Article pubs.acs.org/accounts
Vitamin B12: A Tunable, Long Wavelength, Light-Responsive Platform for Launching Therapeutic Agents Thomas A. Shell*,† and David S. Lawrence*,‡ †
Department of Chemistry, Saint Anselm College, 100 Saint Anselm Drive, Manchester, New Hampshire 03102, United States Department of Chemistry, Division of Chemical Biology, and the Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States
‡
CONSPECTUS: Light-responsive agents offer the promise of targeted therapy, whose benefits include (i) prolonged action at the target site, (ii) overall reduced systemic dosage, (iii) reduced adverse effects, and (iv) localized delivery of multiple agents. Although photoactivated prodrugs have been reported, these species generally require short wavelengths (
