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Urinary Metabolites of Polycyclic Aromatic Hydrocarbons and the Association with Lipid Peroxidation: A BiomarkerBased Study between Los Angeles and Beijing Yan Lin, Xinghua Qiu, Nu Yu, Qiaoyun Yang, Jesus Araujo, and Yifang Zhu Environ. Sci. Technol., Just Accepted Manuscript • DOI: 10.1021/acs.est.5b04629 • Publication Date (Web): 25 Feb 2016 Downloaded from http://pubs.acs.org on February 25, 2016
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Environmental Science & Technology
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Urinary Metabolites of Polycyclic Aromatic Hydrocarbons
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and the Association with Lipid Peroxidation: A
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Biomarker-Based Study between Los Angeles and Beijing
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Yan Lin,1,2 Xinghua Qiu,2* Nu Yu1, Qiaoyun Yang2, Jesus Araujo3 and Yifang Zhu1*
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Department of Environmental Health Sciences, Jonathan and Karin Fielding
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School of Public Health, University of California, Los Angeles, Los Angeles,
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California 90095, United States
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State Key Joint Laboratory for Environmental Simulation and Pollution Control,
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College of Environmental Sciences and Engineering, and Center for Environment
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and Health, Peking University, Beijing 100871, P. R. China
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Division of Cardiology, Department of Medicine, School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, United States
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Submitted to Environmental Science and Technology for publication
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*
Corresponding Authors: Yifang Zhu:
[email protected] Xinghua Qiu:
[email protected] 18 19 20
Word count:
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Abstract: 188
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Text:
(including abstract, text, 1 table and 3 figures)
ACS Paragon Plus Environment
Environmental Science & Technology
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Beijing
(subjects)
(subjects)
Los Angeles
140 (subjects) 120 0.4 100
MDA 80
1-OH-PYR
0.2
60 40 0.0 Jun 7
Jun 13 Jun 16 Jun 29
Jul 9
Jul 19
Jul 30 Aug 16 Oct 11 Oct 19 Oct 25
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160
TOC
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Los Angeles
Urinary Conc. of MDA (µg g creatinine)
0.6
-1
Urinary Conc. of 1-OH-PYR (µg g creatinine)
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Environmental Science & Technology
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ABSTRACT
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Air pollution is among the top threats to human health in China. As air toxicants,
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polycyclic aromatic hydrocarbons (PAHs) could bring significant risks to
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population; however, the exposure to PAHs in China and its health impact are not
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fully understood. In 2012, a summer exchange program allowed 10 students
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travel from Los Angeles to Beijing and stay there for 10 weeks. Based on the
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program, this study investigated the difference in urinary concentration of 12
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hydroxylated-PAHs (Σ12OH-PAHs) and malondialdehyde (MDA) between the
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two cities. The median concentration of Σ12OH-PAHs in Beijing (14.1 µg g-1
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creatinine) was significantly higher than that in Los Angeles (5.78 µg g-1
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creatinine), indicating a higher exposure in Beijing. The ratios of homogenous
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OH-PAHs (e.g. 1-/2-OH-NAP) changed significantly between the two cities
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(p
