CHALLENGE US. O R G A N I C
S P E C I A L T Y
I N T E R M E D I A T E S
P H O S P H I N E S
Achieve high regioselectivity at virtually any position on ring
Enable Stille, Suzuki, Heck, Negishi and Sonogashira reactions*
Provide functional groups of aldehydes, halides, boronic acids or other electrophiles
Use of aryl chlorides vs. bromides
Utilize direct lithiation, alpha lithiation, lithium-halogen exchange or directed orffto-metalation (DoM) protocols*
Increase catalyst turnover and efficiency producing higher yields
Me
Me'
'Me
.B(OH) 2 DMG=OMe, F, NH : OMe
"Regioselective lithiation of pyridine rings, Christopher J. Woltermann and James A. Schwindeman, PharmaChem;2002; November/December]
(7) pp 5 - 8.
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