Imaging the Molecular Dimensions and ... - ACS Publications

This model is in good agreement with the observed height distribution of. Con A molecules at the ...... rather, we are trading accuracy for acquisitio...
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J. Phys. Chem. B 1998, 102, 1649-1657

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Imaging the Molecular Dimensions and Oligomerization of Proteins at Liquid/Solid Interfaces Mark J. Waner,† Martha Gilchrist,† Melvin Schindler,‡ and Marcos Dantus*,† Departments of Chemistry and Biochemistry, Michigan State UniVersity, East Lansing, Michigan 48824 ReceiVed: October 2, 1997; In Final Form: December 10, 1997

Individual Concanavalin A (ConA) molecules have been imaged at the liquid/solid interface with an atomic force microscope (AFM). Three-dimensional sizing with very high resolution (