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Preface Fluoroorganic chemistry, a very important area of research, has attracted agricultural, materials, medicinal, and organic chemists alike. The recent flux of activities is well documented by several monographs and special issues of journals dedicated to this area. Due to the importance of enantiomerically pure pharmaceuticals, asymmetric organic synthesis has attracted the attention of organic and medicinal chemists alike. A combination of fluoroorganic and asymmetric synthesis has very great potential. This idea led to a symposium dedicated to the topic of Asymmetric Synthesis of Fluoroorganic Compounds that was held during the 216 National Meeting of the American Chemical Society ( A C S ) in Boston, Massachusettes, August 23 and 24, 1998. The symposium, sponsored by the A C S Divisions of Fluorine Chemistry and Organic Chemistry, was well received by organic chemists from both industry and academia and acted as a catalyst for this book. th
This volume contains twenty chapters by leading fluoroorganic chemists worldwide who participated in the symposium. The book is organized into sections based on the symposium. One of the pioneers of asymmetric fluoroorganic chemistry, Robert Filler wrote the lead chapter discussing fluorine-containing chiral compounds of biomedical interest, which is followed by chapters discussing reagent- and substrate-controlled asymmetric synthesis, the synthesis of fluorinecontaining target molecules, bioorganic synthesis, asymmetric fluoroorganic compounds in materials chemistry, agrochemistry, and pharmacy. This book, which discusses the current state of the art in asymmetric fluoroorganic chemistry is intended for organic, materials, and medicinal chemists in academia and industry. This volume can be adapted for a graduate course in fluoroorganic chemistry.
Acknowledgments I acknowledge all of the speakers who participated in the symposium, especially those who contributed to this volume. I thank Herbert C. Brown for his support and advice throughout the organization of the symposium and the production of this book. I thank the A C S Divisions of Fluorine Chemistry and Organic Chemistry for sponsoring the symposium. Financial support to the symposium by the A C S Corporate Associates and A C S Petroleum Research Fund are gratefully ix
Ramachandran; Asymmetric Fluoroorganic Chemistry ACS Symposium Series; American Chemical Society: Washington, DC, 1999.
acknowledged. Financial support from the following companies also contributed to the success of the symposium: Dow Agrosciences, Monsanto Company, Aldrich Chemical Company, Inc., Eastman Kodak Company, Schering-Plough, Merck Research Laboratories, Central Glass International Inc. (Japan), Daikin Industries (Japan), Kanto Denka Kogyo Company (Japan), and Asahi Glass Company (Japan). I acknowledge the help provided by Venkat Ram Reddy during the editing process of the book. Last, but not least, I thank the A C S Books Department Staff, particularly Anne Wilson and Kelly Dennis, for their remarkable efforts in the production of this book.
Downloaded by 80.82.77.83 on January 2, 2018 | http://pubs.acs.org Publication Date: December 29, 1999 | doi: 10.1021/bk-2000-0746.pr001
P. V . R A M A C H A N D R A N
Department of Chemistry Purdue University West Lafayette, I N 47907-1393
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Ramachandran; Asymmetric Fluoroorganic Chemistry ACS Symposium Series; American Chemical Society: Washington, DC, 1999.
