J. Nat. Prod. 2007, 70, 1429–1433
1429
Cardenolides from Saussurea stella with Cytotoxicity toward Cancer Cells Tian-Min Wang,† Toshinari Hojo,‡ Fu-Xiang Ran,† Ru-Feng Wang,† Rui-Qing Wang,† Hu-Biao Chen,*,†,§ Jing-Rong Cui,† Ming-Ying Shang,† and Shao-Qing Cai*,† The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking UniVersity Health Science Center, Beijing 100083, People’s Republic of China, ARSOA Honsha Corporation ARSOA R&D Center, Yamanashi, Japan, and School of Chinese Medicine, Hong Kong Baptist UniVersity, Hong Kong, People’s Republic of China ReceiVed April 3, 2007
Three new cardenolides, 3-O-β-D-fucopyranosylstrophanthidin (1), 3-O-β-D-quinovopyranosylperiplogenin (2), and 3-Oβ-D-glucopyranosyl-(1f4)-R-L-rhamnopyranosylcannogenin (3), together with seven known cardenolides (4–10), were isolated from a cytotoxic ethanol extract of the whole dried plants of Saussurea stella. The structures of these compounds were established by spectroscopic and chemical methods. When the cytotoxicity of compounds 2–10 toward Bel-7402 human hepatoma cells and BGC-823 human gastric cancer cells was evaluated, all compounds showed IC50 values of
