Locust Bean Gum in Food Products Fed to Familial

6 Locust Bean Gum in Food Products Fed to Familial Hypercholesterolemic Families and a Type II Patient Downloaded by CALIFORNIA INST OF TECHNOLOGY on January 20, 2018 | http://pubs.acs.org Publication Date: April 11, 1983 | doi: 10.1021/bk-1983-0214.ch006

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JAMES H . Z A V O R A L , P E T E R H A N N A N , C L A R K M . SMITH, BO E . H E D L U N D , M A D G E HANSON, D O N N A FIELDS, K A N T A K U B A , I V A N F R A N T Z , and D A V I D R. J A C O B S , J R . Hennepin County Medical Center, Department of Pediatrics, Minneapolis, MN 55415

Familial hypercholesterolemia (FHC) is associated with severe premature coronary artery disease and death and is resistant to conventional dietary treatment. Locust bean gum (LBG) incorporated into food products was fed to adults and children with FHC. Twenty-eight patients, 18 adults and 10 children were divided into two groups (Group A and Group B), and using a cross-over design were fed identical food products with and without LBG (8-30 gm/d) as outpatients in four-week periods. Three additional adults with different lipid abnormalities were studied using the same protocol. Diet records, food product consumption, lipids, and lipoproteins were analyzed every two weeks. Total cholesterol (C) was lowered 11% (275 to 246 mg%) in Group A at four weeks (p