Book Review pubs.acs.org/jnp
Review of Handbook of Porphyrin Science with Applications to Chemistry, Physics, Material Sciences, Engineering, Biology and Medicine, Toward Diagnostics and Treatment of Cancer In Chapter 193, “Molecular Targeted Photodynamic Therapy for Cancer”, the authors discuss in vitro and in vivo mouse models to demonstrate how photodynamic therapy via photosensitizers and precise light delivery has a highly selective therapeutic potential in the field of oncology. This chapter reviews the conventional use of phototherapy and provides the modern scientific foundation to show its future therapeutic value. Chapter 194, “Photobiology and Photochemistry Hand-inHand in Targeted Anti-tumoral Therapies”, provides a detailed review of the development and optimization of phototherapy to specifically target cancer cells in order to achieve better selectivity and minimization of side effects. In addition, the authors discuss the strategies of incorporation of photosensitizers into nanocarriers such as nanoparticles and nanovesicles to selectively target cancer cells. This chapter provides in-depth information about the advances in photosensitizers design and how to target it selectively at the required site. In summary, this book thoroughly reviews recent advances in photodynamic therapy to diagnose and treat cancer. Although phototherapy has been used to treat a myriad of diseases such as psoriasis, the field is broadening as more sophisticated instruments to illuminate and activate the photosystem in living cells and tissues become more affordable and readily available. Thus, the advancement of photodynamic therapy especially in cancer biology is due to the collective efforts of clinicians, biologists, engineers, chemists, and physicists. This volume shows their collective role in the understanding of the subject as well as raises the hope that in the near future photodynamic therapy will cure cancers. I find these books highly useful to learn and understand the potential role of porphyrins in biomedical and pharmaceutical sciences. I strongly believe that this series is highly useful for scientists who are working in above areas and doing advance cutting-edge research in academia as well as in drug industries. Moreover, students of pharmacology, pharmacognosy, medicinal chemistry, and other allied areas will get immense benefit and understanding for those wanting to build their careers in porphyrin sciences.
Handbook of Porphyrin Science with Applications to Chemistry, Physics, Material Sciences, Engineering, Biology and Medicine, Toward Diagnostics and Treatment of Cancer., Volume 39. Edited by Karl M. Kadish (University of Houston, USA), Kevin M. Smith (Louisiana State University, USA), and Roger Guilard (Université De Bourgogne, France). World Scientific Publishing Co. Pte. Ltd., Singapore. 2016. Hardcover, pp. $1850.00 (set). ISBN 978-981-3140-82-0. he first series of Handbook of Porphyrin Sciences published in 2010 was dedicated to applications of porphyrins to chemistry, physics, material sciences, engineering biology, and medicine. The subject of this review, Handbook of Porphyrin Science with Applications to Chemistry, Physics, Material Sciences, Engineering, Biology and Medicine, Towards Diagnostics and Treatment of Cancer, Volume 39, is one volume of a four-book series. Volume 39 of the Handbook of Porphyrin Science, “Towards diagnostic and Treatment of Cancer”, is composed of five elaborated chapters: Chapter 190 to Chapter 194. The overall theme of this volume is to identify and to optimize biological pigments, such as porphyrins, as diagnostic and treatment tools in the managements of cancer. This book focuses on the better utilization of photodynamic therapy in the selective targeting of a variety of tumors by preventing the side effects and salvaging the normal body tissues from unwanted damage. In Chapter 190, “Phthalocyanines: From Dyes to Photosensitizers in Diagnostic and Treatment of Cancer, Spectroscopy and Raman Imaging Studies of Phthalocyanines in Human Breast Tissues”, the authors review the spectroscopic multimodal approach of cancer detection. More specifically, they show how Raman spectroscopy and photosensitizers can be exploited to better detect cancers and to differentiate between normal and cancer cells to selectively target cancer cells. Chapter 191, “Covalent and Non-Covalent Porphyrin-DNA Conjugates”, provides an in-depth review about the structural and functional aspects of porphyrin−DNA conjugates. Herein, the authors discuss ways to modify DNA using biological pigments such as porphyrin, which basically render DNA molecules more vulnerable to targeting during cancer treatment. Chapter 192, “When Polymers See the Light, Applications in Photodynamic Therapy and Photodiagnosis”, reviews the recent advances to target cancer cells using advanced biochemical technology such as nanoparticles. This chapter thoroughly reviews the uses of photodynamic therapy and photodiagnostic tools to better target cancer cells via polymer interface technology. The overall emphasis of the chapter is how to concentrate the photocompounds in the cancer cells using polymer and nanotechnology, thus making cells easy to identify and target.
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© 2017 American Chemical Society and American Society of Pharmacognosy
Mohammad Tauseef
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Chicago State University College of Pharmacy, Chicago, Illinois, United States
AUTHOR INFORMATION
ORCID
Mohammad Tauseef: 0000-0001-5317-4379 Notes
The author declares no competing financial interest.
Published: July 24, 2017 2389
DOI: 10.1021/acs.jnatprod.7b00516 J. Nat. Prod. 2017, 80, 2389−2389
