OT IP®if MMF mm^Π®1 g®MMÏ ilEWi DMF a useful solvent for certain reactions of sulfur and sulfur compounds. When used in specific reactions of sulfur and sulfur compounds, DMF gives: • fewer side reactions • good yields • mild conditions
Economy in production-scale use
Only suitable solvent DMF was shown to be the only suitable solvent for the preparation of sodium cyanodithioformate [Ber. 88,1771 (1955)]. The addition reaction was so rapid that side reactions were minimized. The product was stabilized by complexing with three molecules of DMF.
S
NaCN + CS 2
II
Ν α - S - C - C N · 3DMF
reflux
Discover the opportunities for improving products and processes with Du Pont DMF at 220 per lb.
9 0 % Yield
Willgerodt-Kindler reaction A variation of the Willgerodt-Kindler reaction gives thioamides in good yield at room temperature and atmos pheric pressure when run in DMF [Angew. Chem. Int. Ed. Engl. 3, 705(1964)].
DMF (dimethylformamide) is the least expensive of the "super" (highly dipolar aprotic) solvents. In addition, easy recovery, high conversions and faster reaction rates result in low use-costs. Versatility in chemical processes DMF is used in the manufacture of a wide range of prod ucts, involving many classes of organic reactions, often with existing equipment. Efficiency through high yields and pure products Higher conversions and faster reaction rates are often possible with DMF, resulting in higher product yields. Product purity results from reduced by-product contam ination. Easy recovery DMF can easily be recovered by simple distillation at atmospheric or reduced pressure. High recoveries (up to 99%) not only reduce production costs, but also improve pollution control. Du Pont's new DMF Recovery and Puri fication Bulletin provides basic data on methods and equipment for recovery of DMF in production operations. Mail the coupon for more information on Du Pont DMF.
- c=
CH 2
o
DMF
7 5 % Yield
Dehydrogenation of dihydrofuran using DMF and sulfur The dehydrogenation of dihydrofuran ring was best ac complished by using sulfur in DMF. 3-Phenyl-2,5-dihydrofuran dehydrogenated smoothly when refluxed in DMF containing 2-3% sulfur [J. Am. Chem. Soc. 80, 364 (1958)].
Du Pont Company Room 7946 Wilmington, Delaware 19898 Please send Π DMF Bulletin Π DMF Recovery and Purification Bulletin Name TitleCompanyStreet
ceH5
D
DMF I55°C
CeH,
-State-
City Zip
_ Telephone-
8 5 % Yield
mm DMF «EG υ S PAT Off
