Apr 17, 2017 - missing an oxygen atom to the immediate left of the stereogenic center. The upper left structure should feature a. âpropylâ ether, not an âethylâ.
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Oct 19, 2016 - These compounds demonstrate subnanomolar HIV-1 activity, have a ...... Distinctive Clinical, Pathological, and Mitochondrial Abnormalities ...
The pharmacokinetic properties of tenofovir (TFV) and other charged nucleoside analogues are dramatically improved upon conjugation to a lipid prodrug.
Oct 19, 2016 - In continuation of that work, we have synthesized next-generation conjugates with reduced cytotoxicity that retain potent antiviral activity against ...
Jul 13, 2016 - adefovir, and other antiviral nucleosides that demonstrate potent antiviral activity but poor bioavailability. Using TFV as a model substrate, we ...
Oct 19, 2016 - jm6b01292_si_002.csv (0.68 kB). Citing Articles; Related Content. Citation data is made available by participants in Crossref's Cited-by Linking service. For a more comprehensive list of citations to this article, users are encouraged
Apr 17, 2017 - Abstract: The nonselective glucocorticoid receptor (GR) antagonist mifepristone has been approved in the U.S. for the treatment of selected patients with Cushing's syndrome. While this drug is highly effective, lack of selectivity for
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Addition/Correction pubs.acs.org/jmc
Correction to Reduction Sensitive Lipid Conjugates of Tenofovir: Synthesis, Stability, and Antiviral Activity Kyle E. Giesler,* Jose Marengo, and Dennis C. Liotta* Journal of Medicinal Chemistry 2016, 59, 7097−7110. DOI: 10.1021/acs.jmedchem.6b00428 Page 7097. In the abstract graphic, all of the structures are missing an oxygen atom to the immediate left of the stereogenic center. The upper left structure should feature a “propyl” ether, not an “ethyl”. The bottom structure should have an aliphatic chain length of 16 carbon atoms immediately left of the disulfide, not 13. The correct abstract graphic is shown below:
Page 7098. In Figure 1, the structure of compound 1 (CMX157) should feature a “propyl” ether, not an “ethyl” ether. The correct Figure 1 is shown below:
Page 7098: In Figure 2, the structure is missing an oxygen atom to the immediate left of the stereogenic center. The correct Figure 2 is shown below:
