Downloaded by 80.82.77.83 on December 26, 2017 | http://pubs.acs.org Publication Date: November 7, 2008 | doi: 10.1021/bk-2008-0992.pr001
Preface Controlled drug delivery systems are prepared from synthetic or natural materials and combined with a drug or an active ingredient allowing its release in a predetermined fashion. The release can be constant, cyclic, or triggered by changes in physiological environment or an external event. The development o f novel drug delivery systems that are capable o f controlling the release o f drugs to specific sites in the body has attracted considerable attention. Early biomaterials were selected primarily for their desirable physical properties and not for delivery o f active ingredients in biological systems. In recent years, however, new systems have been prepared from naturally occurring materials that are biocompatible and resistant to enzymatic and chemical attack in the in vivo environment. Today, microencapsulation and controlled-release technologies are finding broad application not only in the pharmaceutical industry but also for transplantation and regeneration medicine, for example, scaffoldbased drug delivery for tissue engineering. The advantages o f using controlled delivery systems in the aforementioned applications is primarily the maintenance o f drug levels within defined ranges, in a localized manner while maintaining overall biocompatibility. Possible disadvantages, however, include the high cost o f controlled-release systems, potential toxicity, or non-biocompatibility o f the materials used. This book is targeted toward scientists and engineers in industry, government, and academia who are interested in the development o f novel drug delivery systems and regeneration technologies from natural materials. A n understanding o f physicochemical changes and how such changes affect the performance o f the drug or active ingredient w i l l allow researchers to develop formulations with optimized performance. This volume was developed from a symposium presented at the 2005 International Chemical Congress o f Pacific Basin Societies sponsored by the American Chemical Society Division o f Macromolecular Chemistry in Honolulu, Hawaii, December 15-20, 2005. The editors attribute the success o f the symposium to the selection o f speakers who are recognized experts from both industry and academia. T o those experts who were missed we offer our apologies. We thank the speakers for their
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Parris et al.; New Delivery Systems for Controlled Drug Release from Naturally Occurring Materials ACS Symposium Series; American Chemical Society: Washington, DC, 2008.
excellent presentations and the timely preparation of their chapters. We also thank the reviewers for their incisive and constructive criticism.
Nicholas Parris
Downloaded by 80.82.77.83 on December 26, 2017 | http://pubs.acs.org Publication Date: November 7, 2008 | doi: 10.1021/bk-2008-0992.pr001
Eastern Regional Research Center Agricultural Research Service U.S. Department of Agriculture 600 East Mermaid Lane Wyndmoor Lane, P A 19038
[email protected] LinShu L i u Eastern Regional Research Center Agricultural Research Service U.S. Department of Agriculture 600 East Mermaid Lane Wyndmoor Lane, P A 19038
[email protected] Cunxian Song Institute of Biomedical Engineering Chinese Academy of Medical Sciences Tianjin 300192 People's Republic of China
[email protected] V . Prasad Shastri Department of Biomedical Engineering Vanderbilt University 5824 Stevenson Center Nashville, T N 37235
[email protected] xii
Parris et al.; New Delivery Systems for Controlled Drug Release from Naturally Occurring Materials ACS Symposium Series; American Chemical Society: Washington, DC, 2008.
Downloaded by 80.82.77.83 on December 26, 2017 | http://pubs.acs.org Publication Date: November 7, 2008 | doi: 10.1021/bk-2008-0992.pr001
New Delivery Systems for Controlled Drug Release from Naturally Occurring Materials
Parris et al.; New Delivery Systems for Controlled Drug Release from Naturally Occurring Materials ACS Symposium Series; American Chemical Society: Washington, DC, 2008.
