J . Med. Chem. 1995,38, 1052
1052
Additions and Corrections 1994, Volume 37
John A. Mountzouris, Jeh-Jeng Wang, David Thurston, and Laurence H. Hurley": Comparison of a DSB-120 DNA Interstrand Cross-Linked Adduct with the Corresponding Bis-tomaymycin Adduct: An Example of a Successful Template-Directed Approach to Drug Design Based upon the Monoalkylating Compound Tomaymycin. Page 3138. The stereochemistry at the C-11position (S) was inadvertently shown as ( R ) in Figure 9. The correct figure appears below. Unusual Conformation: Broad 8H2 proton resonance, non-C2' endo sugar geometry, very weak 7CH1'-81H8 NOE
5'
1
2
3
5
4
6
*
7
8
9 10
CICGATC~CG /
II
8 ;",e "
0
Greater solvent accessibility
Shallow immersion in minor groove
HN
GCIIICTAGC Ic 1
0
9
8
7
6
5
4
3
2
1
5'
Figure 9. Summary of unusual properties of the DSB-120 5'CGA'" cross-linked adduct. JM941188Y
0022-2623/95/1838-1052$09.00/0 0 1995 American Chemical Society
