calcd.: C, 78.0; H, 4.22. Found: C, 77.9; H, 4.3. Diethylamine
f
acetanilideg or milinelo, from methyl salicylate and an aliphatic amine.11,12 (9) German Patent 289,027 [ F r d l . , 12. 184 (1014-10161]. (10) Schoyff, Ber., 26, 2740 (1892). (11) Hurd Fancher and Bonner, THISJOURNAL, 68,2745 (1946). (12) Fargher, Galloway and Probert. J. Textile Insl., 21. 245T (1930) [C.A , , 24, 6026 (1930)j.
COMMUNICATION No. 1154 KODAKRESEARCH LABORATORIES ROCHESTER 4, XEW YORK RECEIVED J U L ~10,1947
A New Process for the Preparation of Thioglycolylamides BY JAMES A. \'ASALLAN
I t is known that thioglycolylamides w a y be obtained by alkaline hydrolysis of carbamyl thioglycolylanilides' but the yields are low (15%) and several steps are required to obtain the product. Also acetothioglycolylamides, which are obtained from the acid chloride and an amine, may be saponified to the required thioglycolylarnides but the intermediate acid chloride2 is difficult. to obtain, and again the process consists of several steps. I t has now been found that thioglycolylamides may be made in excellent yield and in a high state of purity without protecting the thiol group. The process consists of mixing an amine and thiogly(1) Beckwts and Frerichs. J . 9rakf. Chcm.. 121 66, 174 (1902). (2) Benary, B n . , 16, 2106 (1018).
Q
colic acid in molecular proportions with benzene as a solvent and utilizing a Clarke-Rahrs ester column3to remove the water as it is formed. The reactants are a t all times in an atmosphere of benzene during the course of the reaction, which minimized the formation of disulfide. The crude product, therefore, usually possesses a higher degree of purity than that obtained by other processes. The process is illustrated bv the preparation of thioglycolylanilide. Thioglycolylani1ide.-Thioglycolic acid (46 g.) and aniline (45 9.) are mixed in 250 nil. of benzene. This solution is refluxed, using an ester column, until approximately 9 ml. of water has separated (about nine hours). The benzene solution is then treated with an equal volume of petroleum ether and chilled. The product (70 g., 85%) separates as a mass of white crystals; m. p . 103105'. A recrystallization from dilute alcoho! raises the melting point to 110". (3) Eastman Kndak Ciimpany. "Syn. Or& Chem ," 9, No 3 May (1936)
COMMUNICATION No. 1156
KODAKRESEARCH LABORATORIES ROCHESTER 4. NEWYORK RECEIVED JULY 26, 1947
Resonance and Hydrogen Bond Effects on the Basic Strengths of Certain Arylalkyl Azomethines BY CHARLES D. WAGNERAND EDWARD I).PETERS
When aliphatic primary amines are treated with most of the common aromatic aldehydes, azo-
