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O:;NOH ο Ν - Hydroxyphthalimide
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4-Amino-
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Science
this loop would straddle the phosphodiester bond between the β- and γ-phosphates of GTP. This bond is the prime candidate to be the cata lytic site for GTP hydrolysis in the normal protein. The loss of two hy drogen bonds may alter the orien tation of the jS-phosphate group, Kim says, and thus somehow inter fere with the hydrolytic reaction. Working out the complete mech anism of loss of GTPase activity will require determination of the struc ture of native and mutant ras pro teins bound to GTP. This effort is complicated by the proteins' hydrol ysis of GTP. Thus the work must be carried out on crystals of the pro teins bound to GTP analogs that
contain a bond between the β- and 7-phosphates that is not susceptible to hydrolysis. Efforts to produce crystals of such complexes are un der way in Kim's laboratory. The similarity of structures be tween the mutant and the normal ras proteins may complicate efforts to develop a drug to deactivate the mutant protein and thus halt tumor growth. "The drug must deactivate the mutant form of the protein with out deactivating the normal protein, which is essential to normal cell growth," Kim points out. "It's going to be a difficult job, but it's theoret ically possible. Chemists are pretty clever." Rudy Baum
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EDUCATION
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Management-of-technology program debuts 2,6-Dimethylpiperidine, cis 2,4-Diamino1,3,5-trimethylbenzene (2,4-Diaminomesitylene)
CHft
NH2 H , C ^ NHL
5-Nitroisophthalic acid
and derivatives
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Custom synthesis against secrecy agreement Our traditional processes: • nitration • catalytic hydrogénation and other reactions US-Agents:
HENLEY CHEMICALS, INC. 50, Chestnut Ridge Road Montvale, NJ 07645 Phone (201)307-0422 FAX (201) 307-0424
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34
CIRCLE 29 ON READER SERVICE CARD January 16, 1989 C&EN
Satellite broadcasting signals this month are carrying the first courses in a new master of science program initiated by National Technological University in management of tech nology. NTU plans to have the com plete two-year program available in June. NTU, based in Fort Collins, Colo., is the first electronic university ded icated to nationwide satellite broad casting of graduate-level advanced engineering and technical educa tion. An accredited, private, non profit institution founded in 1984, it is a university without a campus or permanent faculty, and is de signed to serve the advanced edu cation needs of busy, mobile engi neers, scientists, and technical man agers. Ranging from the University of Massachusetts in the Northeast to the University of Arizona in the Southwest, some 28 institutions par ticipate in the network. So far, NTU's focus has been fair ly electrical in nature. The new pro gram brings the number of M.S. programs offered to six. The other five are computer engineering, com puter science, electrical engineer ing, engineering management, and manufacturing systems engineering. "Management of technology has been identified as one of the top national priorities, especially in view
of the intensity of international com petition," says Robert W. DeSio, vice president for development and longrange planning for NTU. "Because management of technology is a rel atively new discipline and interdis ciplinary in nature, a traditional uni versity would have difficulty in bringing together the required ed ucational programs," he adds. NTU is in the second phase of development of the new program. The first phase focused on format and curriculum. Students will be nominated to the program by each of NTU's 60 spon soring corporations and government agencies. They will be managers who are expected to advance into senior corporate management dur ing their careers. They will have the financial support of their cor porations or agencies and will be freed from enough of their regular responsibilities to finish the pro gram in 24 months. Students will as usual take courses at their work sites through NTU's instructional television network. But in a departure from the format of other NTU programs, they will be brought together during the twoyear period for seven one-week in tense residencies at different par ticipating university campuses. James Krieger
