Immunotherapy-focused Cue Biopharma launches - C&EN Global

Jan 30, 2017 - Cue Biopharma has emerged from stealth with $26 million in funding to develop T-cell receptor-targeted biologics. Founded in 2015 with ...
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RENEWABLES

▸ Eastman launches new acetate fiber brand

invest $5 million in green chemistry innovation by 2022. Rival chain Walmart launched a similar policy last July.—MICHAEL MCCOY

OUTSOURCING

Fabric made with Eastman’s Naia fiber.

Eastman Chemical, a maker of cellulose acetate fiber for draperies and bedspreads, has launched a new brand of cellulose acetate filament fiber it has dubbed Naia. Intended for women’s intimate apparel, Eastman says the fiber is made with wood pulp “derived exclusively from sustainably managed and certified forests.”—MARC REISCH

CONSUMER PRODUCTS

▸ Target chain launches chemicals policy The big retailer Target has launched a chemical management policy focused on ingredient transparency and chemicals of concern. By 2020, Target wants full ingredient disclosure for all personal care, baby care, and household products it sells. Those products also must be formulated without phthalates, parabens, formaldehyde, formaldehyde donors, or nonylphenol ethoxylates. By 2022, the chain wants to remove perfluorinated chemicals and harmful flame retardants from all textiles. And Target says it will

▸ IQ-CHem invites ideas on petrochemicals A group of 14 chemical firms have come together to launch IQ-CHem, a competition inviting start-ups to put forward innovative ideas for the petrochemical industry. There is one prize of $20,000, two prizes of $10,000 each, and three prizes of $5,000 each. The application deadline is March 1. IQ-CHem partners include BASF, Dow, Henkel, Sinopec, Solvay, and 3M. The competition will be judged by more than 30 experts representing partner companies, scientific institutions, and investors. In addition to the financial prizes, start-ups with the best proposals will have the chance to collaborate with IQ-CHem partners.—ALEX SCOTT

DRUG DEVELOPMENT

▸ Immunotherapyfocused Cue Biopharma launches Cue Biopharma has emerged from stealth with $26 million in funding to devel-

Business Roundup

CREDIT: EASTMAN CHEMICAL

▸ Versalis, the chemical arm of Italian energy company ENI, and Algerian state oil company Sonatrach have signed an agreement to carry out joint feasibility studies for an integrated chemical complex in Algeria. The two companies signed a cooperation agreement in November. ▸ Trinseo is selling its 50% interest in the Sumika Styron Polycarbonate joint venture to its partner Sumitomo Chemical. Trinseo will continue to market the output of the Ehime, Japan-based polycarbonate plant.

▸ LiquiGlide has raised $16 million in funding in a venture capital round that included Structure Capital, Valia Investments, Struck Capital, and Pilot Grove. The company is based on technology developed at MIT for creating permanently wet and slippery surface coatings. ▸ Intrexon has agreed to acquire the Maryland-based gene therapy company GenVec in a deal worth about $16 million. Intrexon intends to use GenVec’s adenoviral vector gene delivery technology and regulatory compliant manufacturing in developing therapeutics.

op T-cell receptor-targeted biologics. Founded in 2015 with $10 million in seed funding, Cue hopes to tackle cancer and autoimmune diseases by developing biologics that will modulate the activity of specific sets of T cells. By outfitting an antibody with both an engineered T-cell signaling ligand and a peptide complex specific for disease-relevant T cells, Cue can elicit a highly specific response, either stimulating T cells to combat cancer or dampening the T-cell response in autoimmune diseases. The biotech firm has two drug candidates in preclinical studies for cancer.—LISA JARVIS

ONCOLOGY

▸ Merck, BMS settle patent dispute In the latest twist in the heated cancer immunotherapy arena, Merck & Co. has settled its patent dispute with Bristol-Myers Squibb and Ono Pharmaceutical over Merck’s PD1 inhibitor Keytruda. Merck will pay BMS $625 million and provide royalties on global sales of Keytruda through 2026. The deal comes a day after BMS suffered another setback with its PD1 inhibitor, Opdivo. BMS said it was no longer pursuing an accelerated approval of Opdivo combined with cancer immunotherapy agent, Yervoy, as a first-line treatment in lung cancer. In August, Opdivo failed a study as a first-line monotherapy in lung cancer.—LISA JARVIS

▸ Merck KGaA has teamed with Domain Therapeutics to develop adenosine receptor antagonists and other novel cancer immunotherapies. Although financial details have not been disclosed, Merck will provide Domain with research funding in exchange for the global rights to its next-generation adenosine receptor inhibitors.

▸ Enteris BioPharma and Sanofi are exploring the possibility of using Enteris’s small-molecule delivery technology to develop an oral formulation of one of Sanofi’s preclinical-stage peptides. Enteris was set up in 2013 around the drug delivery technology of the now-defunct peptide drug firm Unigene Laboratories.

▸ Aptuit, a contract research provider, is collaborating with the Molecular Surgical Laboratory of Massachusetts General Hospital in the area of antibiotic resistance. Directed by Laurence Rahme, the lab is working to identify and validate new targets in Gram-negative bacteria.

▸ Verily Life Sciences, a subsidiary of Google’s parent company Alphabet, is partnering with Singapore-based Temasek. The Asian investment firm will put $800 million into Verily for a minority stake. Verily is a data-focused developer of life sciences and health care tools and devices.

JANUARY 30, 2017 | CEN.ACS.ORG | C&EN

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