Exploration of the Pharmacophore of 3-Alkyl-5

Fre´de´ric Ooms, Johan Wouters, Olivier Oscari,. Thierry Happaerts, Ge´raldine Bouchard, Pierre-. Alain Carrupt, Bernard Testa, Didier M. Lam-...
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J. Med. Chem. 2002, 45, 4799

Additions and Corrections 2002, Volume 45 Fre´ de´ ric Ooms, Johan Wouters, Olivier Oscari, Thierry Happaerts, Ge´ raldine Bouchard, PierreAlain Carrupt, Bernard Testa, Didier M. Lambert*: Exploration of the Pharmacophore of 3-Alkyl5-arylimidazolidinediones as New CB1 Cannabinoid Receptor Ligands and Potential Antagonists: Synthesis, Lipophilicity, Affinity, and Molecular Modeling. Page 1750. Scheme 1 is incorrect. The correct Scheme 1 appears below. Scheme 1a

a Reagents: (a) KCNO, water, 80 °C, 30 min; (b) HCl, ethanol, reflux 2 h; (c) RCl, K2CO3, DMF, room temperature overnight.

JM020995R 10.1021/jm020995r Published on Web 09/14/2002

4799