Editorial pubs.acs.org/OPRD
Invited Academic Review
W
e are delighted to introduce an invited manuscript from Professor Neil K. Garg and Tehetena Mesganaw of the University of California at Los Angeles, featuring work from their laboratories on iron- and nickel-catalyzed cross-coupling reactions. The field of nonprecious metal catalysis has seen a great number of contributions in recent years. This academic review (DOI: 10.1021/op300236f) highlights contributions of the Garg laboratory to this field through the utilization of simple activated phenols that have been utilized in cross-coupling reactions. The account describes cross-coupling reactions of boronic acids, the most common reaction for preparation of biphenyls, using nickel. It is followed by advancements in ironmediated Kumada couplings for the formation of C−C bonds, nickel-catalyzed amination reactions, and reductive cleavage of aryl-carbamates. All of these transformations have useful synthetic applications. In the past decade, catalytic reactions in academia and industry have been dominated by the use of precious metals such as palladium aided by numerous phosphine ligands. As more base-metal catalysts are developed and exemplified, it is clear that they will find future applications in the pharmaceutical industry. We thank Professor Garg for his contribution to Organic Process Research & Development.
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Stéphane Caron Chris Senanayake
AUTHOR INFORMATION
Notes
Views expressed in this editorial are those of the authors and not necessarily the views of the ACS.
Published: December 11, 2012 © 2012 American Chemical Society
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dx.doi.org/10.1021/op300255m | Org. Process Res. Dev. 2013, 17, 28−28
