Charge Delocalization and Enhanced Acidity in Tricationic

ARTICLE pubs.acs.org/JACS

Charge Delocalization and Enhanced Acidity in Tricationic Superelectrophiles Rajasekhar Reddy Naredla,† Chong Zheng,† Sten O. Nilsson Lill,‡ and Douglas A. Klumpp*,† † ‡

Department of Chemistry and Biochemistry, Northern Illinois University, DeKalb, Illinois 60115, United States Department of Chemistry, University of Gothenburg, SE-412 96 Gothenburg, Sweden

bS Supporting Information ABSTRACT: This Article presents the results from studies related to the chemistry of tricationic superelectrophiles. A series of triaryl methanols were ionized in Brønsted superacids, and the corresponding tricationic intermediates were formed. The trications are found to participate in two types of reactions; both are characteristic of highly charged organic cations. One set of reactions occurs through charge migration. A second set of reactions occurs through deprotonation of an unusually acidic site on the tricationic species. One of the tricationic intermediates has been directly observed by low temperature NMR spectroscopy. These highly charged ions and their reactions have also been studied using density functional theory calculations. As a result of charge migration, electron density at a carbocation site is found to increase with progression from monocationic to pentacationic structures.

’ INTRODUCTION During the mid-1970s, Olah proposed the concept of superelectrophilic activation.1 Several published studies had previously described the high reactivities of monocationic electrophiles in superacidic media. This suggested that the monocationic electrophiles were interacting with the acidic media to enhance their reactivities. Thus, protonation of a monocationic species such as the nitronium ion (1) could produce an ion with an increasing positive charge (2, eq 1). In the limiting cases, even dicationic species (3) are considered to be involved in the chemistry. While many examples of dicationic superelectrophiles have been described,2 few examples of tricationic species have been studied. Most tricationic and tetracation species are formed as resonance stabilized ions.3 Little is known about the reactivities of small organic ions bearing such a large amount of positive charge.4 In this Article, we describe studies in which a reactive carbocation site interacts with two adjacent cationic charges. Reactions of the tricationic species with arenes lead to products consistent with charge migration. Under some conditions, these reactive intermediates undergo cyclizations to produce novel heterocyclic ring systems. The tricationic intermediates are further studied by spectroscopic and theoretical methods.

’ RESULTS AND DISCUSSION Our studies began with an examination of the chemistry of triarylmethanols (4 8, 14, 15) by reaction in superacidic CF3SO3H (Table 1). The triarylmethanol substrates were r 2011 American Chemical Society

prepared readily from reactions of the appropriate ketones or esters with organolithium reagents. Two types of conversions were observed, depending on whether benzene was present in the mixture. In the presence of C6H6, alcohol 4 gives product 9 in 89% yield at 60 °C (entry 1). If the reaction was done at lower temperatures, then the starting material was recovered. Similar results were obtained with imidazole and benzimidazole-based substrates (5, 7, 8; entries 2, 4, 5). When the reaction was done with a substrate (6) bearing the 2-naphthyl substituent, nucleophilic attack occurred at the C-1 position of the naphthyl ring to give product 11 in good yield. The structure of compound 11 was established by 1H and 13C NMR spectra, mass spectrum analysis, and X-ray crystallography.5 In the absence of benzene, reactions of the triarylmethanols lead to cyclization products (entries 6 10). For example, compound 4 reacts in CF3SO3H at 60 °C to provide the pyrido[1,2a]indole derivative (16) in 81% yield. Benzimidazole derivatives 5, 6 also react to give cyclization products (17 and 18). In the reaction of 6, cyclization occurs regioselectively at the 1-position of the naphthyl ring to give product 18 (confirmed by X-ray crystal structure).5 The pyrido[1,2-a]indole derivatives 19 and 20 were formed by reactions of compounds 14 and 15, respectively. Product 20 is the only major product from 15, indicating a preference for cyclization at the pyridine ring. The vinyl-substituted derivative (21) does not undergo cyclization in CF3SO3H; however, a low yield of cyclization product (22) may be obtained from reaction in the stronger acid system CF3SO3H SbF5 (ca. 10:1; eq 2). These types of cyclizations involving N-heterocycles are not well-known, as the only other example was described by Received: May 26, 2011 Published: July 11, 2011 13169

dx.doi.org/10.1021/ja2046364 | J. Am. Chem. Soc. 2011, 133, 13169–13175

Journal of the American Chemical Society

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Table 1. Reactions of Heterocyclic Alcohols in CF3SO3H at 60 °C (with and without C6H6)

Posselt (involving cyclization between a 4-methoxyphenyl group and a pyridine or pyridinium ring).6 Nevertheless, our results indicate that novel heterocyclic ring systems are prepared by the superacid promoted cyclizations of the triarylmethanols.

When triarylmethanols 23 or 24 are reacted under similar conditions, the carbocations 25 and 26 are produced (Figure 1). However, with benzene, no Friedel Crafts products are formed from the monocation 25 or dication 26. With simple heating to 60 °C (no benzene), cyclization products are also not obtained.7 Compound 4 generates the tricationic intermediate 27 in heated superacid. Thus, trication 27 exhibits enhanced reactivity as compared to 25 and 26. When substrate 4 is reacted with substituted arenes, product formation (28 30) occurs with good regioselectivity. Reaction of compound 4 with toluene in CF3SO3H gives 28 as the major product, isolated in 72% yield. Gas chromatography analysis of the crude product mixture indicated a para,ortho/meta ratio of about 10:1. A competition experiment was also done with substrate 4 in a CF3SO3H-promoted reaction with toluene/benzene (1/1 ratio). Analysis of the product mixture

showed high selectivity for the toluene with kt/kb of about 30:1. Similar results are obtained from reactions of 4 with bromobenzene and 4-(3-phenylpropyl)pyridine. Products 29 and 30 are formed in good yields with high regioselectivities. In addition to arene nucleophiles, we also attempted to capture the electrophilic intermediate(s) with n-type nucleophiles, including carbon monoxide, fluoride, and water. Although carbon monoxide often reacts efficiently with carbocationic intermediates,8 no adducts of this nucleophile could be isolated in reactions with 4 in superacid. When compound 4 is reacted in CF3SO3H and KHF2 is added, then fluoride adduct 31 may be isolated in 51% yield (eq 3; compound 4 is also recovered). Interestingly, nucleophilic attack occurs at the methine carbon rather than at the ring carbon. A similar reaction of 4 with CF3SO3H, followed by water, leads to formation of the starting material 4, rather than functionalization at the remote position.

In our mechanistic studies, the intermediates and transition states were studied using density functional theory (DFT). 13170

dx.doi.org/10.1021/ja2046364 |J. Am. Chem. Soc. 2011, 133, 13169–13175

Journal of the American Chemical Society Geometries for these structures were initially optimized in the gas phase at the M06/6-31G(d) level of theory9 using Jaguar.10 Gibbs’ free energy corrections (ΔG) were calculated, and structures were verified to be minima or transition states by inspection of the number of imaginary frequencies. In a second step, singlepoint energies of the optimized structures were calculated using M06/cc-pVTZ(-f),11,12 giving a basis set correction term (ΔBS). In a final step, solvent phase geometry optimizations were done. Using a Poisson Boltzmann solver as implemented in Jaguar,13 electrostatic solvation effects from the surroundings were calculated using the SCRF method with CF3SO3H as a solvent (dielectric constant = 77.4, probe radius = 2.5985274).14 The free energy (ΔG) and basis set correction terms (ΔBS) were added to the solution phase energy. NMR chemical shifts were calculated using B3LYP/IGLO-II as implemented in Gaussian 03,15 17 on M06/6-31G(d) gas-phase optimized structures with benzene set to the experimental value of 127.7 ppm as the NMR reference. NBO charges were calculated using NBO 5.0 as implemented in Jaguar.18 To verify that the M06/6-31G(d) compounds were able to properly describe the σ- and π-complexes, tests were also performed using B3LYP-DCP/6-31+G(d,p), a dispersion-corrected DFT method,19,20 resulting in optimized structures similar to those with M06/6-31G(d).

Figure 1. Ionization products (25 27) and Friedel Craft reaction products 28 30.

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In considering the mechanisms of the reactions, we propose a mechanism involving formation of tricationic intermediates with highly delocalized carbocation centers and equilibria with a dicationic species from deprotonation. The alcohol substrates (4 8) react with benzene in the superacid, and nucleophilic attack occurs at the remote position on the aryl substituent group (Figure 2). Thus, compound 4 ionizes in superacid, and loss of water produces the tricationic superelectrophile 27. With formation of the carbocation 27, positive charge is highly delocalized into the adjacent phenyl ring. Nucleophilic attack occurs at the remote position on the phenyl group to give intermediate 32, when benzene is present in the reaction mixture. Several examples of charge migration and remote functionalization have previously been reported involving dicationic superelectrophiles.21 Product 31 is formed by fluoride attack at the methine carbon, suggesting that some positive charge remains at the methine center. This raises an obvious question: why would the n-type nucleophiles (fluoride and water) react at the methine carbon while πtype nucleophiles (benzene and substituted arenes) react at the remote para-position of the phenyl group? First, there is likely some degree of steric effects influencing the regiochemistry of nucleophilic attack. Nucleophilic attack at the methine carbon (by benzene) would form the highly congested tetraarylmethane. Second, formation of the π-complex may enhance charge separation (Figure 3). Formation of the toluene π-complex (33a), and subsequent Wheland intermediate or σ-complex (34a), effectively moves the positive charge away from the pyridinium rings. Density functional theory (DFT) calculations were done (vide infra) and showed the toluene ring bears +0.62 charge in the π-complex (33a) and +0.97 charge in the σ-complex (34a). In the case of toluene, steric effects in the π-complex may also be important in the high para selectivity.22 Although high positional selectivity is often due to a large energy barrier between the π-complex and σ-complex,23 this does not appear to be the case with 33a and 34a. DFT calculations have indicated that the π-complex resides in a very shallow potential energy well, as small perturbations in structure 33a easily lead to formation of the σ-complex 34a as found by DFT geometry optimizations. In the competition experiment, high substrate selectivity was observed (kt/kb ≈ 30:1). This value likely reflects the relative stabilities of the σ-complexes with benzene and toluene.23 When the π- and σ-complexes are examined, the σ-complex from toluene (34a) is 7.9 kcal mol 1 more stable than the π-complex from toluene (33a), while the σ-complex from benzene (34b) is only 4.6 kcal mol 1 more stable than its πcomplex with benzene (34a). In reactions of compound 6, products 11 and 18 were formed. While charge migration occurred into the napthyl ring system, it did not delocalize to the most remote position (across both rings). Ionization of the benzimidazole rings and the hydroxy group leads to trication 35a (eq 4). Formation of product 11

Figure 2. Proposed mechanism for the reactions of trication 27, leading to product 9. 13171



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Figure 3. Relative energies of Wheland- and π-complexes with toluene (33a, 34a) and benzene (M06/6-31G*-optimized structures, 33b, 34b).

Table 2. Observed 13C NMR Data from Isoelectronic Carbocations 25 27 and Calculated 13C NMR Data for 25 27 and 36,37a

a

(a) Spectrum taken at

60 °C. (b) Spectrum taken at 0 °C.

occurs by nucleophilic attack at the 1-position of the naphthyl group. This implies a greater contribution from resonance structure 35b, instead of structure 35c (the structure with greater charge separation).

To gain further insight into these reactions, low temperature C NMR experiments were done. Compound 4 was ionized in FSO3H SbF5 SO2ClF at 60 °C, and the observed spectrum is consistent with the formation of the tricationic species 27 (Table 2). For comparison, the DFT calculated spectrum of trication 27 is in reasonably good agreement with the results from solution (for complete assignments of 13C signals, see the 13

Supporting Information). It is notable that the para and ortho carbons are significantly deshielded. This is consistent with the charge delocalization driven by charge charge repulsive effects. The dicationic ion 26 and the trityl cation (25)24 were also studied in solution by low temperature 13C NMR, with comparison to calculated spectra. Interestingly, the chemical shift at the methine carbon moves progressively downfield from the monocationic trityl cation (25), to the dication (26), and to the trication (27). This is an indication that charge delocalization becomes enhanced with increasing charge. The tetra- and pentacationic structures (36, 37) were also calculated, and the results show further deshielding of the para-position and shielding of the methine carbon. While the trityl cation has a calculated chemical shift of δ 144 at the para position of the phenyl ring, the pentacation 37 has a calculated chemical shift of δ 231 at the para position of the phenyl ring. As a measure of charge delocalization in these systems, natural bond order (NBO) charges, bond lengths, and dihedral angles were analyzed from the calculated structures. In a series of related 13172



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Table 3. Calculated Properties of Isoelectronic Ions 25 27 and 36,37

NBO charge dihedral angle, δ

C C bond length (methine-ipso), Å

0.15

33.2°

1.441

0.10

31.1°

1.429

+0.12

0.00

24.0°

1.402

0.01 0.14

+0.10 +0.20

19.5° 11.2°

1.394 1.391

structure

charge

C-methine

25

1+

+0.24

26

2+

+0.15

27

3+

36 37

4+ 5+

C-para

Figure 4. Calculated structures related to the cyclization of trication 27.

structures, 13C NMR chemical shifts may be roughly correlated to charge densities.25 Down field chemical shifts (or deshielding) often correspond to electron-deficient carbon atoms.25 Within the isoelectronic series from the trityl cation (25) to the pentacation (37), experimental and calculated NMR spectral data suggest that the carbocationic center moves progressively from the methine carbon to the para position of the phenyl ring. The calculated NBO charges also show this trend (Table 3). Remarkably, there is almost a complete transfer of positive charge from the methine carbon to the para-carbon. The methine carbon

carries a +0.24 NBO charge in the trityl cation (25) and a 0.14 NBO charge in the pentacation (37), while the para-carbon carries a 0.15 NBO charge in 25 and a +0.20 NBO charge in 37. As the positive charge is moved to the para position, there is also increasing double bond character between the methine carbon and the phenyl ring. This is apparent from the decreasing bond dihedral angle (δ) and C C bond length as charge is added to the system. Thus, the trityl cation 25 has a dihedral angle of 33.2° and C C bond length of 1.441 Å, while the pentacation 37 has a dihedral bond angle of 11.2° and C C bond length of 1.391 Å. 13173


Journal of the American Chemical Society The dihedral angle and NBO charge are strongly correlated to the overall charge on the cationic structure. Increasing charge leads to progressively greater positive charge at the para-carbon, while simultaneously increasing electron density at the methine carbon (evident from the negative NBO charges). Although it might be expected that a carbocationic center would exhibit increasing positive charge as neighboring groups become more electron deficient, the opposite occurs in this case. The increasing charge of the N-heterocycles leads to charge migration across the phenyl ring to the remote para position (maximizing the charge charge separation). As described in Table 1, compound 4 reacts in CF3SO3H to give the pyrido[1,2-a]indole derivative (16) in the absence of an arene nucleophile. Because ionization of 4 should provide trication 27, theoretical calculations were also done to study the cyclization of the tricationic species 27 (Figure 4). Calculations suggest that direct cyclization of the trication 27 is unlikely, as the transition state 38 leading to 39 is estimated to be 41 kcal/mol above 27. The cyclized trication 39 itself is 38 kcal/mol higher in energy. A lower energy pathway was found involving initial deprotonation at the pyridinium ring, proceeding through two minima (40 and 41) and giving dication 42 in a slightly exothermic step. Cyclization then occurs with a barrier of 9.8 kcal/mol (43), and it gives stabilized species 44 and 45. Upon basic workup, cation 45 provides the observed product 16. Although triflate normally would not be expected to deprotonate a pyridinium ring, the high charge density of the trication 27 must lead to enhanced acidity of the pyridinium hydrogen. Previous studies have shown superelectrophiles to possess highly acidic protons.26 With trication 27, the carbocationic site cannot readily lead to a deprotonation equilibrium, so instead the pyridinium ring undergoes deprotonation. Ionization of compound 4 in FSO3H SbF5 SO2ClF gives NMR spectral data that differs somewhat from the calculated spectrum for trication 27. While experimental NMR spectra often differ slightly from the calculated spectra, the present case may be the result of an equilibrium between trication 27 and the dication 42. Rapid proton transfer should average the spectral data from 27 and 42, and this would account for the differences between the calculated and experimental spectra for trication 27. As shown in Table 2, the experimental data for the compound 4 ionization product, presumably trication 27, showed a methine resonance at δ 176.8 and para-carbon at δ 169.4. The calculated spectrum for 27 has a methine resonance at δ 176.0 and paracarbon at δ 178.2. When dication 42 was studied computationally, the calculated spectrum has a methine resonance at δ 179.1 and para-carbon at δ 161.6 (for a full list of peaks, see the Supporting Information). If a numerical average is made from the calculated chemical shift values of trication 27 and dication 42, then an averaged spectrum should have methine resonance at δ 177.6 and para-carbon at δ 169.9. These averaged values are very close to the experimentally determined values from ionization of 4 in magic acid. Moreover, the calculated energies of 27 and 42 are within 0.5 kcal/mol, suggesting a significant concencentration of these two species from the low temperature ionization. This raises an obvious question: could all of the chemistry simply involve equilibria between dications? This question was examined computationally by considering the step in which the alcohol ionizes to the carbocation. Assuming the alcohol group must be protonated for ionization, this means the dicationic intermediate 46 would of necessity be involved in the chemistry. However, calculations indicate that 46 is about 35 kcal/mol less

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Figure 5. Cyclization of trication 46 to compounds 20 and 51.

stable than the dication in which both pyridyl rings are protonated (47). This strongly suggests the formation of the tricationic oxonium ion 48, leading to the proposed tricationic superelectrophile 27.

As described in Table 1, compound 15 reacts in superacid to give the pyrido[1,2-a]indole 20. This product is somewhat surprising, as a dicationic cyclization might be expected to cyclize into the benzothiazole ring. Assuming ionization of 15 leads to the trication 49, deprotonation could lead to either 50 or 51, but only dication 50 should lead to product 20 (Figure 5). However, the pKa data for the parent heterocycles suggest that the benzothiazole ring should be more acidic (pKa for pyridine 5.2; pKa for benzothiazole 1.2).27 This apparent inconsistency may be explained by considering the stabilities of the intermediates 52 and 53. DFT calculations have shown that cyclization through the pyridine ring leads to an intermediate (52) that is 4.6 kcal/mol more stable than a similar intermediate with benzothiazole cyclization (53). Likewise, product 20 is almost 4 kcal/mol more stable than its isomer 54. 13174



’ CONCLUSIONS We have studied the superacid-promoted reactions of a series of triarylmethanols, which generate tricationic intermediates. As compared to analogous mono- and dicationic species, the tricationic intermediates exhibit new reactions resulting from the effects of the closely oriented positive charges. These effects include the tendency for cationic charge to “migrate” across a phenyl ring and the tendency for neighboring protons to exhibit very high acidities. The migration of charge across organic structures is important in material science applications and in the design of organic-based electronics. Our results show that densely charged structures may have high charge mobilities. As a consequence, these tricationic superelectrophiles react with arene nucleophiles at a remote site. Without a nucleophilic reactant, cyclizations occur to provide novel N-heterocyclic products. The functionalized heterocycles are produced in good to excellent yields. Computational studies indicate that this chemistry arises from the deprotonation of an unusually acidic pyridinium ring. ’ ASSOCIATED CONTENT

bS

Supporting Information. Detailed experimental procedures, characterization data, 1H and 13C NMR spectra for new compounds, 13C NMR spectra for ions 26 and 27, computational methods and results, and crystallographic data for compounds 11 and 18. This material is available free of charge via the Internet at http://pubs.acs.org.

’ AUTHOR INFORMATION Corresponding Author

[email protected]

’ ACKNOWLEDGMENT We gratefully acknowledge the support of the National Science Foundation (CHE-0749907 and CRIF MU-0840504) and the NIH-National Institute of General Medical Sciences (GM085736-01A1). S.O.N.L. gratefully acknowledges the financial support from the Åke Wiberg Foundation. ’ REFERENCES (1) Olah, G. A.; Germain, A.; Lin, H. C.; Forsyth, D. J. Am. Chem. Soc. 1975, 97, 2928–2929. (2) Olah, G. A.; Klumpp, D. A. Superelectrophiles and Their Chemistry; Wiley: New York, 2008. (3) (a) Prakash, G. K. S.; Rawdah, T. N.; Olah, G. A. Angew. Chem., Int. Ed. Engl. 1983, 22, 390–401. (b) Ito, S.; Morita, N.; Asao, T. Bull. Chem. Soc. Jpn. 2000, 73, 1865–1874. (c) Head, N. J.; Prakash, G. K. S.; Bashir-Hashemi, A.; Olah, G. A. J. Am. Chem. Soc. 1995, 117, 12005–12006. (d) Rathore, R.; Burns, C. L.; Green, I. A. J. Org. Chem. 2004, 69, 1524–1530. (e) Reddy, V. P.; Rasul, G.; Prakash, G. K. S.; Olah, G. A. J. Org. Chem. 2003, 68, 3507–3510. (f) See also: Pagni, R. M. Tetrahedron 1984, 49, 4161–4215. (4) For recent examples of reactive tricationic species, see: (a) Ohwada, T.; Yamagata, N.; Shudo, K. J. Am. Chem. Soc. 1991, 113, 1364–1373. (b) Kurouchi, H.; Sugimoto, H.; Otani, Y.; Ohwada, T. J. Am. Chem. Soc. 2010, 132, 807–815. (c) Zhang, Y.; Sheets, M. R.; Raja, E. K.; Boblak, K. J.; Klumpp, D. A. J. Am. Chem. Soc. 2011, 133, 8467–8469. (5) Crystallographic data are found in the Supporting Information.

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(6) (a) Posselt, K. Arzneim. Forsch. 1978, 28, 1056–1065. (b) See also: Alarcon, H. A. R.; Soldatenkov, A. T.; Soldatova, S. A.; Samalyoa, A. I.; Obando, H. U.; Prostakov, N. S. Khim. Geterotsikl. Soedin. 1993, 1233–1238. (7) Decomposition products are obtained. (8) Sommer, J.; Bukala, J. Acc. Chem. Res. 1993, 26, 370–376. (9) Zhao, Y.; Truhlar, D. Theor. Chem. Acc. 2008, 120, 215–241. (10) Jaguar, version 7.7; Schrodinger, LLC: New York, 2010. (11) Dunning, T. H. J. Chem. Phys. 1989, 90, 1007–1023. (12) Woon, D. E.; Dunning, T. H. J. Chem. Phys. 1993, 98, 1358–1371. (13) Marten, B.; Kim, K.; Cortis, C.; Friesner, R. A.; Murphy, R. B.; Ringnalda, M. N.; Sitkoff, D.; Honig, B. J. Phys. Chem. 1996, 100, 11775–11788. (14) Lira, A. L.; Zolotukhin, M.; Fomina, L.; Fomine, S. J. Phys. Chem. A 2007, 111, 13606–13610. (15) Frisch, M. J. T.; et al. Gaussian 03, revision D.02; Gaussian, Inc.: Wallingford, CT, 2004. (16) Stephens, P. J.; Devlin, F. J.; Chabalowski, C. F.; Frisch, M. J. J. Phys. Chem. 1994, 98, 11623–11627. (17) Kutzelnigg, W.; Fleischer, U.; Schindler, M. In NMR, Basic Principles and Progress; Diehl, P., Fluck, E., G€unther, H., Kosfield, R., Seelig, J., Eds.; Springer-Verlag: Berlin, 1990; Vol. 23, pp 165 262. (18) Glendening, E. D.; Badenhoop, J. K.; Reed, A. E.; Carpenter, J. E.; Bohmann, J. A.; Morales, C. M.; Weinhold, F. NBO 5.0; Theoretical Chemistry Institute, University of Wisconsin, Madison, WI, 2001; http://www.chem.wisc.edu/∼nbo5. (19) Mackie, I. D.; DiLabio, G. A. J. Phys. Chem. A 2008, 112, 10968–10976. (20) Nilsson Lill, S. O. J. Mol. Graphics Modell. 2010, 29, 178–187. (21) (a) Ohwada, T.; Okabe, K.; Ohta, T.; Shudo, K. Tetrahedron 1990, 46, 7539–7555. (b) Shudo, K.; Ohta, T.; Okamoto, T. J. Am. Chem. Soc. 1981, 103, 645–653. (c) Nakamura, S.; Sugimoto, H.; Ohwada, T. J. Am. Chem. Soc. 2007, 129, 1724–1732. (d) O’Connor, M. J.; Boblak, K. N.; Topinka, M. J.; Kindelin, P. J.; Briski, J. M.; Zheng, C.; Klumpp, D. A. J. Am. Chem. Soc. 2010, 132, 3266–3267. (22) Nelson, K. L.; Brown, H. C. J. Am. Chem. Soc. 1951, 73, 5605–5607. (23) Olah, G. A. Acc. Chem. Res. 1971, 4, 240–248. (24) Abarca, B.; Asensios, G.; Ballesteros, R.; Luna, C. Tetrahedron Lett. 1986, 27, 5657–5660. (25) (a) Forsyth, D. A.; Sandel, B. B. J. Org. Chem. 1980, 45, 2391–2394. (b) Forsyth, D. A.; Spear, R. J.; Olah, G. A. J. Am. Chem. Soc. 1976, 98, 2512–2518. (26) (a) Nenajdenko, V. G.; Shevchenko, N. E.; Balenkova, E. S. Chem. Rev. 2003, 103, 229–282. (b) Olah, G. A.; Grant, J. L.; Spear, R. J.; Bollinger, J. M.; Serianz, A.; Sipos, G. J. Am. Chem. Soc. 1976, 98, 2501. (c) Larsen, J. W.; Bouis, P. A. J. Am. Chem. Soc. 1975, 97, 6094–6102. (d) Olah, G. A.; Calin, M. J. Am. Chem. Soc. 1968, 90, 4672–4675. (e) Olah, G. A.; Reddy, V. P.; Rasul, G.; Prakash, G. K. S. J. Am. Chem. Soc. 1999, 121, 9994–9998. (27) (a) Perrin, D. D. Dissociation Constants of Organic Bases in Aqueous Solution; Butterworths: London; 1965. (b) Eicher, T.; Hauptmann, S. The Chemistry of Heterocycles; Wiley-VHC: Weinheim, 2003.

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Charge Delocalization and Enhanced Acidity in Tricationic

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