Article pubs.acs.org/OPRD
Rapid Electrochemical Deprotection of the Isonicotinyloxycarbonyl Group from Carbonates and Thiocarbonates in a Microfluidic Reactor Kenta Arai and Thomas Wirth* School of Chemistry, Cardiff University, Park Place, Cardiff CF10 3AT, U.K. S Supporting Information *
ABSTRACT: Electroreductive deprotection of the isonicotinyloxycarbonyl (iNoc) group from hydroxy, thiol, and amino groups was carried out in an electrochemical microreactor. The small distance of the platinum electrodes in the microreactor enables a rapid electrochemical redox reaction without added electrolytes. As a result, the electrochemical deprotection of O- and S-iNoc aromatic substrates was achieved in short reaction times (
