Aliphatic Diazo Compounds. VIII. The Reaction of Diazo Ketones with

Publication Date: October 1963. ACS Legacy Archive. Note: In lieu of an abstract, this is the article's first page. Click to increase image size Free ...
0 downloads 0 Views 1MB Size
Download PDF
DIAZOKETONESWITH BASES

Oct. 5 , 1963

ether and subsequent sublimation in oacuo gave L I I I as a white solid, m.p.213-214'; X~~~'a2.80,2.90(shoulder), 5 . 8 0 ~ &':,,380. ;

[CONTRIBUTION FROM THE

DEPARTMENT OF

2967

A n d . Calcd. for CiaHlsOa: C, 63.14; C, 62.47; H, 6.71.

CHEMISTRY,

HARVARD UNIVERSITY,

CAMBRIDGE

38,

H, 6.81.

MASS.]

Aliphatic Diazo Compounds. VIII. The Reaction of Diazo Ketones with Bases. BY

PETER

YATES3 AND DONALD G.

Found:

I11s2

FARNUM4

RECEIVED FEBRUARY 23, 1963 The reaction of a-diazoacetophenone with sodium methoxide in concentrated solutions in methanol has been found t o give 3-benzoyl-4-phenylpyrazole ( I ) , 3-benzoyl-5-hydroxy-4-phenylpyrazole(11), 3-benzoyl-4-hydroxy-5-phenylpyrazole (111), 5-benzoyltetrazole ( X X V ) , a compound, C17HllN50, considered to be most prob-1,2,4-triazine ( X L I I I ) , benzoic acid, and methyl benzoate. The ably 3-benzoyl-5-phenyl-l,2,3-triazolo[3,4-b] structures of compounds I, 11,111, and XXV have been established by comparisons of these products with authentic samples prepared by rational, independent syntheses. The assignment of structure X L I I I to the product C17HllKSO has been made largely on the basis of the base-induced cleavage of this compound to 4-benzamido5-benzoy1-1,2,3-triazole (XXXV), whose structure has been established by independent synthesis.

It has previously been found1 that the reaction of dilute solutions of a-diazoacetophenone in hydroxylic solvents with strongly basic reagents is complex and gives rise to a mixture of products which includes benzoic acid, acetophenone, 3-benzoyl-4-phenylpyrazole (I), and 3-benzoyl-5-hydroxy-4-phenylpyrazole (11) (vide infra). In all cases a reaction time of several hours a t 75-90' was required to ensure total, irreversible consumption of the diazo ketone.

3-T&c0c6H5

HO

C6H5qcocd&

HI

The compound C16HlzN~Oz was shown to be identical with the product of this composition obtained previouslyl by the reaction of dilute solutions of diazoacetophenone with bases. The earlier work had shown that the compound is resistant to boiling aqueous ethanolic potassium hydroxide and to boiling 1: 1 hydrochloric-acetic acid, dissolves readily in dilute aqueous sodium hydroxide to give a yellow solution which reduces potassium permanganate to manganate, and gives a red coloration with a solution of ferric chloride in chloroform-pyridine. On the basis of these properties and its origin i t was considered to be one of the hydroxypyrazoles I1 or 111. In the present work a choice between these alternatives was made possible on three counts. I t was observed that the substance is soluble in aqueous potassium carbonate,Bthat it fails to give a coloration with ethanolic ferric chloride, and that on oxidation with perbenzoic acid it affords an amorphous solid, which upon crystallization from solvent mixtures containing ether yields a colorless, crystalline substance, CS~HZ~N ~ O ~ . A significant difference between C4HIoO. structure I1 and I11 is that the latter contains a chelated hydroxyl group, while the former contains a free hydroxyl group. Both the relatively strong acidity of the compound Cl6Hl2N2o2 and its failure to give a color test with ethanolic ferric chloride are in accord with the expected properties of a nonchelnted aromatic hydroxyl group as is present in structure II.' The significance of these observations was markedly enhanced by the availability of an isomeric compound obtained from the weak acid fraction which exhibited the properties expected for the chelated hydroxyl compound I11 (bide infra). Finally, the formation of the compound CszHzzN404 is readily interpreted as an oxidative coupling reaction of a type often observed with S-pyrazolonesj8leading to compound IV. The infrared spectrum of the oxidation product (bands a t 3.13, 3.25, 5.68, and 6.04 p ) is in accord with this assignment; the band a t 6.04 p is assigned to the benzoyl groups and that a t 5.68 p to the five-membered lactam carbonyl groups which have been modified by the inclusion of the amide nitrogen atom in a conjugated system of type An analogous shift to shorter C6H&=C-N=NH--.

c6H5GCoc6&

C6H5

I11 H HO

H I1

In a further investigation of the reaction of a-diazoacetophenone with bases, we have found that the addition of concentrated methanolic sodium methoxide to a concentrated solution of a-diazoacetophenone in methanol leads to a violent, exothermic reaction. We describe here the results of an investigation of the structures of the products formed under these conditions ; we shall postpone discussion of the mechanistic implications of our results until the completion of further experiments currently in progress.5 A 7 M solution of sodium methoxide in methanol was added dropwise to a 5 ' 14solution of diazoacetophenone in methanol; approximately equimolar amounts of base and diazo ketone were used. The reaction was moderated by efficient external cooling, which was necessary to prevent vigorous gas evolution with excessive foaming. After completion of the reaction the mixture was poured into dilute aqueous sodium bicarbonate and the crude product was separated into three fractions : acid (bicarbonate-soluble), weak acid (bicarbonate-insoluble, hydroxide-soluble) , and neutral. Acid Fraction.-From the bicarbonate-soluble fraction were isolated a pale yellow, crystalline, waterinsoluble compound, C16HI2N202,m.p. 248.5-2SOo, and a coIorIess, crystalline, water-soluble compound, CsH6N40, m.p. 139.5-140°. In addition, infrared spectral evidence indicated the presence of benzoic acid. (1) F o r P a r t I of this sub-series see P. Yates a n d B. L. Sbapiro, J . A m . Chem. SOC., 81, 212 (1959). (2) A preliminary report on p a r t of this work has appeared previously: P. Yates and D. G. F a r n u m , Telrahedvon Letteus, No. 17, 22 (1960). (3) D e p a r t m e n t of Chemistry, University of Toronto, Toronto, C a n a d a ; Alfred P. Sloan Foundation Fellow, 1957-1960. (4) X . I . H . Fellow, 1957-1959, ( 5 ) W e have already made some proposals in regard t o t h e reaction routes.2

1

-9

00 (6) Although t h e product was isolated f r o m a bicarbonate-soluble fraction of t h e crude reaction product, in t h e pure s t a t e i t is n o t soluble in aqueous sodium hicarbonate. (7) H . Henecka, "Chemie der p-Dicarbonylverbindungen," Springer Verlag, Berlin, 1950, p. 111. (8) T. L. Jacobs in "Heterocyclic Compounds," R. C . Elderfield, E d . , Vol. V, John Wiley a n d Sons, Inc., New York, N. Y., 1957, pp. 124,125, 135. (9) T h e spectrum of t h e crystalline product has a strong band a t 9 . 1 p . absent in t h e spectrum of t h e amorphous material, corroborating t h e presence of ether of crystallization in t h e crystalline product.

PETERYATESAND DONALD G. FARNUM

2968

wave length of the carbonyl-stretching band in the case of a noncyclic amide is observed for benzil N-acetylhydrazone (V) (bands a t 5.87 and 5.98 p ) and l-phenyl1,2-propanedione 2-N-acetylhydrazone (VI)l o (bands a t 5.80and 5.91 p ) . H

N,"@ CsH5COC=NNHCOCHa

I

R

H V, R=CsHs IV VI, R = C H 3 The assignment of structure I1 was confirmed by an independent synthesis of 11. The known methyl /3-benzoyl-/3-bromo-a-phenylpropionate (VII) (higher-melting epimer) was chosen as starting material in the expectation that it would give with hydrazine the displacement product VI11 ; although the possibility of dehydrobromination of the /3-bromo ester was recognized, i t was considered that the reactivity of the bromine in displacement reactions would be sufficiently enhanced by the adjacent carbonyl group to permit a competing displacement reaction. l1 Subsequent cyclization of the intermediate VI11 would lead to IX, a dihydro derivative of 11, which, since i t is both a pyrazoline and an 01amino ketone, should be subject to facile oxidation to II.12 When VI1 was treated with hydrazine and potassium carbonate and air was passed thxough the reaction solution, the carbonate-soluble fraction afforded I1 (yield 13YG),identical with the product obtained from diazoacetophenone. :NHzXHz COzCH3

(

C6H5C0

)IC& VI1

Br 2

+

H N 2 0 2 c H 3 CsHsCO C6H5 VI11

4

Vol. 85

tive decarboxylation with bromine in aqueous sodium bicarbonate gave, as anticipated, 3,5-diphenylpyrazole (XI), identified by comparison with an authentic sample.13 The formation of X may readily be seen to be the result of the expected competing dehydrobromination of VII. Addition of hydrazine to the a,p-unsaturated ketone system of the resultant product XI1 in the expected fashion,l4 followed by cyclization, would lead to the methyl ester XIII, which could undergo ready hydrolysis in the hot, basic reaction medium to give X. The third crystalline product, which was the major product of the reaction of VI1 with hydrazine, was obtained from the carbonate-insoluble, hydroxide-soluble fraction of the reaction mixture and was identified as the known 3,5-diphenyl-G-pyridazinone (XIV) by comparison with an authentic sarnple.ls Its formation by condensation of hydrazine with either VI1 or XI1 is unexceptional. 0

0

4

C6H5 XIV

XI1 The isolation of the pyridazinone derivative XIV led us to consider a conceivable alternative structure for the compound assigned structure 11. It may be seen that the structure 3,5-diphenyl-4-hydroxy-6-pyridazinone (XV) possesses a number of features which qualify it for consideration. Base-solubility and a positive ferric chloride test in chloroform-pyridine are clearly to be expected for XV, and its infrared spectrum might well be compatible with that observed. Furthermore, the structure XV bears a fundamental resemblance to the bromo ester VI1 used in the independent synthesis, and a less straightforward, but amusing, resemblance to diazoacetophenone. The only piece of evidence adduced thus far which appears to be incompatible with this structure is the infrared spectrum of the oxidation product, C32HZ2N4O4.This would have to be assigned structure XVI on the basis of structure XV for its precursor. However, structure XVI provides no functional group which would be expected to give rise to the unusually short wave length carbonyl-stretching band observed a t 5.68 p . It was possible, fortunately, to obtain more decisive evidence on which to base the exclusion of structure XV as a result of an ancillary synthetic investigation in connection with structure 11.

- c6H5)p( c6H5Fc0c6H5 COC~HS

io1

O

"NH H

HO

IX

h"'

H

I1

Two other crystalline products were isolated from the mixture resulting from the ieaction of VI1 with hydrazine. The bicarbonate-soluble fraction afforded, upon crystallization from chloroform, a substance, (Cl6H14NZOl)z*CHC13,with infrared bands a t 3.0, 4.0, and 5.90 p which is considered to be a chloroform solvate of 33diphenyl-2-pyrazoline-5-carboxylicacid (X). Oxida-

XI

XI1

VI1 HzN\

XI11 (10) H . A. Morrison, Ph.D. Thesis, Harvard University, 1961. (11) P. D . B a r t l e t t and E. K. Trachtenberg, J . A m . Chem. Soc., 80, 5808 ( 1958). (12) P. L. Julian, E. W. Meyer, A . Magnani, and W. Cole, ibid., 67, 1203 (1943); cf , also, P. Yates, ibid., 74, 5376 (1952).

XVI

The reaction of hydrazine with the known p-lactone XVII (lower-melting epimer) l6 in benzene-methanol proceeded rapidly a t room temperature to give a nearly quantitative yield of a compound, C16H16N203, considered to be the y-lactam XVIII on the basis of the following evidence. Its solid-state infrared spectrum includes complex absorption in the 3 p region (OH and (13) L. Knorr and P. Duden, B e y . , '26, 111 (1893). (14) S . H . Crornwell, P. L . Creger, and K . E . Cook, J . A m . Chem. S O L . . 78, 4412 (1956). (15) G. K . AlmstrBm, A n n . , 400, 131 (1913). (16) E. P. Kohler and R. H. Kimball, J . A m . Chem Soc., 66, 729 (1934).

DIAZOKETONES W I T H BASES

Oct. 5, 1963

NH stretch) and bands a t 5.82 p (7-lactam C=O stretch), 6.1 p 2"( deformation) and 9.05 p (OH deformation). The presence of a primary amine function was demonstrated by reaction with nitrous acid to give gas evolution, and reaction with benzaldehyde in the presence of sodium acetate to give a monobenzylidene derivative, C23H20N2O3 (infrared bands a t 2.85, 3.0, 5.88, and 9.05 p ; no band a t 6.1 p). Further confirmation of the presence of the y-lactam group of XVIII was forthcoming from the infrared spectrum of the hydrochloride of the p-lactone-hydrazine product. This possesses, in addition to bands ascribable to OH and NH3@groups, a sharp band a t 5.75 1.1. The shift in the carbonyl absorption from 5.82 to 5.75 p is readily interpreted in terms of the transformation XVIII+ X I X ; thus the carbonyl-stretching band of 3-phenyl-5pyrazolidinone (XX)" a t 5.86 p shifts to 5.71 p on formation of the hydrochloride XXI. The absence of a conjugated phenyl group in the p-lactone-hydrazine product was demonstrated by the absence of strong ab-

2969

dazinone, on the basis of the close similarity of its spectra to those of 4,5-dihydro-3,5-diphenyl-6-pyridazinone (XXIII)18(Table I). These data are only compatible with the assignment of structure XVIII to the /3-lactone-hydrazine product, which must arise via the hydrazide XXIV. The isolation of the hydroxydihydropyridazinone X X I I now provided a ready source of the hydroxypyridazinone XV, the possible alternative formulation for the product from diazoacetophenone. Oxidation of XXII with bromine in dioxane yielded a base-soluble product, C16HlzNa02, whose solid-state infrared spectrum (broad absorption in the 3-4 p region and a sharp band a t 6.15 p ) , although compatible with its formulation as XV, is different from that of the isomeric product from diazoacetophenone, which can now be formulated as I1 without ambiguity. I t is interesting to note that the infrared spectrum of XV lacks the strong band in the region 10.7-11.2 p , present in that of 11, which has been found to be characteristic of nitrogen heterocycles bearing a C-benzoyl group.l 9 TABLE I SPECTRA O F 4,5-DIHYDRO-3,5-DIPHENYL-6-PYRIDAZINONES , ": :A Nujol --Amax,

XXII ( R = OH)

R cGH*

xx

XIX

" 6H5

XXIII ( R = H)

-M

mr (1%

4

2.95, 3.10, 3.20 288 (4.20) 5.97, 7.98, 9.25

3.08, 3.20 288 (4.21) 5.98, 8.00

XXI

The other product, CsH6N40, isolated from the acid sorption above 220 mp in the ultraviolet spectrum of this fraction from the reaction of diazoacetophenone and substance. On treatment with boiling ethanolic hysodium methoxide, is soluble in aqueous sodium bicardrochloric acid it was converted to 3,5-diphenyl-6-pyribonate and forms a non-acidic, monomethyl derivative, dazinone (XIV).I5 This transformation could also be C9HgN40, with diazomethane. The infrared spectrum carried out in two stages : when the 0-lactone-hydrazine (CHzC12) of the compound CsHsNIO includes bands a t product was heated in boiling nitromethane i t was con2.95, 6.00, and 10.85 p , while that of its methyl derivaverted to a compound, CleHlaNrOz,which was converted tive has bands a t 5.99 and 10.88 p , but no band in the to XIV on treatment with ethanolic hydrochloric acid. N-H stretching region. On the basis of these data and The intermediate compound is assigned structure X X I I , i . e . , 4,5-dihydro-4-hydroxy-3,5-diphenyl-6-pyri-its origin, the product CsH6N40 appeared most likely to have structure XXV or XXVI. C6H5 OH C6H5

1I"'

%

u C 6 H 5

I

- q:5 2"

"*

XVIII

XXIV

1.

HO+h I

c6H5

xv (17) I.. A . Carpino, J . Am. Chem. SOL.,80, 599 (1958)

xxv

XXVI

XXVII The tetrazole XXV, like other tetrazoles unsubstituted on nitrogen, was expected to be acidicz0 with this acidity enhanced by the inductive and resonance effects of the benzoyl group.z1 The solution infrared spectrum of the product also appeared to be compatible with structure XXV, as did the solid-state spectrum, which shows evidence of strong hydrogen bonding in the solid (NH bands a t 3.7 and 3.85 p ) . Although tetrazinones related to XXVI do not appear to have been described, it appeared likely that such a system could also account for the strong acidity and infrared spectrum of the product.z2 A preliminary choice was made between these alternatives on the basis of the failure of the prod(18) J . Druey and B . H. Ringier, Helu. Chim. A c t a , 34, 195 (1951) (19) D . G . Farnum and P. Yates, J . Org. Chem., 17, 2209 (1962). ( 2 0 ) F . R . Benson, Chem. R e s . . 41, 4 (1947). (21) Thus the K , of tetrazole is 1.28 X 10-6, while that of e t h y l Stetrazolecarboxylate20 is 4 X IO?. ( 2 2 ) Thus its infrared spectrum resembles that of 4-phenyl-1,2,5-triazin&one (XXVII),z' which is soluble in dilute aqueous sodium carbonate. ( 2 3 ) L. Wolff, A n n . , 326, 148 (1902).

PETERYATESAND DONALD G. FARNUM

2970

uct to give a positive ferric chloride test. Since pyridones, pyridazinones, and triazinones give positive tests,24it seemed unlikely that XXVI would fail to do so. The rational synthesis of XXV was therefore undertaken. 5-Benzyltetrazole (XXVIII) was prepared by the method of Finnegan, et a1.,25and was oxidized with chromium trioxide to 5-benzoyltetrazole (XXV).26 This product was found to be identical with the product CsHsN40obtained from diazoacetophenone. CBHjCH,CN

+

3_ CrO

C,H,CO

NH,%N,O

&,I

H

XXV Weak Acid Fraction.-From the hydroxide-soluble fraction was isolated a pale yellow, crystalline substance, C16H129202 The remainder of the fraction after being heated afforded a bright yellow crystalline substance, C1,HllN50, which did not dissolve in aqueous sodium hydroxide. Attempts to isolate the hydroxidesoluble precursor of the latter product were unsuccessful. The compound CI6Hl2Nz02was obtained in two different crystalline modifications. There are considerable differences in the solid-state infrared spectra of these two forms, but the spectra resemble each other in having complex absorption in the 3 p region, a sharp band a t ca. 6.15 p , and strong absorption near 11 ,u. The product dissolves in dilute aqueous sodium hydroxide to give a yellow solution which reduces potassium permanganate, but is only slightly soluble in dilute aqueous sodium carbonate. I t gives an intense bluegreen coloration with ethanolic ferric chloride. The relationship of these properties to those of the isomeric product I1 suggested strongly that this compound has the chelated structure 111, the alternative formulation earlier considered for the isomer. This assignment was supported, but not proved, by the observation that the same compound was obtained in moderate yield, together with other p r o d ~ c t s ,by ~ ’ the reaction of diazoacetophenone with the pre-formed anion of methyl phenylacetate in ether. The formation of 111 in this latter reaction was expected to occur by a route of the type depicted below.28 Conclusive corroboration of the structural assignment was obtained by the independent synthesis of 111 in good yield by the photolysis of 3-benzoyl-4-hydroxy-5-phenylpyrazole(XXIX) in aqueous acetone.29 ()e

C,H&CH-&N~’CHC6H5 kl

II

--t

?J T=N \ C6H5C=CH CHC6H, L3 ,../

Vol. 8.5

The compound C17HllN50has in its infrared spectrum bands a t 6.07, 6.50, and 11.00 p but no absorption characteristic of NH or OH stretching vibrations. I t exhibits a bright blue fluorescence under ultraviolet illumination either in the solid state or in solution in organic solvents. Solutions in sulfuric acid, from which it is recovered unchanged on dilution with water, are, however, nonfluorescent. On treatment with a boiling mixture of hydrochloric and acetic acids it gave benzoic acid and a colorless, blue-fluorescent oil with no N H or C=O stretching bands in its infrared spectrum. These data, together with the ultraviolet spectrum (Table 11) of the compound CliHI1N50,appeared to be most readily accommodated in terms of the tetraazapyrrocoline part-structure XXX. The fluorescence of pyrrocoline (XXXI) and its analogs is well known,”’,.”’ while the pyridinium cation systetn of the conjugate acid XXXII is n o n f l u ~ r e s c e n t . ~hlthough ~ close models for the ultraviolet spectra of systems of type X X X are not available, the spectra of the derivatives of X X X I given in Table I1 provide some basis for comparison. TABLE I1 ULTRAVIOLET SPECTRA O F COMPOUNDS RELATED TO P Y R R O C O L I N E

* Cornp o u n d

CI~HIIX~O

@JC, Q6Hs COCHJ

_-__

Xmnx, m r (log e)---Neutral medium Acid medium

(363(3.99) 283(4.36)

{

1;;;;;:y

305 ( 3 . 7 ) { 290(3.7) (240(4.1) 333 (3.88) 248(4.62) 365(3.99) { 264 ( 4 . 3 6 ) \ 233 ( 4 32)

/

12ef.

360(4.43) 252 ( 4 . 4 0 )

320(3.8) 250 ( 3 8 5 )

32

303 ( 4 . 1 8 ) 239(4.33)

31,34

35

The general characteristics of the spectra are similar, particularly in regard to the marked change observed in acid medium. The attachment of a benzoyl group to one of the heterorings was indicated by the band a t ll.0C p in the infrared spectrum of the compound.’Y Further, the facile formation of benzoic acid on acidcatalyzed hydrolysis suggested that the benzoyl group is attached to the five-membered ring, for ready hydrolytic loss of acyl substituents on the 2- or 4-position of the pyrrocoline system is well established.3 3

COzMe

xxx

XXIX (24) H . S . Mosher in “Heterocyclic Compounds,” R . C Elderfield, E d , Vol I , John Wiley and Sons, Inc., S e w York, N. Y., 19.50, p . 526 ( 2 . : ) W. G. Finnegan, R . A. Henry, and R . Lofquist, J . A m . C h e m Soc., 80, 3908 (1958). (26) Since the completion of this work, an alternative synthesis of X X V has been reported. B . E. Fisher, A . J Tomson, and J P. Horwitz, J . Ovg. C h e m , 24, 1650 (1959). (27) D . G . Farnum and P Yates, P Y O CChem . Sa.,2 2 4 (1960). (28) Cf the formation of diethyl 4-hydroxypyrazole-3.~-dicarboxylate from ethyl diazoacetate and the sodium derivative of diethyl malonate: A . Bertho and H . Xussel, A n n , 457, 278 (1927). ( 2 9 ) D. G . Farnum and P. Yates, J . A m . Chem. SOL.,84, 1399 (1962).

xxxr

XXXII

More detailed structural information was provided by a study of the cleavage of the compound CliH11XsO in alcoholic base. This was rapid and led to the formation of a colorless, base-soluble, crystalline compound, C16HleN402, which exhibits an intense yellow-green fluorescence in ultraviolet light. Its infrared spectrum includes bands a t 3.12 (complex), 5.97, 6.11, 6.30. and 10.70 w . It was recovered unchanged after treatment with sodium nitrite and concentrated hydrochloric acid in dioxane; the absence of a primary amine function was thus indicated. However, the presence of a masked (30) (31) (32) (33) (34) (36)

E T. Borrows and D. 0 . Holland, C h e m R e v . , 41, 62-1 (1948) J . D . Bower and G . R Ramage, J Chem. Soc., 1606 (195;) J . E . Saxton, i b i d . , 3239 (1951) Reference 30, p . 627. E. A . Chandross, private communication. Reference 30, p . 635.

DIAZOKETONES WITH BASES

Oct. 5, 1963

primary aromatic amine function was indicated by the fact that protracted warming with acidified +dimethylaminobenzaldehyde in ethanol resulted in the formation of a deep red Hydrolysis by prolonged boiling in a hydrochloric-acetic acid mixture or by brief boiling in alcoholic base resulted in extensive decomposition with the formation of benzoic acid as the only nonvolatile acidic product. The absence of an enolic, or potentially enolic, hydroxyl group was indicated by failure to give a color reaction with ferric chloride either in ethanol ox in chloroform-pyridine. These data suggested that the compound C16H12Nd& might contain a benzamido group attached to an aromatic system (cf. infrared bands a t 3.12, 5.97, and 6.30 p ) and that the benzoyl group attached to carbon, indicated to be present in its precursor, might remain ininfrared bands a t 6.11 and 10.70 p ) . %-e were tact (6. thus led to consider the part-structure XXXIII. The disubstituted aromatic residue, CzHN3, could then be either 1,2,3- or 1,2,4-triazole. The base solubility of the compound and an observed bathochromic shift of 22 mp in the position of its long wave length ultraviolet maximum in the basic solution further suggested that the triazole is unsubstituted on n i t r ~ g e n . ~Two ~.~~ alternative structures, XXXIV and XXXV, then emerged as possible formulation^.^^ Since the amount of the degradation product available was small, attention was turned to the independent synthesis of the compounds XXXZV and XXXV.

XXXIV

xxxv

H

I

CGH5

XXXVI Compound XXXIV was synthesized by the route C6H,CH2CO2H

M7. XXXVII C6H5C0- S

NHCOC,H,

XXXVIII XXXIX Although the condensation of phenylacetic acid with aminoguanidine nitrate in nitric acid40 resulted in extensive tar formation, condensation could be effected with aminoguanidine sulfate in sulfuric acid to give a moderate yield of the aminotriazole XXXVII. Benzoylation then gave a mixture of two isomeric rnonoben: (36) F. Feigl, "Spot Tests," Vol. 11, Elsevier Press, S e w York, N. Y . , 1954, p 203. (37) F. R . Benson and W. L. Savell, Chem Rev., 46, 6 (1950). (38) T h u s , t h e long wave length ultraviolet maximum of 3,5-diphenyl1,2,4-triazole a t 255 mp in neutral medium is shifted t o 276 mp in basic medium: M R.Atkinson, E . A. Parkes, and J . B. Polya, J . Chem. Soc., 4256 (1954). (39) If t h e retention of t h e C-benzoyl group is not assumed, phenylbenzamidotriazinones, e . & X X X V I , must also be considered. These can be excluded, however, because of t h e negative ferric chloride test. (40) This is a generally successful method f o r t h e preparation of %substituted 3-amino-1,2,4-triazoles. M . R . Atkinson, A. A . Komzak, E . A. Parkes, and J B. Polya, J . C h e m . S o c . , 4508 (1954).

297 1

zoyl derivatives. The lower-melting isomer (infrared bands a t 2.95, 3.10, 5.90, 6.08, and 6.45 p ) was converted quantitatively to the higher-melting isomer (infrared bands a t 3.2, 5.96, 6.35, and 6.45 p ) by being heated above its melting point. Comparison of their infrared spectra leads to the assignment of the nuclear benzoylated structure XXXVIII to the louer-melting isomer and the secondary amide structure X X X I X to the higher-melting isomer. Oxidation of the latter with chromic acid gave a quantitative yield of a colorless, crystalline, nonfluorescent substance, CI6H12N402,whose properties (infrared bands a t 2.95, 3.15, 5.90, 6.00, 6.23, and 10.82 p ) are in accord with its formulation as XXXIV. This substance is, however, different from the compound of the same composition formed by base cleavage of the compound C17HllN50. Compound XXXV was synthesized by the route

XXXV The condensation of nitriles with azides has been found to give 1,4-disubstituted 5-amino-1,2,3-triazoles,41 and this method was investigated for the preparation of the aminotriazole XL. Although condensation of hydrocinnamonitrile and benzyl azide could not be effected with sodium ethoxide in boiling ethanol, nor with potassium t-butoxide in boiling l-butyl alcohol or in tetrahydrofuran,42>43 the reaction could be effected by means of prolonged boiling with sodium amide in diisopropyl ether. There was thus obtained in moderate yield a substance, C16H16N4 (infrared bands a t 2.85, 2.95, and 6.08 p ) , assigned structure XL. Benzoylation of this afforded the crystalline amide XLI (infrared bands a t 2.95, 5.91, and 6.25 p ) , which upon oxidation with two equivalents of chromium trioxide gave a quantitative yield of 5-benzamido-4-benzoy1-l-benzyl-l,2,3-triazole (XLII). The structure assigned to this product is based on its elemental analysis, infrared spectrum (bands a t 3.12, 6.05, 6.12, and 10.82 p ) , stability to boiling ethanolic potassium hydroxide, 44 and reconversion to XLI on hydrogenolysis over acid-washed palladiumcharcoal. Cleavage of the N-benzyl function of XLII could not be effected by solvolysis, hydrogenolysis, treatment with boiling hydriodic acid, nor with sodium in liquid ammonia. Prolonged reaction with excess chromium trioxide in acetic acid-sulfuric acid, however, resulted in removal of the benzyl group, presumably via oxidation and hydrolytic cleavage, with the formation, albeit in low yield, of a colorless, crystalline, fluorescent substance, XXXV. This was shown to be identical with the product formed by cleavage of the compound C17HllN60with base. (41) Reference 37, p . 31. (42) E . Lieber, T. S Chao, and C . N R . Rao, J . O w . C h e m . , 11, 654 (1957). (43) T h e reaction in tetrahydrofuran gave a high yield of a crystalline substance which appears t o be t h e Thorpe self-condensation product of hydrocinnamonitrile ( 4 4 ) Had oxidation of t h e ?--benzyl function of X L I occurred. t h e product would have been a base-sensitive nuclear h--benzoylated triazole.

PETERYATES AND DONALD G. FARNUM

2972

Ramifications of the part structure X X X for the compound C17H11Nb0can now be considered on the basis of the formation of the triazole XXXV on hydrolysis with base. Two full structures, XLIII and XLVII, accommodate the facts and provide a basis for the postulation of reasonable interpretations of the course of the base cleavage reactions. In the case of XLIII the following scheme may be considered.

XLIII

XLIV

xxxv

-

J

H* CeHbCONH

CGHSCO

Hydration of XLIII to give XLIV followed by elimination of hydrogen cyanide could give the anion of XXXV. Such elimination finds analogy in the base-catalyzed hydrolysis of isonitrosoacetophenone (XLV) to benzoic acid and hydrogen cyanide.45 0

Vol. 85

N o rigorous choice can be made between structures XLIII and XLVII for the compound C17HllN50 on the basis of the data currently available. However, structure XLIII is favored since its formation is more readily accommodated in terms of the mechanistic scheme2 considered most likely to be operative in the reaction of diazoacetophenone with sodium methoxide. A further point of interest concerning this compound is the fact that although its solutions in 5070 aqueous sulfuric acid are colorless, solutions in concentrated sulfuric acid are yellow-orange. The latter show an intense maximum in the visible region a t 420 mp (log t 4.64)) and maxima in the ultraviolet region a t 362 mp (log t 4.28), 300 mp (log e 3.67), and 240 m p (log t 3.83). The compound is recovered unchanged on dilution of these solutions with ice-water. These observations can be interpreted in terms of XLIII as due to the formation of the monocation LT by protonation on nitrogen in 50% sulfuric acid and of the dication LII by further protonation on oxygen in concentrated sulfuric acid, the fulvenoid system of the latter accounting for the visible absorption maximum. 48

09

ll OH0 II r Ce,HsCCH=NOH + CsHsC-CH=N-OH IXLV

4

OH

C6HsC02H -I- H C X

+ OH8

An alternative path from XLIII to XXXV could involve proton abstraction, ring cleavage to XLVI, and hydrolysis Cab OHF

----t

XLIII H,O-

This route finds analogy in the base-catalyzed cleavage of isoxazoles to @-ketonitrile@

LI

LII

Neutral Fraction.-The only crystalline compound isolated from the neutral fraction was 3-benzoyl-3phenylpyrazole ( I ) , identified by comparison with an authentic This compound, traces of which were also isolated from the hydroxide-soluble fraction, had previously been found to be formed in the reaction of dilute solutions of diazoacetophenone with bases. l The remainder of the neutral fraction had the characteristic odor of methyl benzoate and its infrared spectrum exhibited all the bands present in the spectrum of methyl benzoate. The products detected in the mixture obtained from the reaction of concentrated solutions of cr-diazoacetophenone with methanolic sodium methoxide are summarized in Table 111. The yields of compounds which TABLE I11 PRODUCTS (AND YIELDS ISOLATED) FROM THE KEACTIOS O F a-DIAZOACETOPHENONE AND SODIUM METHOXIDE 1.U

In the case of XLVII. analogous routes to those considered for XLIII would lead to the triazole XLIX, e.g., v i n XLVIII. This triazole could rearrange to the trizole XXXV by a well-established type of route4' involving the intermediacy of the chain tautomer L.

C6Hi XLVII

CONCESTRATED SOLUTION

XLVIII

H 2 N 4 0 C 6 H 5

\\

XLIX

N

a

L (4.5) I*. Claisen and 0. Uanasse, B e y , 20, 2194 (1887) (46) R A . Barnes in r e f . 8 , p. 463. (47) E. Lieber C N R . R a o . and T . S. Chao, J . A m . C h e m . Soc , 79, 5962 (1957).

have been isolated are also given. It may be noted that much of the complex reaction mixture remains unaccounted for, in spite of the identification of seven products. (48) C+ , E D . Bergmann a n d Y Hirshberg, Bull s o t . c h i m Friijtce, [SI 17, 1091 (1950) An equivalent interpretation can, of course, be given in terms of structure X I . V I I . (49) L I Smith and W B Pings, J . Org. Chevz., 2 , 23 (1997).

DIAZOKETOKES WITH BASES

Oct. 5 , 1963

Experimentalso A. The Reaction of a-Diazoacetophenone with Methanolic Sodium Methoxide.-a-Diazoacetophenone (14.6 g., 0.10 mole) was dissolved in the minimal amount of dry methanol (20 ml., distilled from magnesium), and a solution of sodium methoxide prepared by dissolving sodium (2.4 g., 0.11 g.-atom) in dry methanol (15 ml.) was added dropwise with efficient stirring and ice-bath cooling. T h e reaction mixture rapidly acquired an intense winered color and effervesced slowly. Cautious addition of the methoxide solution and efficient ice-bath cooling were necessary in order t o prevent a violent, exothermic reaction resulting in vigorous frothing. After 30 min., the ice bath was removed, and the reaction was allowed t o proceed a t room temperature for a n additional 2.5 hr. The intensely red, opaque mixture was poured into a vigorously stirred mixture of ice and excess aqueous sodium bicarbonate, and the yellow-orange granular precipitate was collected, washed well with aqueous 5% sodium bicarbonate and water, drained and pressed thoroughly, and dried in a vacuum desiccator t o constant weight. The crude solid (11.0 9 . ) melted over a broad range, and had a readily detectable odor of methyl benzoate. Acid Fraction.-The sodium bicarbonate solution and washings were combined, washed once with dichloromethane, and acidified with concentrated hydrochloric acid. The yellow precipitate was washed with water, dried, and digested with dichloromethane. A pale yellow crystalline deposit of 3-benzoyl-S-hydroxy-4-phenylpyrazole (11) (400 mg., 37,), m.p. 248-250", was thus obtained. The aqueous filtrates were extracted with several portions of dichloromethane and the extracts were filtered through anhydrous sodium sulfate and evaporated t o dryness on the steam b a t h . The light brown residue (2.1 9 . ) crystallized on cooling; upon recrystallization from benzene it afforded light buff needles of 5-benzoyltetrazole (XXV) (870 mg., l o y o ) , m.p. 137-139". Evaporation of the mother liquors t o dryness gave a light brown solid (1.2 g.) with a n infrared spectrum showing all the bands characteristic of benzoic acid, in addition to weaker bands characteristic of XXV. Weak Acid Fraction.-The solid obtained on addition of the reaction mixture t o aqueous sodium bicarbonate was dissolved in a small amount of dichloromethane, and the solution was diluted with ether. The light brown precipitate (2.0 9 . ) was filtered and washed with ether. The filtrate and washings were extracted with several portions of cold aqueous 2% potassium hydroxide. The initial extracts were intensely red, while the final extracts were pale yellow-orange. The combined basic extracts were washed twice with ether and poured into cold, excess aqueous sodium bicarbonate with vigorous stirring. The yellow-orange granular precipitate was washed with water, pressed and drained thoroughly, and dried in a vacuum desiccator t o constant weight (5.4 g.). I t was dissolved in a small amount of benzene and the solution was allowed to stand a t room temperature for several days and then placed in the refrigerator for 1 week. A t a n , crystalline deposit of 3-benzoyl-4-hydroxy-5-phenylpyrazole(111) (530 mg., 4Vc), m.p. 207--209', was thus obtained. The mother liquors were boiled to dryness on the steam bath. The residue was heated on the steam bath for a further 30 min. and then dissolved in methanol. After prolonged standing a t room temperature, the solution deposited bright yellow needles of compound XLIII (500 mg., 5%), m.p. 198-201" dec. 4 n acetone solution of the residue obtained upon evaporation of the mother liquors slowly deposited a very small amount ( c a . 20 mg.) of an additional product as deep yellow, fluffy needles, m . p . 273-275" dec. Attempted isolation of further crystalline products from the remaining dark brown glass obtained upon evaporation of the mother liquors by attempted recrystallization from a variety of solvents, or by chromatography on Florisil, Woelrn alumina (neutral, Grade l), or silica gel was unsuccessful. .4 small amount of I (vide infra) could be obtained by elution with methanol from a column of strongly basic ion-exchange resin (Amberlite IRA-400 as the hydroxide) charged with a rnethanolic solution of' this residue; elution with methanolic sodium hydroxide or with methanolic hydrochloric acid did not effect further separation into pure components. The precipitate obtained earlier upon addition of ether t o the solution in dichloromethane of the bicarbonate-insoluble solid from the reaction mixture yielded a small amount of X L I I I upon crystallization from ether-methanol, but no further crystalline products could be isolated from the remaining resinous solid. Neutral Fraction.-The combined ethereal layer aiid washings from the extraction with aqueous potassium hydroxide were washed once with dilute aqueous sodium bicarbonate and once with saturated aqueous ammonium chloride, dried over sodium sulfate, and stripped of solvent. The resulting brown glass (2.9 9 . ) was extracted with several portions of boiling petroleum ether, and the insoluble residue was dissolved in a small amount of

-

( 5 0 ) Melting and boiling points are uncorrected. Infrared bands in the 5 and 6 p regions were calibrated against the bands of polystyrene film a t 5.14 and 6 24 p , respectively.

2973

benzene. The solution was chilled in the refrigerator for several days when it afforded a pale yellow crystalline deposit of 3benzoyl-4-phenylpyrazole (I) (125 mg., lYO), m.p. 192-193". The infrared spectrum of the residue from evaporation of the mother liquors included all the bands characteristic of I, b u t further crystalline material could not be separated. The oily residue (2.0 g.) obtained upon evaporation of the petroleum ether extracts had a strong odor characteristic of methyl benzoate and its infrared spectrum included all of the bands present in t h a t of tnethyl benzoate, in addition to weaker bands characteristic of a-diazoacetophenone. B. Purification and Characterization of Products. 3-Benzoyl5-hydroxy-4-phenylpyrazole (11).-Purification of I1 was effected by solution in boiling methanol, filtration of the hot solution through S o r i t , dilution of the filtrate with boiling water, and slow cooling of the solution t o 0". Several recrystallizations in this manner, or from chloroform-methanol, afforded analytical A,, samples as small, pale yellow needles, m . p . 248.5-250'; ( S u j o l ) 3.03, 3.18, 6.13, 6.50, 11.02 K ; Xma, (95'70 E t O H ) 251 mu (log e 4.30), 283 mp (log e 4.12), 340 m r (shoulder, log e 3.40); Xma, (0.1 N K0H-95y0 E t O H ) 251 mp (log e 4.31), 283 m,u (log c 4.22), 3.85 mp (log e 3.24). Anal. Calcd. for ClsH12N202: C, 72.71; H , 4.58; N , 10.60. Found: C, 72.83, 72.65; H , 4.84, 5.01; N , 10.62. T h e substance was soluble in dilute aqueous potassium carbona t e and gave a n intense red color with ferric chloride in chloroform containing pyridine. I t was shown t o be identical with t h e compound, C16Hi2N202, obtained by Yates and Shapiro' in the reaction of or-diazoacetophenone with sodium hydroxide in dilute solution by a mixture melting~. point determination and infrared spectral comparison. Oxidation of IT: Formation of IV.-To a slurry of comDound I1 (260 mg., 1.0 mmole) in dichloromethane ( 5 ml.), meihanol ( 2 ml.) was added. The solution was boiled gently, and 0.054 N perbenzoic acid in benzene (20 ml., 1.1 mmoles) was added. T h e undissolved solid slowly went into solution (ca. 15 min.) and boiling was continued for an additional 30 min. T h e solution was washed several times with aqueous 5Y0 sodium bicarbonate and once with saturated aqueous sodium chloride. I t was dried with anhydrous sodium sulfate, concentrated on the steam b a t h , diluted with hexane to the cloud point, and chilled. There was deposited a faintly yellow amorphous powder (180 mg.), Amax (Nujol) 3.13, 3.25, 5.68, 6.04 K. This was dissolved in hot ether (ca. 5 ml.) and the solution was concentrated on the steam bath until crystallization began. Cooling t o -25" afforded very faintly yellow rhombs of IV (41 mg., 147,): m.p. 158-160'. Two recrystallizations from carbon tetrachloride-ether afforded an analytical sample, m . p . 169-171' (dried for 20 hr. at 25" and 0.2 mrn. over phosphorus pentoxide); A, (Nujol ) 3.13, 3.25, 5.68, 6.04, 9.1 p . Anal. Calcd. for C ~ Z H Z ~ N ~ O ~ . G C H, I ~ 71.98; O: H , 5.37; pl;, 9.33. Found: C , 72.48; H , 4.96; N , 9.33. Attempted recrystallization from carbon tetrachloride alone gave only an amorphous powder, while the addition of ether t o the hot carbon tetrachloride solution followed b y slow cooling of the mixture resulted in the separation of colorless rhombs. Oxidation of I1 with potassium permanganate in aqueous base, with bromine in acetic acid, or with potassium ferricyanide in aqueous ethanol led t o crude products with infrared spectra identical with t h a t of t h e crude IV obtained above. 5-Benzoyltetrazole (XXV).-Several recrystallizations of crude XXV from benzene afforded an analytical sample as colorless needles, m.p. 139.5-140°; A, (CHdJ.2) 2.95, 6.00, 10.85 p ; A,,,(Nujol)3.70, 3.83, 6.03, 1 0 . 8 0 ~ . Anal. Calcd. for CsH6NdO: C , 55.17; H , 3.47; N , 32.17; mol. wt., 174. Found: C, 55.34; H , 3.32; X, 32.23; neut. equiv., 175, 176. The substance was slightly soluble in water, dissolved readily in cold, dilute, aqueous sodium bicarbonate with gas evolution, and gave a negative color test with ferric chloride in ethanol or in chloroform-pyridine. Solution in concentrated sulfuric acid followed by heating on the steam bath resulted in the slow evolution of a gas; decomposition was cotnplete in 12 hr. with the formation of benzoic acid, identified by comparison with an authentic sample. Methylation of XXV.-Compound XXV (124 mg., 0.7 mmole) was dissolved in a few ml. of ether, and a solution of diazomethane in ether was added slowly with swirling until gas evolution ceased and t h e yellow color of diazomethane persisted. The solvent was evaporated on the steam bath and the residual oil was chilled and scratched to initiate crystallization. The almost colorless crystalline solid upon recrystallization from ether afforded faintly yellow rhombs (74 mg.? 56y0),m.p. 80.5-81.5". Several recrystallizations from hexane yielded an analytical sample (CHZC12) 5.99, 10.88 p . as colorless rhombs, m.p. 83-83.5'; A,, A n a l . Calcd. for CsH,S,O: C , 57.44; H, 4.29; S , 29.77. Found: C, 57.63; H, 4.33; K, 30.13, 29.86.

2974

PETER YATES AND

DONALD G. FARNUM

3-Benzoyl-4-hydroxy-5-phenylpyrazole (111) could be recrystallized from chloroform-methanol to give pale yellow, fluffy needles, m . p . 210-210.5°; ,,,A, ( S u j o l ) 2.97 ( s ) , 3.07 ( w ) , 6.16, 8.60, 10.28, 11.05 p , or from benzene t o give pale yellow rhombs, m.p. 210-210.5°; , , ,A (Xujol) 2.95 ( w ) , 3.05 ( s ) , 6.14, 8.55, 10.90 p ; , , ,A (9554E t O H ) 243 mp (shoulder, log e3.98), 274 mp(log r4.49), 285 mp (shoulder, log e 4.41), 345 mp (log e 3.32); ,,,A (0.1 A' KOH-EtOH) 242 mp (log E 4.181, 290 nip (loge4.22), 410mp(log e 3.89). Anal. Calcd. for C16H12~202: C, 72.71; H , 4.58; X , 10.60. Found: C , 72.75, 72.69; H , 4 . 9 8 , 4 . 8 9 ; N,10.87. Samplefrom benzene: C, 73.33; H,4.59; N,10.64. The substance was soluble in dilute aqueous sodium hydroxide to give a yellow solution, b u t only very slightly soluble in dilute aqueous sodium carbonate. I t gave an intense, blue-green coloration with ferric chloride in ethanol or in chloroformpyridine . Compound XLII1.-Purification of X L I I I could be effected by recrystallization from 95% ethanol t o give long, bright yellow needles, m.p. 202-203" dec., exhibiting a blue-green fluorescence under ultraviolet illumination. Several recrystallizations of this material from benzene afforded an analytical sample as golden yellow leaflets, m.p. 203-204" dec., with a blue-green fluorescence in the ultraviolet light;, , ,A (KBr or Xujol) 6.07, 6.50, 11.00 p ; , , ,A ( C H 3 0 H ) 240 mp (log c 4.32), 283 mp (log e 4.36), 363 m p (log e 3.99);, , ,A (50% H Z S O ~252 ) mp (log e 4.40), 360 mp (log e 4.43); Ama, (H2SOd) 240 m p (log e 3.85), 300 mp (log e 3.67), 362 mp (log e 4.28), 420 mp (log e 4.64). Anal. Calcd. for C17HllKSO: C, 67.76; H , 3.68; N, 23.23. Found: C, 67.98, 67.83; H , 3.99, 3.57; h', 23.44. T h e substance was insoluble in dilute aqueous sodium hydroxide, dissolved in cold, 50yGaqueous sulfuric acid to give a colorless, nonfluorescent solution or in concentrated sulfuric acid t o give a yellow-orange solution with a pale green fluorescence in ultraviolet light and was regenerated upon dilution of these solutions with ice-water. Boiling a solution of a small sample of X L I I I in acetic acid-concentrated hydrochloric acid for 30 min. gave a nonacidic, colorless oil; Amax (CH2C12)6.46, 6.62, 10.05 p , exhibiting a blue fluorescence under ultraviolet light, and benzoic acid, identified by infrared spectral comparison with an authentic sample. Base Hydrolysis of XLIII: Formation of XXXV.-Compound X L I I I (270 mg., 0.9 mmole) was dissolved in boiling 95'/;? ethanol (20 ml.), aqueous 40% potassium hydroxide ( 2 ml.) was added, and boiling was continued for ca. 5 min. The deep orange solution was rapidly cooled, acidified with acetic acid, and poured into aqueous 57' sodium bicarbonate. The precipitated solid was collected and recrystallized from ethyl acetate. Compound XXXV was thus obtained as fluffy, white needles (60 mg., 25YC,), m.p. 266-268' dec., with a n intense yellow-green fluorescence in ultraviolet light. Samples for analysis (m.p. 266-268" dec., A,, (Nujol) 3.12, 5.97, 6.11, 6.30, 10.70 p ; , , ,A (CH30H) 247 mp (log e 4.29), 304 mp (log e 4.19); Amax (270 NaOH-CH30H) 248 mp (log e 4.30), 326 mp (log e 4.09)) were prepared by recrystallization of the product from ethyl acetate or from acetone957' ethanol. Anal. Calcd. for Cl6Hl2X4O2:C, 65.75; H , 4.14; 9,19.1'7. Found: C, 66.09, 65.96; H , 4.35, 4.07; K,18.82, 18.72, 19.37. The substance was soluble in dilute aqueous sodium hydroxide, gave no color reaction with ferric chloride in ethanol or in chloroform-pyridine, and was recovered unchanged after treatment with sodium nitrite and concentrated hydrochloric acid in dioxane. A deep red color was formed after protracted warming with acidified p-dimethylaminobenzaldehyde in ethanol. Prolonged boiling of solutions of the compound in hydrochloric-acetic acid, or brief boiling in ethanolic potassium hydroxide, led to extensive decomposition with t h e formation of benzoic acid, which was the only nonvolatile bicarbonate-soluble product. 3-Benzoyl-4-phenylpyrazole ( I ) , m.p. 193-194', , , ,A (Sujol) 3.25,6.06, 10.88 M , was identified by comparison with an authentic sample',49(lit.1 m.p. 193-194'). C , Synthetic Experiments. 3-Benzoyl-5-hydroxy-4-phenylpyrazole (11) (and Compounds X and XIV).-The higher melting epimer of methyl a-phenyl-P-bromo-@-benzoylpropionate'" ( 1.04 g., 3.0 mmoles) was dissolved in warm 95qc ethanol (ca. 25 ml.). A slurry of sodium carbonate (500 mg.) in a solution of 9356 hydrazine (0.2 ml.) in 95Yc ethanol ( c a . 5 ml.) was added, and the mixture was boiled gently on the steam bath for 30 min. in a slow stream of air. The deep yellow mixture was then diluted with aqueous 5Yc sodium carbonate, washed once with dichloromethane, and neutralized with concentrated hydrochloric acid. The precipitate was extracted with ethyl acetate and the extracts were dried over sodium sulfate and boiled to dryness on the steam bath. The residue was taken up in dichloromethane and chilled t o 0'. The pale yellow needles (100 mg., 13%), m.p. 252-254", which deposited were shown t o be identical with I1 by a mixture melting point determination and infrared spectral comparison.

VOl. 85

The dichloromethane filtrate, upon prolonged standing, deposited colorless rhombs of compound X (200 mg., 25(,&), which, upon recrystallization from chloroform-methanol, afforded a sample for analysis as colorless, square plates, m . p . 15%155' dec.; , , ,A (Sujol) 3.00, 4.0 (broad), 5.30 (broad, weak), 5.90, 6.30, 6.42, 7.90, 11.15, 13.2 p . Anal. Calcd. for ( C I ~ H ~ ~ ~ Z ~ Z ) ZC. ,C61.07; H C I ~ H: , 4.47; N , 8.63. Found: C, 61.07; H , 4.57; N, 8.93. This substance dissolved in dilute aqueous sodium bicarbonate with gas evolution. Dropwise addition of bromine t o this solution resulted in the formation of a faintly yellow precipitate which, upon recrystallization from 93% ethanol, yielded colorless rhombs, m . p . 203-204", identified as 3,5-diphenylpyrazole (lit.'3 m.p. 200') by a mixture melting point determination and infrared spectral comparison with an authentic sample.13 The dichloromethane extracts of the original reaction mixture were extracted with several portions of aqueous 27' sodium hydroxide, and the extracts were acidified with concentrated hydrochloric acid. The resultant precipitate, upon recrystallization from 95Yc ethanol, afforded faintly yellow needles of 3,sdiphenyl-6-pyridazinone (XIV) (370 mg., 30c/,), m . p . 185.5186.3°, identified by a mixture melting point determination and infrared spectral comparison with an authentic sample ( o d e infra). 4,5-Dihydro-3,5-diphenyl-6-pyridazinone(XXIII)18 was obtained in quantitative yield from a-phenyl-P-benzoylpropionic acid and hydrazine a s colorless needles, m . p . 166.5-167' (lit.1a (9596 m.p. 164'); X,,,(Sujol) 3.08, 3.20, 5.98, 8.00 p ; A,,, EtOH) 288 mp (log e 4.21). 3,5-Diphenyl-6-pyridazinone (XIV) was prepared in quantitative yield by oxidation of the dihydro compound X X I I I with one molar equivalent of bromine in acetic acid a t room temperature: m.p. 185.5-186.5" (lit.15m.p. 184'), Ama,(CH2C12) 2.95, 6.05 p . N-Amino-2,4-diphenyl-3,4-dihydroxybutyrolactam (XVIII).a-Phenyl-@-benzoylpropiolactone (low melting epimer)I6 was obtained in 73-5: yield as long, colorless needles, m.p. 9 3 . 5 9 4 ' ( l i t . ' 6 m.p. 9~ ) ; Amnx (CH2C12) 5.41, 5.87, 9.0 p . The lactone (5.04 g., 0.020 mole) was dissolved in benzene ( c a . 35 ml,), and a loc,; solution of anhydrous hydrazine in methanol (6.4 mi., 0,020 mole) was added dropwise to the swirled solution. Colorless needles began to separate when addition neared completion (warming was evident). The mixture was digested for ca. 5 min. on the steam bath and cooled t o room temperature. The resulting white needles (5.32 g., 94%), m . p . 1 5 7 . 5 1 5 9 ° dec., upon recrystallization from nitromethane afforded an analytical sample, m.p. 154-155.5' dec.; Xm, (Nujol) 2.90 (broad), 5.82, 6.1, 9.05p;, , ,A (dioxane) ca. 215mp; , , ,A (2% NaOH-dioxane) ca. 215 mg. Anal. Calcd. for C16H&203: C , 67.59; H , 5.67; N,9.85. Found: C , 67.2'7; H , 5.78; h', 10.00. When acetonitrile rather than benzene was used as solvent the same product was obtained. However, it was soluble in this medium and was isolated by concentration of the reaction mixture on the steam bath and dilution with hexane. The yield was comparable to t h a t obtained with benzene as solvent. The product gave no color reaction with ferric chloride in ethanol or in chloroform-pyridine, was insoluble in dilute aqueous sodium carbonate, but gave a colorless solution with cold, dilute aqueous sodium hydroxide from which it was reprecipitated unchanged by the addition of saturated aqueous sodium bicarbonate. I t was soluble in concentrated hydrochloric acid, insoluble in dilute hydrochloric acid, and, with dry hydrogen chloride in dioxane, gave a colorless, crystalline precipitate ( X I X ) , dec. m. (Nujol) 2.88, 3.05, 3.7, 5 75, 9.0 p . Addition of this 240'; A, precipitate t o dilute aqueous sodium bicarbonate regenerated XVIII. Reaction with sodium nitrite and hydrochloric acid in aqueous dioxane resulted in vigorous gas evolution. Benzylidene Derivative of XVII1.--A solution of X V I I I in hot 95'3 ethanol was treated with benzaldehyde and a little sodium acetate. The solution was boiled briefly, diluted with water, and cooled. The resulting viscous oil was extracted into dichloromethane, and the organic extracts were filtered through sodium sulfate and evaporated to dryness. The residual viscous oil, upon crystallization from benzene-hexane, afforded colorless rhombs, dec. ca. 2-10', Several recrystallizations from ethanol gave a sample for analysis as colorless rhombs, dec. ca. 240"; A,", (CH2C12) 2.85, 3.0( w ) , 5.88, 9.05, p . Anal. Calcd. for Cy3H20?.T?Os:C , 74.17; H , 5.41; N, 7 . 5 2 . Found: C , 74.04; H , 5 58; N, 7.47. 4,5-Dihydro-4-hydroxy-3,5-diphenyl-6-pyridazinone (XXIII .--A solution o f X V I I I in hot nitrornethane (500 mg., 1.75 mnloles) was boiled under reflux for 1 hr. The resultant solution was concentrated t o a small volume, and the remainder o f the solvent was removed under reduced pressure. The residual glass was crystallized from 95?,; ethanol t o give fainotly yellow rhombs of X X I I (300 mg., 657%), m.p. 156-157.5 . Recrystallization from 95c/, ethanol afforded an analytical sample as colorless

Oct. 5, 1963

DIAZOKETONES WITH BASES

rhombs, m.p. 157-158O; Amax(Nujol)2.95, 3.10, 3.20, 5.97, 7.98, 9.25 p ; , , ,A (95% EtOH) 288 mp (log e 4.20). Anal. Calcd. for CleHiaN202: C , 72.16; H , 5.30; N, 10.52. Found: C, 72.15; H , 5.21; N,10.42. Treatment of a boiling, alcoholic solution of this substance with a little hydrochloric acid, dilution of the resultant solution with water, and cooling, afforded a crystalline deposit of 3,5-diphenyl6-pyridazinone ( X I Y ) , identified by a mixture melting point determination and infrared spectral comparison with a n authentic sample ( m d e supra). Acid Treatment of XVIII : Formation of 3,s-Diphenyl-6pyridazinone (XIV).-Compound X V I I I (200 mg., 0.70 mmole) was dissolved in a few ml. of boiling 9570 ethanol, concentrated hydrochloric acid ( 1 ml.) was added, and the hot solution was diluted to the cloud point with water. Chilling t o 0" caused t h e separation of colorless needles (160 mg., 92'%), m.p. 185.5186.5'; , , ,A (CHzC12) 2.95, 6 . 0 5 ~ . This substance was shown as above to be identical with authentic 3,5-diphenyl-6-pyridazinone. 4-Hydroxy-3,5-diphenyl-6-pyridazinone (XV).--A solution of bromine ( 160 mg., 1.O mmole) in dioxane was added dropwise t o a cold solution of X X I I (270 mg., 1.0 mmole) in dioxane. The resultant mixture was allowed t o stand a t room temperature for 1 hour, then poured into water. The precipitate thus obtained was extracted into ethyl acetate containing 2076 methanol. The organic extracts were dried over sodium sulfate and concentrated on the steam bath until colorless crystals of XV separated. This crude product ( T O mg., 2676), m.p. ca. 300" dec. upon recrystallization from nitromethane, afforded a sample for analysis, m . p . ca. 300" dec.; A,, (Nujol) 3-4 (broad), 6.15, 6.32, 6.38, 6.52 p . Anal. Calcd. for C I ~ H I ~ S Z O C,P 72.71; : H , 4.58; N,10.60. Found: C, 72.95, H , 4.67; N , 10.70. This substance dissolved in dilute, aqueous sodium hydroxide and was recovered from the solution upon acidification. I t gave a red color with ferric chloride in chloroform containing pyridine. 5-Benzoyltetrazole (XXV).-5-Benzyltetrazole, m.p. 123.5124 5' (lit.25m . p . 123-125"), Amax ( S u j o l ) 3.75, 3.90, 6.45, 6.52 bv the method of Finnegan, .U ._ was synthesized in 78%_ vield _ Henry, and L o f q ~ i s t . ~ ~ 5-Benzyltetrazole (6.4 g., 0.04 mole) was dissolved in warm acetic acid (ca. 10 ml.), and a solution of chromium trioxide (6.0 g., 0.06 inole) dissolved in a few ml. of water was added cautiously with intermittent cooling in an ice bath. Concentrated sulfuric acid ( 5 ml.) was added dropwise with cooling and swirling, and the solution was kept a t room temperature for 10 hr. The resulting green solution and green precipitate were washed into ice-water and the mixture was stirred t o dissolve t h e inorganic material. T h e clear, green solution was extracted several times with dichloromethane (300 ml. in all). The extracts were filtered through anhydrous sodium sulfate and concentrated on the steam bath to ea. 10 ml. Dilution of the hot solution t o ca. 50 ml. with carbon tetrachloride and seeding with a crystal of X X V caused the immediate separation of a copious precipitate. T$ mixture was digested briefly on the steam bath, chilled t o - 10 , and the colorless leaflets were collected and air-dried. The product thus obtained (4.6 g., 66y0),m.p. 136-137", was shown to be identical with XXL' by a mixture melting point and infrared spectral comparison. The methyl derivative, prepared with diazomethane, was likewise shown to be identical with t h a t of XXY (aide supra). 3-Amin0-5-benzyl-1,Z ,4-triazole (XXXVII).-hninoguanidine bicarbonate (18.6 g., 0.1 mole) was added in small portions t o concentrated sulfuric acid (12 ml., 0.22 mole). The resulting pasty mass was stirred and broken up, and phenylacetic acid (15 g . , 0.11 mole) and water (ea. 5 ml.) were added. The hot mixture was then brought to ca. 140' b y immersion of the reaction vessel in refluxing xylene vapors, and maintained a t t h a t temperature for 48 hr. Loss of phenylacetic acid by sublimation was compensated by the periodic addition of further portions of phenylacetic acid (totaling ea. 10 g.). The reaction mixture was then cooled below looo, diluted with water, and poured slowly into excess, dilute, aqueous potassium carbonate. The resultant mixture was extracted with several portions of 2OyG methanol807' ethyl acetate (totaling 1 I . ) . The organic extracts were dried over sodium sulfate, filtered, concentrated on the steam bath until crystallization began, and then chilled t o 0'. The resultant colorless needles (7.0 g., 40%), m.p. 169-169.5', upon recrystallization from methanol-ethyl acetate afforded a n analytical sample, m . p . 169-169.5'; Amn, (Xujol) 2.90, 3.0, 6.18, 6.00 p . A n d . Calcd. for CsH,&r: C , 62.05; H, 5.79; N , 32.17. Found: C, 62.19; H , 5.96; N , 32.12. Diazotization of a small sample of the product with sodium nitrite in cold, concentrated hydrochloric acid afforded a colorless, crystalline precipitate. Addition of this slurry to a solution

2975

of @-naphtholin dilute aqueous base gave an intensely red solution. Substitution of mandelic acid for phenylacetic acid in this procedure led t o extensive decomposition with t h e formation of much tarry material. Substitution of polyphosphoric acid for sulfuric acid gave little or no reaction, while the use of slightly more than an equivalent of nitric acid rather than sulfuric acid according t o the general method for the synthesis of 3-amino1,2,4-triazole derivatives resulted in violent decomposition with t h e formation of dark tars. 3-Benzamido-5-benzyl-1,2,4-triazole(XXXIX) and XXXVII1,Compound X X X V I I (3.5 g . , 0.02 mole) mas dissolved in cold, dry pyridine (ca. 50 ml.), and benzoyl chloride ( 5 ml.) was slowly added to the swirled solution. After 10 min., the mixture was poured into dilute aqueous potassium carbonate, and the mixture was stirred a t room temperature for 30 rnin., then chilled in t h e refrigerator. The resultant colorless, granular precipitate (5.4 g., 97Y0) was washed well with cold water. The product partially melted a t 150", then resolidified and melted a t 280-281" dec. Recrystallization of a portion of the product from aqueous acetic acid afforded colorless needles of X X X I X , m . p . 281-282'. T h e mother liquors, upon dilution with water and chilling, afforded colorless needles of X X X V I I I , m.p. ea. 140°, resolidifying and melting at 281-282". The crude product (500 mg.) was heated above 150" for a few minutes until the initial melt had resolidified and then digested in ethyl acetate. The insoluble, colorless needles thus obtained (500 mg., 1007G),m . p . 281-282", were identical with the product of m.p. 281-282" obtained above. Recrystallization of a sample of XXXIXo from 95Oj, ethanol afforded an analytical sample, m.p. 284-285 ;, , ,A (Nujol) 3.2, 5.96, 6.35, 6 . 4 5 , ~ . Anal. Calcd. for C~H14N40: C , 69.05; H , 5.07; N, 20.13. Found: C, 68.78; H , 5.18; N, 20.12. Several recrystallizations of a sample of X X X V I I I from benzene-hexane afforded an analytical sample, m . p . 142.5-143': , , ,A (Nujol) 2.95, 3.10, 5.90, 6.08, 6.45 U . Anal. Calcd. for C I ~ H I ~ S ~C O , 69.05; : H , 5.07; N, 20.13. Found: C,68.82; H , 5.20; S,19.87. 5-Benzamido-3-benzoyl-l,2,4-triazole(XXXIV).-Compound XXXIX (280 mg., 1.0 mmole) was dissolved in the minimal amount of acetic acid (ca. 3 ml.) at room temperature. A solution of chromium trioxide (150 mg., 1.5 mmoles) in a little water was added, followed by concentrated sulfuric acid ( 5 drops). A small portion of the solution was withdrawn, heated strongly on the steam bath until precipitation of green chromic sulfate was evident, then returned t o the main reaction mixture. T h e solution was maintained a t 40" overnight, during which time the precipitation of a mixture of colorless needles and green solid took place. The reaction mixture was diluted with water (ea. 15 ml.) until all the green chromic sulfate dissolved, then chilled. The resulting colorless nonfluorescent needles (290 mg., looc&), m.p. 249-249.5', upon recrystallization from 95'7; ethanol afforded an analytical sample, m.p. 251.5-252'; A,, , (Nujol) 2.95, 3.15, 5.90, 6.00, 6.23, 10.82 M . Anal. Calcd. for C I ~ H I ~ K ; ~CO, Z65.75; : H , 4.14; N, 19.17. Found: C,65.59; H , 4.24; N , 19.26. 5-Amino-l,4-dibenzyl-l ,2,3-triazole (XL).--4 solution of hydrocinnamonitrile (5.2 g., 0.04 mole) in a little ether was added slowly t o a refluxing, stirred suspension of sodium amide (1.8 g., 0.046 mole) in ether (100 ml.). T h e mixture was stirred under reflux for 30 min., then benzyl azide (5.2 g., 0.04 mole) in a little ether was added dropwise. The mixture was stirred under reflux for 40 hr. Infrared inspection of the ethereal solution indicated no change in the intensity of the absorption at 4.8 p characteristic of benzyl azide. T h e ether was then displaced with diisopropyl ether by distillation through t h e condenser, and the mixture was boiled under reflux for 1 week (infrared spectral inspection of the material obtained from evaporation of an aliquot of the supernate indicated the presence of ea. 40% unconsumed benzyl azide). The reaction mixture was poured into ice-water, the residue was washed into the aqueous mixture with methanol, and the organic layer was separated. The aqueous layer was extracted with dichloromethane, and the combined organic fractions were dried over sodium sulfate and evaporated t o dryness on the steam b a t h . T h e residue was dissolved in a n ether-benzene mixture, 70% perchloric acid ( e a . 5 ml.) was added slowly with cooling, and the mixture was kept overnight a t room temperature. --The supernate was decanted from the gummy residue, which was washed with benzene. The residue was stirred with excess dilute aqueous potassium hydroside, and the precipitated gummy solid was extracted with dichloromethane. The dichloromethane extracts were dried over sodium sulfate and evaporated to dryness on the steam b a t h ; the residue was crystallized from benzene. Light buff needles (2.5 g . , 24y0), m.p. 133-13i0, were thus obtained. Several recrystallizations from benzene afforded a n analytical sample, m . p , 139.5-140'; Amax (CHzCIz) 2.85, 2.95, 6.08 p .

2976

GLENA. RUSSELL, AKIHIKOITO,

Anal. Calcd. for Cl6HlsN4: C , 72.70; H , 6.10; K, 21.20. Found: C, 72.33; H , 6.42; N,21.00. Attempts to carry out this condensation with potassium tbutoxide in t-butyl alcohol, or with sodium ethoxide in ethanol, were ineffectual. Infrared inspection of aliquots of the reaction mixtures even after several weeks a t the reflux temperature indicated the presence of c a . 90% unconsumed benzyl azide. Gradual addition of a solution of a slight excess of potassium t-butoxide in tetrahydrofuran (freshly distilled over lithium aluminum hydride) t o a cold equimolar mixture of hydrocinnamonitrile and benzyl azide in tetrahydrofuran according t o the general procedure of Lieber, et led t o the formation of a product (SOYc, if assumed t o be the Thorpe condensation product of hydrocinnamonitrile), m . p . 88-90"; A, (CH2C12) 2.95, 3.01, 4.50, 6.25 (complex) p . 5-Benzamido-l,4-dibenzyl-l,2,3-triazole (XLI).-Benzoyl chloride (0.3 ml., 2.2 mmoles) was added dropwise to a cooled solution of the aminotriazole X L (5.30 mg., 2.0 mmoles) in pyridine ( c a . 5 ml.). The mixture was kept a t room temperature for 30 min., poured into dilute hydrochloric acid, and the precipitated solid was collected. Recrystallization from benzenehexane afforded colorless needles of X L I (500 mg., 68y0),m.p. 1;i-178°. Several recrystallizations from benzene-hexane afforded a n analytical sample, m.p. 178.5-179'; Amax (CH2C12) 2.95, -5.91, 6.25, 6.69, 6.87 /A. Anal. Calcd. for C23HzoS40: C , 74.98; H, 5.47; N, 15.21. Found: C, 74.90; H,5.25; N,14.96. 5-Benzamido-4-benzoyl-l-benzyl-l,2,3-triazole(XLII).-A solution of chromium trioxide (140 mg., 1.4 mmoles) in a little water was added to a warm solution of the benzamidotriazole XLI (370 mg., 1.0 mmole) in acetic acid ( c a . 5 ml.). T h e mixture was cooled, and concentrated sulfuric acid (10 drops) was added. h small sample of the mixture was withdrawn, heated strongly on the steam bath until a green precipitate was observed, then returned t o the reaction mixture. After 6 hr. a t room temperature, the mixture of white crystals and green precipitate was diluted with water, stirred to effect solution of inorganic salts, and the white needles of X L I I (380 mg., 100%) were collected and washed well with water. Several recrystallizations from benzene afforded a n analytical sample, m.p. 201.5-202'; , , ,X (Kujol) 3.12, 6.05, 6.12, 10.82 /A. Anal. Calcd. for C23Hi8S402: C, 72.23; H, 4.74; N , 14.65. Found: C, 72.11; H , 4 . 7 4 ; N, 14.43.

[CONTRIBUTIOS FROM

THE

AND

DALEG. HENDRY

VOl. 85

Attempted hydrogenolysis of this substance in ethanol in the presence of acid-washed lOyGpalladium-charcoal catalyst a t room temperature and atmospheric pressure resulted in the uptake of more than one equivalent of hydrogen without a sharp break in the hydrogenation curve. T h e crude product obtained upon evaporation of the solvent, after removal of an insoluble hydroxyl-containing component (A,, (Nujol) 2.88, 3.07, 5.95, 6.26, 9.60 p ) by crystallization from ethanol, exhibited an infrared spectrum identical with t h a t of X L I . Chromic acid oxidation of the total crude product according to the procedure used above quantitatively regenerated X L I I . Addition of a large excess of metallic sodium, in sniall portions, t o a stirred slurry of X L I I in liquid ammonia resulted in the formation of a transient chocolate-brown coloration and a yellow precipitate. Isolation of the organic product from this reaction by the addition of excess solid ammonium chloride, evaporation of the solvent, and extraction with boiling ethanol afforded a 9O"/b recovery of X L I I . A solution of X L I I and excess potassium thiocyanate in hot 95yGethanol was boiled under reflux for 24 hr. Vpon cooling of the solution, X L I I was quantitatively recovered as a deposit of colorless needles. A solution of X L I I in hot, concentrated hvdriodic acid was boiled under reflux for 1 h r . The fluorescent organic material isolated from this reaction mixture by dilution with water and extraction with ethyl acetate showed, in its infrared spectrum, all of the characteristic bands of X L I I and only weak absorption characteristic of X X X V . 4-Benzamido-5-benzoyl-l,2,3-triazole(XXXV).--A solution of chromium trioxide (140 mg., 1.4 mmoles) in a little water was added t o a slurry of the benzoyltriazole XLII (380 rng., 1.0 mmole) in acetic acid ( c a . 5 ml.). Concentrated sulfuric acid (10 drops) was then added, and a small portion o f the mixture was withdrawn, heated strongly on the steam bath, and returned t o the main reaction mixture. After 1 week a t room temperature, the resultant suspension containing white crystals and green solid was diluted with water, stirred to effect solution of the inorganic material, and allowed to stand overnight a t room temperature. The faintly yellow, crystalline precipitate thus obtained was recrystallized from ethyl acetate to give faintly yellow needles (80 mg., 2 7 7 , ) , m.p. 266-268", exhibiting a bright yellowgreen fluorescence under ultraviolet light. The melting point of this product was undepressed upon admixture with S X X \ . and the infrared spectra (Nujol) of the two products were identical.

DEPARTMENT O F CHEMISTRY, IOWA STATE UNIVERSITY, AMES, IOWA]

Solvent Effects in the Reactions of Free Radicals and Atoms. VIII. The Photochlorination of Aralkyl Hydrocarbons132 BY GLENA.

RUSSELL,3

AKIHIKOITO,

AND

DALEG . HENDRY

RECEIVED APRIL 1, 1963 In the side-chain photochlorination of aralkyl hydrocarbons, high selectivity is often observed because of complex formation between the aromatic nucleus and the chlorine atom. This complexed chlorine atom displays considerably greater selectivity in hydrogen abstraction reactions than the free chlorine atom Dilution of aralkyl hydrocarbons by inert noncomplexing solvents destroys the high selectivity often noted in photochlorination. Extrapolation of selectivity d a t a to an infinite dilution of the aralkyl hydrocarbon yields reactivity data toward the free chlorine atom.

Previous communications have emphasized the importance of specific solvent effects, particularly of aromatic solvents, in the reactions of chlorine atoms.4 This has prompted us to re-examine the photochlorination of aralkyl hydrocarbons since in these cases the substrate itself could also act as a specific complexing agent for the chlorine a t o m 5 The results obtained have

(1) Directive Effects in Aliphatic Substitutions. P a r t XX. ( 2 ) This research was supported by t h e Air Force Office of Scientific Research and by a g r a n t from t h e Petroleum Research F u n d administered b y the American Chemical Society. G r a t e f u l acknowledgment is hereby made t o t h e donors of these funds. ( 3 ) Alfred P. Sloan Foundation Fellow, 1959-1963. (4) G A Russell, J . A m Chem. S o t . . 79, 2977 (1957); 80, 4987, 4997, 3002 (1938) ( 5 ) G . A Russell and H . C . Brown, zbid., 7 7 , 4031 (1955):

been in complete agreement with those obtained in a study of solvent effects in the photochlorination of aliphatic substances. Thus, the addition of an aromatic solvent in the photochlorination of a branched-chain hydrocarbon, such as 2,3-dimethylbutane, makes the chlorine atom more selective in its attack on the 3'and 1'-hydrogen atoms, the effect becoming more pronounced a t the higher concentration of aromatic ~olvent.~ I n the chlorination of aralkyl hydrocarbons, such as ethylbenzene, cumene, indan, and tetralin, the present work has demonstrated the same effect. Dilution of the aralkyl substrate by an aliphatic solvent, such as carbon tetrachloride or cyclohexane, or by a weakly basic aromatic such as nitrobenzene, has a pronounced effect on the reactivity of the chlorine atom, dilution favoring a lower selectivity in the attack of the chlorine atom upon a system of l o - , 2'-, and :