Is it the little things that hurt? - C&EN Global Enterprise (ACS

Not too many years ago, many of our analytical analyses lay in the milligram range. We've refined that in the intervening years until now we confident...
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C&EN Sept. 22, 1975

Editorial

Is it the little things that hurt? Not too many years ago, many of our analytical analyses lay in the milli­ gram range. We've refined that in the intervening years until now we confidently work in the realm of nanograms and picograms. Lest one underestimate this change in analytical levels, it is a significant and unique accomplishment. One in which all chemists can be justifiably proud of their contribution. Remarkably enough, however, this accomplishment seems to create problems rather than generate plaudits. The lower we seem to go in our analysis, the more hazardous our world becomes. Consider, for example, the extremely low levels of chloroform that have been de­ tected (along with many other compounds) in our drinking water. The methods and men of detection are left essentially unnoticed and un­ noted, as we rise up in arms over this contamination of our water sup­ plies. I, for one, am not prepared to add chloroform to my daily diet, but the furor over this chemical seems to indicate that this is actually what's happening to people in cities like New Orleans. How much is there— about 100 ppb? At that level, one would have to be very thirsty to ingest what might be dangerous levels. We need to know it's there and why and work toward reducing or eliminating it if necessary. But this should all be done with the proper perspective to the level of the hazard in­ volved. We seem to daily get tied up in knots over the little things, while the big ones are left unmolested to bury us. It's a well-used comment but the government subsidizes tobacco and smoking (the tobacco subsidy was raised this year in seeming ignorance of their own warning I notice on my pack), at the same time as we seem to be legislating against innocuous levels of other materials. I'm in no way against smoking, but this does seem to illustrate widely varying degrees of legislation. I've always been a "better safe than sorry" individual, but I never felt that that meant an antiseptic life style. No one needs a triple-distilled label on the water supply. For many materials there is a minimum ac­ ceptable level. Selenium is a poison, but try to live without a trace level in your system. With this material, there is an acceptable, and even re­ quired, level. Is it so hard then to accept this same philosophy for other materials—that there is a level below which no dangerous effects will occur? We have a similar fear with arsenic and are working hard to drive it out of use, and yet this material has been shown to have many positive and curative uses. It has been used in chemotherapy and for disease control and treatment in animals and humans. In fact, for those who might be interested, a Dr. D. V. Frost, a consultant in. nutrition biochemistry in Schenectady, N.Y., reported in 1970 that lung cancer has steadily increased in smokers since arsenic compounds were dis­ continued in tobacco processing. Frost feels there is a fair body of evidence suggesting that a relatively high nutrient intake of arsenic may reduce susceptibility to cancer. If we drive down to zero levels for this material, we may do more harm than good. With many others, I remain a staunch advocate of pollution control and cleanup, but we need to take a more sober look at some of our cur­ rent control levels. Massive doses of almost anything are harmful, but a pure extrapolation of this to zero levels of everything doesn't seem to be a necessary and proper corollary. Albert F. Plant

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