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Ecotoxicology and Human Environmental Health
Fine particle constituents and mortality: a time-series study in Beijing, China Chen Chen, Dandan Xu, Mike Z. He, Yanwen Wang, Zonghao Du, Yanju Du, Yan Qian, Dongsheng Ji, and Tiantian Li Environ. Sci. Technol., Just Accepted Manuscript • DOI: 10.1021/acs.est.8b00424 • Publication Date (Web): 31 Aug 2018 Downloaded from http://pubs.acs.org on August 31, 2018
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Environmental Science & Technology
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Fine particle constituents and mortality: a time-series study in Beijing, China
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Chen Chena, Dandan Xua, Mike Z. Heb,Yanwen Wanga, Zonghao Dua, Yanju Dua, Yan
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Qianc, Dongsheng Jid, Tiantian Lia,*
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a
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Environmental Health, Chinese Center for Disease Control and Prevention, Beijing,
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100021, China
Department of Environmental Health Risk Assessment, National Institute of
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b
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School of Public Health, New York 10032, United States
Department of Environmental Health Sciences, Columbia University Mailman
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c
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Research Academy of Environmental Sciences, Beijing 100012, China
State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese
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d
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Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing 100029,
State Key Laboratory of Atmospheric Boundary Layer and Atmospheric Chemistry,
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*
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Address correspondence to Tiantian Li, No. 7 Panjiayuan Nanli, Chaoyang District,
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Beijing, 100021 China. Telephone: 008613671359855, Email:
[email protected] Corresponding Author
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ABSTRACT
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There is a rising concern that fine particle (PM2.5) compositions may play an
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important role in explaining PM2.5-related mortality risks. However, PM2.5
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constituents responsible for these risks haven’t yet been determined. There are few
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PM2.5 constituent-health studies in developing countries. We adopted a time-series
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approach, using generalized linear regression models to examine associations between
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short-term exposure to PM2.5 constituents and mortality, and analyzed data stratified
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by gender and by age groups (74) from 2013–2015 in Beijing,
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China. We also investigated seasonal patterns of such associations. For a 0-day lag,
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interquartile range increases in potassium, calcium, magnesium, and organic carbon
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were associated with 0.51% (95%CI: 0.17-0.85), 2.07% (95%CI: 0.71-3.44), 0.26%,
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95%CI: 0.08-0.44) and 2.65% (95%CI: 0.18-5.18) increases in respiratory mortality;
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and sulfate with 1.57% (95%CI: 0.04-3.12) increases in cardiovascular mortality. In
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the season-stratified analysis, some constituents’ associations (potassium, calcium,
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magnesium, nitrate, sulfate and organic carbon) with respiratory mortality appeared to
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be stronger in cold seasons than in warm seasons. Older adults (65–74) may be
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susceptible to certain compositions. Our findings provide evidence that link PM2.5
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constituents with mortality and suggest that adverse effects vary among constituents
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in different seasons.
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Abstract Art
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KEY WORDS: Fine Particulate; Chemical Constituents; Cause-specific Mortality;
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Susceptible Population; Time series.
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INTRODUCTION
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Recent epidemiologic studies have confirmed that short-term exposure to fine particle
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(PM
