MEETINGS
ACS Central Regional Meeting The ACS 15th Central Regional Meeting and the Ohio Valley Chromatography Symposium will be held jointly at Miami University in Oxford, Ohio. The Cincinnati ACS Local Section will host the meeting on May 23-25. The Miami University Campus is located 35 miles northwest of Cincinnati at the intersection of highways US-27 and Ohio-73. For the meeting, limousine service will be provided from the Greater Cincinnati Airport; reservations for this transportation must be made on the advance registration form (see page 57). The three-day meeting will feature 19 symposia. A special Ohio Valley Chromatography Symposium is scheduled each day of the meeting. On Tuesday, an all-day High School Chemistry Teacher's Workshop is planned. Contributed papers will be presented in podium form, except where specifically noted as posters. The technical program will begin on Monday morning with a plenary session. The address, "How Do Enzymes Work?" will be delivered by Nobel Laureate William N. Lipscomb. Educa tional displays will feature the latest computers, laboratory equipment, chemicals, and textbooks. Attendees are encour aged to visit these exhibits at the Shriver Center. Special meeting events include a Monday evening mixer in the Heritage Room of the Shriver Center. The Central Regional ACS Award for High School Teaching will be presented at the awards luncheon on Tuesday in the Marcum Center. Advance registration is recommended and necessary for those wishing campus housing, meals, special events, and /or airport limousine service. Advance registration fee for mem bers is $25 ($7.00 for students, high school teachers, and tech nicians). The advance registration form must be returned by May 6. Advance registration will be acknowledged. However, registration materials and housing, meals, and special event vouchers will not be mailed, but may be picked up at Shriver Center of Miami University on Sunday from 3 to 6 PM or
Plenary Session
Monday from 8:30 to 11 AM. On-site registration will be at the Shriver Center on Sunday from 3 to 6 PM, Monday from 8:30 to 11:00 AM, and on Tuesday and Wednesday from 8:30 to 10:00 AM. Extra copies of the abstract book will be available at the meeting for an additional $10. Dormitory housing is available in University residence halls; most rooms are for double occupancy, but a limited number of single rooms are available. Persons wishing to share a double room should file forms together. Housing will be available from Sunday through Tuesday nights. Meals from Monday breakfast through Wednesday lunch are available in university dining halls. Campus room and meal reservations must be made by completing the appropriate section on the advance registration form. Only campus housing is being handled by the meeting. Off-campus housing in the immediate area is limited, and ar rangements must be made directly (check the appropriate space on the registration form). An ACS National Employment Clearing House (NECH) will be operated during the meeting at the Shriver Center. Regis tration for candidates (ACS members and student affiliates only) will begin Sunday from 6:30 to 8:30 PM. Candidates are urged to register early, in advance if possible, since interviews are scheduled a half day in advance. Both candidates and em ployer representative must be registered in attendance at the meeting. The fee to employers, in addition to meeting regis tration, is $25. Employers unable to attend may submit open ings ($25 each). NECH forms for candidates and employer representatives may be obtained from the ACS Employment Aids Office, 1155—16th St., N.W., Washington, D.C. 20036. Please specify the Central Regional Meeting to facilitate han dling; all forms must be sent to ACS headquarters no later than May 16. For any additional information contact John R. Grunwell, Miami University, Oxford, Ohio 45046.
3:45—4. Mass Spectrometry Studies of Fragmentation Processes. R. W. Kiser 4:30—5. Low Energy Ion-Molecule Reactions as Structure Elucidation Tools. T. Keough
SPECIAL EVENTS MONDAY MORNING Hall Auditorium MONDAY
M. D. Francis, Presiding
8:30—11:00 AM Registration. Shriver Center 11:00—Plenary Lecture. Hall Auditorium, Shriver Center 3:00—10:30 PM Chemical Exposition open. Heritage Room, Shriver Center 9:30—10:30 PM Mixer. Heritage Room, Shriver Center
11:00—Introductory Remarks. J. R. Grun well 11:15—1. How Do Enzymes Work? W. N. Lipscomb Jr.
TUESDAY
ANALYTICAL CHEMISTRY
8:30—10:00 AM Registration. Shriver Center 9:00—6:00 PM Chemical Exposition. Heritage Room, Shriver Center 11:45 AM—12:45 PM Awards Luncheon. Shriver Center 5:00—6:30 PM ACS Local Section Officers and Councilors Meeting, Conference Room, Marcum Conference Center WEDNESDAY 8:30—10:00 AM Registration. Shriver Center 9:00 AM—12:00 Chemical Exposition. Heri tage Room, Shriver Center 11:00 AM—1:00 AM ACS Central Region Steering Committee, Conference Room, Marcum Conference Center 54
April 1 1 , 1983 C&EN
Section Β
2:00—6. Capillary GC-FTIR. S. L Smith 2:45—7. Factor Analysis Methods for Real Time GC-FTIR Chromatogram Recon struction. P. M. Owens 3:30—Intermission 3:45—8. Computer Controlled Multi-detection in HPLC. S. Gates 4:30—9. Computer Assisted Structure Re tention Relationships for Chlorinated Dibenzofurans. M. Hale
D. W. Leedy, Chairman
MONDAY AFTERNOON
Hughes, Room 100 Ohio Valley Chromatography Symposium on Chromatography—I. Application of Computers to Chromatographic Tech niques J. A. Graham, Presiding
Section A
Shriver Center Towers Symposium on Mass Spectrometry—I. New Techniques and Applications A. J . DeStefano, Presiding 2:00—2. Mass Spectrometry and Environ mental Analysis. W. L. Budde 2:45—3. New Mass Spectral Techniques for Characterizing Toxic Chemicals. T. O. Tiernan 3:30—Intermission
Section C Shideler, Room 115 Symposium on Electrochemistry—I. Ana lytical and Mechanistic Electrochemistry of Biological Systems R. L. McCreery, Presiding 2:00—10. Strategies for Voltammetric Im munoassay. W. R. Heineman, M. J. Doyle, K. R. Wehmeyer, H. M. Eggers, D. S. Wright, Η. Β. Halsall
2:45—11. Surface Enhanced Raman Spec troscopy of Biomolecules Adsorbed at Silver Electrodes. T. M. Cotton 3:30—Intermission 3:45—12. Electrochemical Determination of Polycyclic Aromatic Hydrocarbons at a Carbon Paste Electrode. Η. Υ. Cheng 4:30—13. Liquid Chromatography/Electrochemistry: Determination of Nonelectroactive Substances Using Pre- and PostColumn Reactions. W. Jacobs, C. Lavich, P. Kissinger Hughes, Room 153 Section D General Session on Instrumentation F. J. Holler, Presiding 2:00—14. Fast Reaction Kinetics by Microdroplet Mixing with Raman Spectroscopic Detection. S. F. Simpson, F. J. Holler, J. R. Kincaid 2:20—15. Temporal Optimization of Reaction Rate Methods—the Influence of Instru mental Errors. R. K. Calhoun, F. J. Holler 2:40—16. Characterization of a High Perfor mance Automated Stopped-Flow Instru ment. A. Engh, F. J. Holler 3:00—17. Apple II Plus Microcomputer as a Laboratory Instrument. S. P. Molnar, A. M. Brongersma 3:20—Intermission General Session on Alkali Metal Analysis
G. E. Pacey, Presiding 3:35—18. Spectrophotometric Determination of Lithium by Ion-Pair Extraction with Cryptand 211 Complex and a Monoanionic Dye. Y. P. Wu, G. E. Pacey
3:55—19. Photometric Determination of Al kali Metal Ions Using a New Chromogenic Crown Ether. G. E. Pacey, K. Sasaki 4:15—20. Trace Analysis Using Crown Ethers. B. P. Bubnls, G. E. Pacey 4:35—21. Fluorescent Detection of Alkali Metals Utilizing Crown Ethers. J. L. Steger, G. E. Pacey 4:55—22. Neutral Carrier Coated Wire Elec trodes. D. A. Hollowed, G. E. Pacey
2:00—40. Clinical Applications of Mass Spectrometry. S. P. Markey 2:45—41. Applications of Mass Spectrometry in the Pharmaceutical Industry. L. Baczynskyj 3:30—Intermission 3:45—42. Application of Isotope Ratio Mass Spectrometry in Biomedicine and Bio chemistry. J. M. Hayes 4:30—43. Applications of Mass Spectrometry in Toxicology. R. L. Foltz
MONDAY EVENING Hughes, Room 120 General Session on Electrochemistry P. A. Forshey, Presiding 6:30—23. Cross-linked Polymer Modified Electrodes. E. S. DeCastro, J. E. Mark, W. R. Heineman 6:50—24. Electrochemical and Spectro scopic Characterization of Cupric Hexacyanoferrate Thin Films. L. M. Siperko, T. Kuwana 7:10—25. Long Optical Pathlength Spectroelectrochemistry Using Tubular Elec trodes. M. D. Porter, P. A. Forshey, T. Ku wana 7:30—26. Mean-Square Electric Field vs. Vibrational Surface Analysis Using Fourier Transform Infrared External Reflection and Photoacoustic Spectroscopy. M. D. Porter, D. H. Karweik, T. Kuwana, W. B. Theis, G. B. Norris, T. O. Tiernan 7:50—27. Development of an Enzyme Elec trode for the Determination of Flavin Ade nine Dinucleotide. A. R. M. Yatim, T. L. Riechel TUESDAY MORNING
Section A
Shideler, Room 215 Symposium on Mass Spectrometry—II. New Techniques and Applications A. J . DeStefano, Presiding 9:00—28. Fourier Transform Mass Spec trometry. B. S. Freiser 9:45—29. Applications of Some New Tech niques in Mass Spectrometry. M. L. Gross 10:30—Intermission 10:45—30. Molecular Synthesis by Mass Spectrometry. R. G. Cooks 11:30—31. Fast Atom Bombardment Mass Spectrometry. K. L. Rinehart Section Β Hughes, Room 100 Symposium on Chromatography—II. Inno vations in Chromatographic Detectors G. Hess, Presiding 9:00—32. Laser Excitation for Chromato graphic Detection. M. J. Sepaniak 9:45—33. Microwave Plasma Emission De tection. J. A. Caruso 10:30—Intermission 10:45—34. Laser Enhanced Ion Spectroscopy as a Chromatographic Detector. R. B. Green 11:30—35. Laser Modulated Electron Capture Detection in Gas Chromatography. N. Dovlchl
Section C Shriver Center Towers Symposium on Electrochemistry—II H. B. Mark Jr., Presiding 9:00—36. Fiber(ous) Electrodes in Mecha nistic and Brute Force Biochemical Inves tigations. C. W. Anderson 9:45—37. Oxidation of Ascorbate at Carbon Electrodes. R. M. Wightman 10:30—Intermission 10:45—38. Development and Use of Multi channel Electrochemical Centrifugal Ana lyzer. H. K. Cho, R. Couch, A. Liao, J. M. Jagadeesk, C. L. Olson 11:30—39. Molybdenum Modified Polymeric Sulfur Nitride, (SN)X, Electrodes as Model Systems for the Elucidation of Nitrogenase Reactions. H. B. Mark Jr., J. F. Robinson, L. Laguren TUESDAY AFTERNOON
Section A
Hughes, Room 100 Mass Spectrometry—III. Biochemical Ap plications of New Techniques in MS D. C. DeJongh, Chairman
Section Β Shideler, Room 115 Electrochemistry—III F. Shultz, Presiding 2:00—44. Spectroelectrochemical Exami nation of Fast Biological Charge Transfer Reactions. J. S. Mayausky, R. S. Robinson, R. L. McCreery 2:45—45. Applications of Pulse Voltammetry to Problems in Pharmacology. J. G. Osteryoung 3:30—Intermission 3:45—46. Potentiometric Gas Sensors: Re cent Advances in Design and Bioanalytical Applications. Μ. Ε. Meyerhoff 4:30—47. Electrochemistry of Molybdenum Coordination Compounds. J. R. Bradbury, F. Schultz
Section C Culler, Room 46 General Session—High Performance Liquid Chromatography . N. D. Danielson, Presiding 2:00—48. Determination of Indomethacin in Serum and Urine. D. R. Burgard, M. D. Francis 2:20—49. Internal Phase Extractin Precolumn for the HPLC Analysis of Drugs in Serum. T. C. Pinkerton, H. I. Hagestam 2:40—50. Microbore HPLC Determination of Epinephrine and Norepinephrine Using Fluorescence Detection. J. H. Mike, T. W. Gilbert 3:00—51. Determination of Nitrate in Drinking Water and Liquid Food Samples by HPLC. D. C. Serti, P. H. Davis 3:20—Intermission 3:35—52. Picoline Modified Kel-F as a Col umn Packing Material for HPLC. M. Kruempelman, N. D. Danielson 3:55—53. Reaction of Kel-F 6300 with Grignard Reagents for HPLC. S. Ahmed, N. D. Danielson 4:15—54. Multiwavelength UV/VIS/Fluorescence HPLC Detector. D. G. Jones, D. O. Landon 4:35—55. Quantitative Aspects of Microbore HPLC with Fourier Transform Infrared Spectrometric Detection. C. C. Johnson, L. T. Taylor 4:55—56. Withdrawn
TUESDAY EVENING Hughes, Room 120 General Session—Gas Chromatography J. A. Caruso, Presiding 7:00—57. Utilization of a Supercooled Nematic Liquid Crystal for the GLC Analysis of Single-Ring Aromatic Compounds. J. E. Haky, B. Leja, T. M. Stickney, H. G. Schneider 7:20—58. Purity Determination of Several Chlorinated Dioxins by Differential Scan ning Calorimetry and Gas Chromatography. P. J. Slonecker, J. S. Cantrell, J. L. Pyle 7:40—59. Application of a He MIP-RSS (Rapid-Scanning Spectroscopy) Coupled to Gas Chromatography for Multi-Element Detection of Halogens. M. Zerezghi, K. J. Milligan, J. A. Caruso 8:00—60. Application of Capillary Column Gas Chromatography to Analyses of Polar Organic Compounds. J. R. Morrison, W. R. Godbey, C. A. Abatjoglou 8:20—61. Gas Chromatography of OrganoMercurials: Passivation of the Column with Halide Salts. J. E. O'Reilly, J. Jaafar 8:40—62. Direct Determination of Oxygen ated Compounds in Complex Mixtures by Capillary Gas Chromatography. J. M. Levy, L. E. Wolfram, J. A. Yancey
WEDNESDAY MORNING
Section A
Shriver Center Towers Symposium on chromatography—III. Inno vations In Chromatographic Techniques
BIOCHEMISTRY B. Halsall, Chairman
F. Hileman, Presiding 9:00—63. Chromatography with Supercritical Carbon Dioxide. D. R. Gere 9:45—64. Modification of Fluorocarbon Polymers by Organometallics for HPLC. N. D. Danielson 10:30—Intermission 10:45—65. Micro-flame Ionization Detector (MFID)/Radioactivity Detector (RAD) for Fused Silica Capillary Columns. P. A. Ro driguez, C. L. Eddy 11:30—66. Liquid Chromatography/Electrochemistry: Improvements with Multiple Electrode Detection. L. A. Allison, G. S. Mayer, R. E. Shoup WEDNESDAY MORNING
Section Β
Hughes, Room 153 General Session—Mass Spectrometry T. Keough, Presiding 9:00—67. Developments in Fourier Transform Mass Spectrometry. T. J. Carlin, B. S. Freiser 9:20—68. Aspects of MS/MS Encountered Using a Hybrid Tandem Mass Spectrome ter. M. J. DeKrey, R. G. Cooks 9:40—69. Collision-induced Dissociation Utilizing Fourier Transform Mass Spec trometry: A Comparison and Character ization. L. Saltans, B. S. Freiser 10:00—70. Functional Group and Structural Analysis of ICR Spectra With Pattern Rec ognition. M. M. Ku, B. S. Freiser 10:20—Intermission 10:35—71. Studies of the Gas Phase Reac tions of Group 8 Transition Metal Ions (Fe + , Co + , Ni+) with Linear Alkanes Using Fourier Transform Mass Spectrometry. D. B. Jacobson, B. S. Freiser 10:55—72. Organic Dyes Characterized by Desorption Ionization Mass Spectrometry. S. M. Scheifers, S. Verma, R. G. Cooks 11:15—73. Structural Determination of C 7 H 7 0 + Ions in the Gas Phase by Ion Cy clotron Resonance Spectroscopy. C. J. Cassady, B. S. Freiser 11:35—74. Study of the Collision-Induced Dissociation of Ester Enolate Ions Using FTMS. S. W. Froelicher, R. R. Squires, B. S. Freiser Section C Hughes, Room 152 General Session—Spectroscopy F. L. Fricke, Presiding 9:00—75. Simultaneous Determination of Volatile Elemental Hydrides and Other El ements by Inductively Coupled Argon Plasma Emission Spectrometry Using a Glass Frit Nebulizer. R. D. Satzger, E. Bonnin, F. L. Fricke, J. A. Caruso 9:20—76. Evaluation of a Low-Power, LowFlow Inductively Coupled Plasma Torch for the Analysis of Foods and Biologicals. K. A. Wolnlk, F. L. Fricke, C. M. Gaston 9:40—77. Chemical Modification of Blood and Urine Matrices in the Determination of Aluminum and Nickel by Graphite Furnace Atomic Absorption Spectrometry. T. W. Brueggemeyer, R. D. Stazger, F. L. Fricke 10:00—78. Electrothermal Vaporization for Sample Introduction in Atomic Spectros copy. K. C. Ng, J. A. Caruso 10:20—Intermission 10:35—79. Use of Organic Solvents with a Glass Frit Nebulizer in Inductively Coupled Plasma Spectrometry. W. Nisamaneepong, J. A. Caruso 10:55—80. Infrared Spectral Compression Technique for Resolution Independent Search Systems. P. M. Owens, T. L. Isenhour 11:15—81. Isotope Dilution Analysis of Coal Sulfur. G. C. Huston, D. M. Downey
TUESDAY EVENING Hughes, Room 153 General Poster Session 7:00—9:00-82. Distinct Zinc Binding Site in the a-Lactalbumins Regulates Calcium Binding. Is There a Physiological Role for this Control? K. Murakami, L. J. Berliner. 83. Interactions of Human Orosomucoid with Steroids and Basic Drugs. M. L. Friedman, T. L. Kirley, H. B. Halsall 84. Voltammetric Enzyme Immunoassay for a! r Acid Glycoprotein at a Carbon Paste Electrode. M. J. Doyle, H. B. Hal sall, W. R. Heineman 85. Effects of Dexamethasone Phosphate on Type I Collagen Fibrillogenesis. G. Dombi, H. B. Halsall 86. Refolding of Trypsinogen Monitored by HPLC. J. N. Higaki, A. Light 87. Fluorescent Probe Study of the Confirmational Change in Cytochrome C upon Reduction. R. A. Magnottl Jr., M. J. Simone, G. P. Kreishman 88. Reaction of the Environmental Con taminant, Cyanogen (Ethanedinitrile), with Proteins. R. L. Tharp, R. A. Day 89. Ganglioside Composition of Human Normal and Cataractous Lens; R. T. Swindell, H. Harris, L. M. Buchanan, B. Albers-Jackson 90. Effects of the Psychotropic Drug, Chlorpromazine, on Chloride Efflux Across Human Erthyrocyte Membranes. M. Nicholas, D. A. Burterfield 91. Redox Activation of Galactose Oxidase: A Thin-Layer Electrochemical Study. J. M. Johnson, H. B. Halsall, W. R. Heineman 92. Oxazinone Formation From a-Ketoacids and Oxalic Acid. Nature of the Re action. J. Baatz, R. A. Day 93. Studies of the Interaction of Phlorizin Analogs with the Spinach Chloroplast Coupling Factor: Inhibition by Gossypol. H. Riethman, G. D. Winget 94. Etheno Adenine Nucleotides Interac tions with Human Platelet Receptors. B. H. Ragatz, P. G. latridis, S. G. latridis 95. Acetylation and Deacetylation of Sugar Nucleotides. M. A. Salam, G. A. Gordon, E. J. Behrman 96. CIS-(NH3)2Ptcl2 Unwinds Supercoiled DNA More Effectively than Trans(NH3)2PtCI2. F. R. Collart, W. M. Scovell 97. Dipsticking of a NDA Major Groove with Spin Labels. C. R. Toppin, S. C. Kao, I. E. Thomas, J. C. Ireland, A. M. Bobst 98. Sequence and % (G+C) Content of DNA Markedly Affects the Difference in S1 Nuclease Sensitivity on Cis- and Trans-(NH3)2PtCI2 Modified DNAS. V. J. Capponi, W. M. Scovell 99. Model for the Interaction of CISPtCI2(NH3)2 with SV40 DNA. W. M. Scovell
WEDNESDAY MORNING Hughes, Room 100 Symposium on Biochemistry: Functional Linkage in Macromotecular Systems B. Halsall, Presiding 9:00—Introductory Remarks 9:10—100. Linked Functions in E. Coli As partate Transcarbamylase. N. M. Allewell 9:50—101. Role of Subunit Interaction in the Regulation of Rabbit Muscle Phosphofructokinase. J. C. Lee 10:30—102. Linkage Between Ligand Binding and Protein Associations: Sedimentation Behavior and Ligand Binding Isotherms. J. R. Cann, W. B. Goad 11:10—Intermission 11:20—103. Coupling Between Enzyme Ca talysis and Proton Pumping in ATP Syn thesis/Hydrolysis. G. G. Hammes 12:00—104. Relationship of the Actomyosin ATPase Activity to the Mechanism of Muscle Contraction. E. Eisenberg 12:40—105. Linkages in the Microtubule System. R. C. Williams Jr., H. W. Detrich
April 11, 1983 C&EN
55
Meetings CHEMICAL EDUCATION V. Kumar, Chairman MONDAY AFTERNOON Marcum Conference Center Symposium on Chemical Education: Micro computers In Chemistry 2:00—106. Microcomputer-Based Methods in Chemistry. D. J. Macero 3:00—107. Electronic Chemistry Set: Teaching with Computers. J. W. Moore
2:30—124. University Perspectives on Sponsored Research. T. Kuwana 3:00—125. Monsanto External Research and Development Program. T. L Tolbert 3:30—Intermission 3:45—126. Procter & Gamble University Ex ploratory Research Program. P. W. Grounds 4:15—127. Allerton Analytical Confer ences—an Example of University-Industrial Cooperative Problem Solving. T. A. Nieman 4:45—128. Council for Chemical Research: University-Industry Interaction. A. L. Kwiram
TUESDAY AFTERNOON
MONDAY EVENING Hughes, Room 100 General Session A. M. Sarquis, Presiding 6:30—108. Inexpensive Computer Network for CAI. K. B. Gehrlng, J. W. Moore 6:50—109. Microcomputer/User/Instrument Interface—the Course. E. T. Contis 7:10—110. Study of Fluoride Perovskites: A Solid State Chemistry Experiment. C. K. Schmitz, M. B. Langley, R. H. Langley 7:30—111. Science Talent Searches on the Skids. W. Cory 7:50—Intermission 8:00—112. Cooperative Education for the Chemistry Major of a Liberal Arts Institution. R. M. Mueller 8:20—113. Syllabus for the One Semester Chemistry Course for Health Professions. J. L. Sarquis 8:40—114. Kinderchem: Science for the Very Young. R. D. Barnes 9:00—115. Chemical Education pH of Natural Waters. B. V. Weldner
TUESDAY MORNING & AFTERNOON Marcum Conference Room High School Teachers Workshop A. M. Sarquis, Presiding 9:00—11:00. Workshop I. Electron in Motion. Dreyfus Foundation Master Teachers 2:00—5:00. Workshop II. Electrons in Motion. Dreyfus Foundation Master Teachers
TUESDAY EVENING Hughes, Room 100 General Session C. Slater, Presiding 7:00—116. Teaching of Canonical Structures for Complex Species. D. H. McDanlel 7:20—117. Video Tape on the SN2 Mecha nism. G. Franzen 7:40—118. Successful Methods for Teaching Chemical Instrumentation. Pat I: Operation and Care of Instruments. A. A. Hicks. J. C. Swartz 8:00—119. Successful Methods for Teaching Chemical Instrumentation. Part II: Theory of Instrumentation. J. C. Swartz, A. H. Hicks 8:20—Intermission 8:30—120. Using Pourbaix Diagrams in the Classroom. D. H. McDanlel, J. J. Alex ander 8:50—121. Can the Teaching of Bonding be Improved? L. C. Grotz 9:10—122. Bridging the Gap Between High School and College Chemistry. H. L. Haight, B. L. Hawbecker
INDUSTRIAL AND ACADEMIC RELATIONS T. J. Logan, Chairman MONDAY AFTERNOON Marcum Center, Room 102 Symposium on Academic and Industrial Relations 2:00—123. Promoting University-Industry Interactions Through Liaison Programs. K. Tamaribuchi
56
April 11, 1983 C&EN
10:30—145. Acidic vs. Hydridic Character of Organometallic Hydride Complexes. M. G. Gatter, Β. Ε. Bursten 10:50—146. Electronic Structural Studies of Organouranium Complexes. A. Fang, Β. Ε. Bursten 11:10—147. Reduction Chemistry of [Fe(NO)2(M-SR)]2. C.-N. Chau, A. Wojcicki 11:30—148. Ligand Additivity as Observed in the f {"* Transition of Quadruply Bonded Molybenum Dimers. P. E. Fanwick 11:50—149. Electron Transfer in the MixedValence Triiodide Salt of 3-Acetylbisfulvalenediiron. M. F. Moore, D. N. Hendrickson
INORGANIC CHEMISTRY E. Deutsch, Chairman MONDAY AFTERNOON Hughes, Room 150 General Session—Organometallic thesis
Syn
A. Wojcicki, Presiding 2:00—129. Cleavage of the Octachlorodirhenate Dianion by Aryl Isocyanides. C. J. Cameron, R. A. Walton 2:20—130. Synthesis and Derivatization of Mixed Nitrosyl-lsocyanide Complexes of Chromium. R. A. Walton, D. E. Wigley 2:40—131. Reduction of [Fe(C03)PPh2]2 and [Fe(NO)2PPh2|2 and Reactions of a New Dianion, l(C0)3Fe(M-PPh2XM-C0)Fe(CO) 2 PPh 2 ] 2 -. Y.-F. Yu, A. Wojcicki 3:00—132. Transition Metal Alkyls Via Cocondensation of Alkyl Radicals and Metal Atoms. D. W. Flrsich, T. Bierschenk, W. Bailey, R. J. Lagow 3:20—Intermission 3:30—133. Synthesis, Reactivity, and Prop erties of Metal Complexes Containing Substituted Dichalocogenide Ligands. J. E. Hoots, B. Rauchfuss 3:50—134. Synthesis and Characterization of Mixed-Metal Mercaptide-Bridged Com pounds. C. J. Ruffling, T. B. Rauchfuss 4:10—135. Synthesis of Metal locenes by Phase Transfer Catalysis. F. R. Lemke, B. Jacobson, J. Hill, R. H. Langley 4:30—136. Synthesis of Molybdenum Vinylidene Complexes. P. N. Nickias, J. P. Selegue 4:50—137. Preparation and Reactivity of DI(-Hetero-Atom Substituted Alkyl) Zirconocene Derivatives, (r?5-Cp)2Zr[CH(XR)R'] 2 . E. A. Mintz, A. S. Ward MONDAY EVENING Shriver Center Towers Symposium on Inorganic Chemistry in Biol ogy and Medicinal Chemistry E. Deutsch, Presiding 6:30—138. Chemistry of New Technetium Heart Imaging Agents. K. Libson 7:10—139. HPLC Studies of Technetium Complexes Used in Nuclear Medicine. W. R. Helneman, J. P. Zordda, K. Libson, S. Tanabe, E. Deutsch 7:50—140. New Observations on Calcium in Cellular Activity. M. D. Francis TUESDAY MORNING Hughes, Room 150 General Session on Organometallic Chem istry J. Alexander, Presiding 9:00—141. Chemical Reactivity of the Binuclear Zirconocene Hydride, [(η5C5H4CH3)2ZrH(M-H)]2. S. B. Jones, J. L. Patterson 9:20—142. EPR Studies of Paramagnetic BIS(Cyclopentadienyl)Niobacyclic Com plexes. K. E. Howard, J. Z. Liu, J. L. Pet ersen 9:40—143. [Re2CI4(PMe2Ph)4]n+ (n = 2, 1 or 0): A Series of Complexes with Metal-Metal Bond Orders of 4,3.5, and 3. K. R. Dunbar, R. A. Walton 10:00—144. Formation of [Re2H7(PR3)4(NCR)]PRe: Oxidation and Solvolysis of Re2H8(PR3)4. J. D. Allison, R. A. Walton 10:20—Intermission
Hughes, Room 150 General Session on Medicinal and Inorganic Chemistry J. Benedict, Presiding 2:00—150. Synthesis and Characterization of TRIS(BIS(1,2-Dimethylphosphino) Ethane)-Technetium(l), [99-Tc(dmpe)3]^, and Preparation of its 99m-Tc Analog. J. L. Vanderheyden, K. Libson, A. R. Ketring, E. Deutsch 2:20—151. Synthesis and Characterization of Technetium(V) 8-Quinolinolato Com plexes. B. E. Wilcox, E. A. Deutsch 2:40—152. Formation of and Equilibrium Between Some Five- and Six-Coordinate Halo-Oxo Technetium (V) Complexes. R. W. Thomas, M. J. Heeg, R. C. Elder, E. A. Deutsch 3:00—153. Carboranyl Phosphonate Deriv atives. T. O. McCullough, J. J. Benedict, R. A. Wolfgang 3:20—Intermission 3:30—154. EXAFS of Gold Anti-Arthritic Drugs. M. K. Eidsness, R. C. Elder 3:50—155. Use of X-ray Absorption Near Edge Spectroscopy to Determine Oxidation State and Identity of Ligating Atoms in Gold Complexes. J. D. Doi, R. C. Elder 4:10—156. Iron Porphyrin Dimers. D. R. En glish, D. N. Hendrickson, K. S. Suslick 4:30—157. Synthesis and Electrochemistry of Vanadium Complexes with Cysteine and Glutathione. T. L. Riechel
TUESDAY EVENING Marcum Conference Room Symposium on Inorganic Chemistry In Biol ogy and Medicinal Chemistry E. A. Deutsch, Presiding 7:00—158. Interaction of CIS-Platin and DNA. C. J. Lock 7:40—159. Metabolism of Gold-Based Drugs Used in the Treatment of Rheumatoid Ar thritis. R. C. Elder, K. G. Tepperman, M. K. Eidsness, J. D. Doi 8:20—160. Structural Insights, Composition, and Properties of the FeMo Cofactor of Nitrogenase. W. E. Newton, Β. Κ. Burgess, S. Lough, J. W. McDonald, F. A. Schultz 8:50—161. Chelating Agents for Toxic Metal Decorporation. M. M. Jones
WEDNESDAY MORNING Hughes, Room 150 General Session on Electrochemical and General Inorganic Chemistry T. Riechel, Presiding 9:00—162. Electrochemistry of Technetium Tertiary Diphosphine Complexes. A. Ichimura, E. Deutsch, W. R. Heineman 9:20—163. Electrochemical Studies of Vanadyl and Thiovanadyl Schiff Base Complexes. R. SeangprasertklJ, T. L. Rie chel 9:40—164. Electrochemical Characterization of Asymmetric Axial Adducts of Dirhodium Tetra-t-Butyrate. L. S. Fox, B. E. Bursten 10:00—165. Studies of Ruthenium Nitroysyl Porphyrins. A. R. Newman 10:20—Intermission 10:30—166. Resonance Raman Studies of Polypyridine Ruthenium(ll) Complexes. S. McClanahan, J. Kincaid
10:50—167. Synthesis, Characterization, and Single Crystal Structural Analysis of the N-Bonded Sulfonamide Cobalt(lll) Complex [(EN)2Co(NHS(0)2CH2CH2NH2)] CI 2 . Ki netics of the Periodate Oxidation of [(EN)2Co(S(NH2)CH2CH2NH2)](C104)3. M. E. Noon, S. David, L. Roecker, R. C. Elder, E. Duetsch 11:10—168. Cluster Ion Formation from Silver Carboxylates Characterized by Mass Spectrometry/Mass Spectrometry and SIMS. K. L Busch, K. V. Wood, R. G. Cooks 11:30—169. Gas Phase Reactions of Y + Ions with Alkanes using Ion Cyclotron Reso nance Spectrometry. M. B. Wise, B. S. Freiser 11:50—170. 2N Framework Electron Clus ters: The Synthesis, Bonding, and Chemical Reactivity of Tetraboron Tetrachloride. J. A. Morrison, S. L. Emery
ORGANIC CHEMISTRY J. Grunwell, R. Parker, Chairmen
MONDAY MORNING & AFTERNOON Shideler, Room 10 General Session on Synthetic Methods D. Ager, Presiding 2:00—171. Olefin Synthesis via Fragmenta tion of Hindered Ester Halides. J. L. Belletire, D. R. Walley 2:20—172. Cyclization/Elimination of Trimethylsilylketene Adducts. R. T. Taylor, R. A. Cassell 2:40—173. Silylcyclopropanes. New Syn thetic and Mechanistic Studies. G. J. Wells, T. Uchida, L. A. Paquette 3:00—174. Regie- and Stereo-chemical Definition of Silatropic Migration within Trimethylsilyl Substituted Isodicyclopentadienes. P. Charumilind, L. A. Paquette 3:20—Intermission 3:30—175. Approaches to Fused Ring Sydnones. K. Turnbull 3:50—176. N-Dimethylaminopropylation in a Solid-Liquid Two Phase System: Syn thesis of Chlorpromazine, Its Analogs, and Related Compounds. S. J. Schmolka, H. Zimmer 4:10—177. Translocative Rearrangements: Mechanism and Generalization. F. T. Oakes, N. J. Leonard 4:30—178. Diaminobipyridine and TPI Poly mer Synthesis: Formation of Palladium Complexes and Their Catalytic Properties in the Hydrogénation of Olefines. Z. Keda, D. C. Neckers 4:50—179. Thiophenes Complexation with Metal Carbonyls and Their Subsequential Oxidation Products. T. Dennis, D. C. Neckers
MONDAY EVENING Shideler, Room 115 Symposium on Organic Chemistry—I. Synthesis of Molecules of Theoretical Interest J. Sebastian, Presiding 6:30—180. Recent Developments in the Synthesis of Unusual Polycyclic Hydrocarbons. L. A. Paquette 7:30—181. Pyramidal Alkenes and Carbonyls. K. N. Houk 8:30—182. Non-Kekule' Compounds and the Domain of Hund's Rule. J. A. Berson
TUESDAY MORNING Shideler, Room 115 Symposium on Organic Chemistry—II. Synthesis of Natural Products
R. Parker, Presiding 9:00—183. Total Synthesis of Polyether lonophore Antibiotics and Analogs. R. E. Ireland 10:00—184. Recent Progress in the Total Synthesis of Natural Products. P. A. Grleco 11:00—185. New Approaches to Natural Product Synthesis. W. C. Still
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Make check payable to: ACS-15th CRM, and mail with registration form to: Alan Isaacson, Chemistry Department, ACS-15th CRM, Miami University, Oxford, Ohio 45056 April 11, 1983 C&EN 57
Meetings TUESDAY AFTERNOON Shideler, Room 10 General Session on Synthesis of Natural Products—I
R. T. Taylor, Presiding 2:00—186. Approach to the Chiral Synthesis of Pleuromutilin. Part 1. Total Synthesis of a Key Degradation Product. P. Wiedeman, P. C. Page, L A. Paquette 2:20—187. Approach to the Chiral Synthesis of Pleuromutilin. Part 2. Elaboration of the Natural Product. P. C. Page, L. A. Paquette 2:40—188. Studies Directed Toward a Chiral Synthesis of (-)-Retigeranic Acid. R. A. Roberts, L. A. Paquette 3:00—189. Total Synthesis of the Alleged Structure of Senoxydene. R. Gaiemmo, L. A. Paquette 3:20—190. Synthesis of Cyclopentanoid Compounds. R. K. Zoll, D. J. Ager 3:40—Intermission 3:50—191. Synthesis of Optically Active Cyclopentanoids from Ribose. C. E. McDonald, R. W. Dugger 4:10—192. Approaches to Axisonitrile. P. Y. Johnson, R. Laiter 4:30—193. Tandem Diels-Alder-FriedelCrafts Approach to the Anthracyclines. G. A. Kraus, M. D. Hagen 4:50—194. Diels Alder Reactions of Fluorinated Cyclobutenes. T. H. Kinstle, D. Loo, D. W. Beight 5:10—195. Chiral Precursors for Total Syn thesis Via Enzyme Catalyzed Asymmetric Reactions on Prochiral Substrates. D. W. Brooks, H. Mazdiyasni, N. C Lee, M. Wilson
9:00—203. Mechanism for the Photolysis of Parathion. J. R. Grunwell, D. E. Doster 9:20—204. Rose Bengal Derivatives as Sensitizers. J. Lamberts, D. C Neckers 9:40—205. Benzo[b]thiophene Derivatives as Photochemical Initiators of Polymer ization. F. Wagenaar, D. C Neckers 10:00—206. Photochromic Behavior of Some Crosslinked Polymers. S. Kumar, M. Saffran, C Savariar, D. C Neckers 10:20—Intermission 10:30—207. Deuterium Exchange in Some Substituted Norborneols. G. B. Clemans, J. G. Samaritoni, G. K. Strohl 10:50—208. Enthalpy of Nucleophilic Addition to Amines to Enenitriles. J. E. Hinners, T. Kruger 11:10—209. Protonation of Anion Interme diates in Metal-Ammonia Reduction: 1,2vs. 1,4-Dihydroaromatic Products. P. W. Rabideau, D. L. Huser 11:30—210. Oxygen Trapping of Laser-gen erated Biradicals to Form Peroxides Related to Postaglandins. R. M. Wilson, D. L. Moats, R. Ranganathan, T. T. Conrad, K. Schnapp 11:50—211. Sources of Polycyclic Aromatic Hydrocarbons and Their Impact on the En vironment. V. K. Gupta
TUESDAY MORNING Shideler, Room 10 Symposium on Physical Chemistry. High Resolution NMR of Solids: Techniques and Applications—I
J. Yesinowski, Presiding 9:00—226. High-Resolution NMR of Solids. E. Oldfield 9:55—227. Si-29 and C-13 MAS-NMR of Solid Polymers. W. M. Ritchey, D. Cory, A. Cholli 10:50—Intermission 11:05—228. Magic Angle Spinning of Quadrupolar Nuclei. J. L. Ackerman, R. G. Pratt
MONDAY AFTERNOON Shideler, Room 215 General Session B. S. Ault, Presiding
Shideler, Room 10 General Session on Physical Organic Chemistry
6:30—220. Phase Transition Behavior in Crystalline and Amorphous ZirconiumPalladium Hydrides. R. C. Bowman Jr., D. E. Etter, A. Attalla, J. S. Cantrell, J. E. Wagner 6:50—221. NMR Spectrometer for Biophys ical Studies. R. J. Wittebort, N. P. Kulshreshtha, S. E. Woehler, C A. Bradley 7:10—222. Study of Surface Chemical Species Via Solid State NMR. H. B. Ragle, J. L. Ackerman 7:30—Intermission 7:50—223. 29 Si NMR Study of Crosslinked Networks. K. Beshah, J. E. Mark, J. L. Ackerman, A. Himstedt 8:00—224. Nitrogen-14 NMR in Solids with Magic Angle Spinning. R. G. Pratt, J. L. Ackerman 8:20—225. Applications of Variable Tem perature Magic-Angle Spinning NMR in Solids. M. J. Sullivan
PHYSICAL CHEMISTRY
Hughes, Room 150 General Session on Synthesis of Natural Products—II J . Belletire, Presiding 7:00—196. Chiral Intermediate from Limonene Oxide. D. L. Johnson, J. G. Galloway, R. T. Taylor 7:20—197. Progress Towards the Total Synthesis of Tirandamycin. R. W. Dugger 7:40—198. Studies Towards the Synthesis of lonophores. D. J. Ager 8:00—199. Photoinduced Diels-Alder Reac tions of Substituted Cycloheptenones. E. W. Long, R. W. Dugger 8:20—Intermission 8:30—200. Cycloaddition Reactions of Con jugated Nitrones. T. H. Kinstle, M. G. Ranasinghe 8:50—201. Stereochemical Aspects of S0 2 Photoextrusion to Form β-Lactams. L. R. Sousa, M. J. Fazio, A. M. Gargoum, L. L. Nelson 9:10—202. Alkaloid Characterization by Di rect Mixture Analysis Using MS/MS. Κ. Ε. Singleton, R. G. Cooks, B. Meyer, N. Ferrigini, J. L. McLaughlin MORNING
Hughes, Room 153 General Session F. S. Ezra, Presiding
J. P. Yesinowski, Chairman
TUESDAY EVENING
WEDNESDAY
MONDAY EVENING
2:00—212. Spectroscopic Determination of the Crystal Structure of Dimethyltin Dichloride. J. M. Landry, J. E. Katon 2:20—213. Vibrational Spectra and Structure of Oxaloacetic Acid (2-Oxobutanedioic Acid). D. W. Schiering, J. E. Katon 2:40—214. Variation of Infrared Molar Ab sorptivity with Temperature. S. R. Lobo, J. E. Katon 3:00—215. Oxide Salt Reactions in Matrix Isolation Studies: Infrared Spectra of the TI2+SO3 2 - and T1 2 + S 2 0 5 2-Triple Ions. S. J. David, B. S. Ault 3:30—Intermission 3:30—216. Matrix Isolation Investigation of Molecular Complexes of SiF4 with Oxy gen-Containing Bases. B. S. Ault 3:50—217. Linear Dichroism of Polymer Films Using a Polarization-Modulation FTIR Technique. C. Marcott 4:10—218. Orientation and Mobility in Mobile, Uniaxially Stretched Elastomer Networks Studied by Fluorescence Polarization. J. P. Queslel, L. Monnerie 4:30—219. Low Temperature and Ambient X-ray Diffraction (XRD) Studies of Zircon ium Hydrides for ZrH^soi to ZrH 19 9 7 . J. S. Cantrell, R. C Bowman Jr., D. E. Sullenger
TUESDAY AFTERNOON Shriver Center Towers Symposium on Physical Chemistry. High Resolution NMR of Solids: Techniques and Applications—II 2:00—229. Two-Dimensional NMR in Rotating Solids. M. G. Munowitz, W. P. Aue, D. J. Ruben, R. G. Griffin 2:55—230. 13C NMR Studies of Solid-State Dynamics in Metal Carbonyls. Β. Ε. Han son, H. C. Dorn, E. Motell 3:05—Intermission 4:05—231. 19F MAS-NMR of Fluoridated Hydroxyapatite Surfaces. J. P. Yesinowski, R. A. Wolfgang, M. J. Mobley WEDNESDAY
MORNING
Shideler, Room 215 General Session J . S. Cantrell, Presiding 9:00—232. Acid-Catalyzed Self-Condensa tion Reactions of /3-Diketones Monitored by LC-1H NMR. J. T. Roy, H. C. Dorn 9:20—233. p-Fluorobenzoyl Chloride—a New 19 F NMR Tagging Reagent. M. P. Spratt, H. C. Dorn
R. Dugger, Presiding
Calls for papers The 1983 Pacific Conference on Chem istry & Spectroscopy will be held at the Pasadena Hilton in Pasadena, Calif., Oct. 26-28. It will be sponsored by the Southern California Section of the Soci ety for Applied Spectroscopy, and the ACS Southern California Section. Addi tional sessions will be sponsored by the Association of Southern California Crystallographers. Papers are solicited in the following general and specific topic sessions: Ana lytical Applications of Lasers; Analytical 58
April 11, 1983 C&EN
Chemistry; Atomic Emission Spectros copy; Atomic Fluorescence Spectroscopy; Audiovisual Presentations in Analytical Techniques; Bioinorganic Reaction Mechanisms; Catalysis, Metal Clusters, and the Heterometallic Bond; Chemical Basis for the Origin of Life; Chemistry at Electrodes; Computers in (a) Chemical Education, (b) Laboratory Data Acquisi tion, (c) Spectroscopy; Control of Haz ardous Wastes in the Academic Envi ronment; Environmental Spectroscopy; Extra-Terrestrial Geochemistry; Fluo rescence Spectroscopy; Forensic Chem istry; Fourier Transform Infrared Spec
9:40—234. Oxygen-17 NMR Study of Iso meric 2-R-2-oxo-1,3,2-dioxaphosphorinanes. P. L. Bock, J. A. Mosbo, J. L. Redmon 10:00—235. Proton Magnetic Resonance Study of Alkali Metal Salt Solvation In 1,1,3,3-Tetramethylurea. L. A. Mann, B. J. Barker 10:20—Intermission 10:30—236. Quantum Chemical Studies of Bonded and Nonbonded Interactions. A. Chung-Phillips, K. H. Aufderheide 10:50—237. Practical Methods for the Cal culation of Resonance Lifetimes. A. D. Isaacson 11:10—238. Photo-Kolbe Studies of Aromatic Acids Using Platinized Magneli Phases of TiOx. J. S. Cantrell, P. Nagy, K. Bertke, R. Felland 11:30—239. Gas Phase DisproportionationCombination Rate Constant Ratios for Halocarbon Radicals. D. J. Rakestraw, B. E. Holmes 11:50—240. Temperature-Dependent Single vs. Double Ionization in the Mass Spectra of Phthalocyanine and Its Metal(ll) Com plexes. S. M. Schildcrout
TECHNICIAN AFFILIATES R. J. Sunberg, Chairman TUESDAY MORNING & AFTERNOON Hughes, Room 153 9:00—Introductory Remarks. R. A. Sunberg 9:10—241. Professional Technicians—an Important Resource. R. A. Libby 9:20—242. Application of Electron Beam X-ray Microanalysis to Biological Tissues. M. C. Myers, R. R. Warner 9:40—243. Differentiation of Saturated and Unsaturated Lipids on High Performance Thin Layer Chromatograms. G. J. Kramer 10:00—244. New 19F MAS-NMR Methods for the Quantitation of Calcium Fluoride, Fluoroapatite, and Fluorohydroxyapatites on Hydroxyapatite Surfaces. R. A. Wolfgang, J. P. Yesinowski 10:20—Intermission 10:40—245. Total Synthesis of (2S,3S)-3N - L - Aspartyl - 2 - Hydroxy-6-Methylheptane—a Novel Aspartic Acid Amide Sweetener. R. A. Echler, G. P. Rizzi. 11:00—246. Robotic Sample Preparation Station. R. J. Eckstein, G. D. Owens 2:00—247. Chemical Technicians: Prepara tion for Job and Career. F. J. Kryman 2:20—248. Chemistry of Arson Analysis. L. Meal 2:40—249. Calcium Salt of 3-Amino-1-Hydroxypropane-1, 1-Diphosphonate (3-APD): A Gelatinous Diphosphonate of Therapeutic Value. R. J. Sunberg, J. J. Benedict 3:00—250. Effects of Diphosphonates on Tumor-Induced Hypercalcemia and Os teolysis in Walker Carcino Sarcoma 256 (W-256) of Rats. M. A. Wesseler, K. Y. Johnson, R. R. Martodam, H. M. Olson, J. W. Poser 3:20—251. Diphosphonate Inhibition of Post-Dental Extraction Bone Loss in Beagle Dogs. J. Huesman, H. M. Olson 3:40—Closing Remarks. R. A» Sunberg
troscopy; High Performance Liquid Chromatography; Hyphenated Tech niques; Inorganic Chemistry; Mass Spectrometry; Mechanisms of Enzyme Reactions; Molecular Dynamics in Solu tion; Nuclear Magnetic Resonance; Or ganic Chemistry; Photoacoustic Spec troscopy; Photochemical Energy Con version; Physical Chemistry; Raman Infrared & Spectroscopic Applications; Recombinant DNA Techniques; Reflec tance Analysis; Sample Introduction for Atomic Techniques; Surface Analysis Techniques; Synthetic Organic Chemis try; UV-VIS Spectroscopy; X-Ray Crys-
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tallography (a) Recent Developments in Hardware, (b) Structure Determinations; X-Ray Fluorescence Spectroscopy. Authors who wish to present papers on any of the above topics should submit an abstract (150 to 200 words) to a program chairman listed below. All abstracts will be reproduced by the photo offset pro cess. The standard ACS abstract form, which is available upon request, should be used. All abstracts must be submitted by June 15. The program chairmen are: (ACS) David L. Toppen, Dept. of Chem istry, California State University, Northridge, Calif. 91330, Tel. (213) 8852064; for SAS: Robert Obremski, Beckman Scientific Instruments Div., Campus and Jamboree, Irvine, Calif. 92713, Tel. (714) 833-0751.
The ACS 35th Southeastern Regional Meeting will be held in Charlotte, N.C., on Nov. 9-11. The Carolina-Piedmont Section will be hosting the meeting. The program organizers have obtained an exceptional group of speakers. Speakers coming from abroad for the event in clude D. Moebius and K. Zacharisse (Goettingen), C. Giannotte (CNRS-Gif), A. Levasseur (Bordeaux), Mitsuo Abe (Tokyo), and D. H. Williams (Cam bridge). Papers are being solicited in the fol. lowing general technical sessions: Ana lytical Chemistry, Biochemistry, Chem ical Education, Computers in Chemistry, Environmental Chemistry, History of Chemistry, Inorganic, Medicinal, Nu clear, Organic, Physical, Polymer, Pesti-
cide & Agricultural Chemistry, and Un dergraduate Chemistry. In addition to the general sessions and invited symposia, there will be a chemi cal exposition, three workshops—CAS Search Service Workshop, HPLC Trou bleshooting Workshop, and ChemCom Workshop—an employment clearing house, and special social events. Abstracts of papers must be submitted on standard ACS forms to the program chairman by June 30. Communications or requests for abstracts forms or other in formation may be obtained from the program chairman, Felix A. Carroll, SERMACS-35, P.O. Box 856, Davidson, N.C. 28036. D
ganic chemistry section of the National Science Foundation is providing a block travel grant of roundtrip airfares for U.S. participants. Anyone wishing to be con sidered for a travel award should apply immediately to: Christopher A. Reed, Chemistry Department, University of Southern California, University Park, Los Angeles, Calif. 90089-1062. The deadline for receipt of applications is April 29. For information about ICBIC write to: Prof. Andrea Scozzafava, Inst, di Chimica Générale ed Inorganica, Via Gino Capponi 7, 50121 Florence, Italy. D
FEBS offers placement service for biochemists Travel awards to ICBIC in Florence, Italy The first International Conference on Bioinorganic Chemistry (ICBIC) will be held in Florence, Italy, on June 13-17. The scientific program consists of plenary and session lectures, minisymposia, and round-table discussions, together with a large and varied program of poster ses sions. Contributions are expected to span the entire range of interactions of metal ions with molecules of biological in terest. The meeting has numerous Italian sponsors as well as the International Union of Pure & Applied Chemistry and the International Union of Pure & Ap plied Biophysics. In addition, the inor-
The Federation of European Biochemical Societies (FEBS) is organizing a job placement bureau at its 15th FEBS Meeting this year in Brussels on July 24-29. This is a new scheme for FEBS. "The best way the federation can help young biochemists is to find them jobs," said the organizing chairman Claude Liebecq. Applications will be received from employers and from job applicants. All will be required to register for the meeting and to pay a moderate additional fee to cover the cost of the service. Persons who are interested in using the job placement service should contact J. P. Perraudin, c/o 15th FEBS Secretariat, Brussels International Conference Centre, Parc des Expositions, B-1020 Brussels, Belgium. D
Letters Continued from page 4
claimed a 1011 acceleration for the overall second order acylation of the model due to all effects of complexation, which is what we ob served. Trainor and Breslow's (see above reference) highest rate accelerations are based on a com parison of the rate at which substrate hydrolyzes in 60% dimethyl sulfoxide—40% water, and the rate at which substrate complexed with /3-cyclodextrin acylates one of its seven secondary hydroxyl groups. The states of ref erence for their catalyzed system are com plexed substrate and the rate-limiting transi tion state for acyl transfer within the complex. For their uncatalyzed system, the reference states are substrate and water (presumably at activity one) for the two reactants, and the rate-limiting transition state for hydrolysis. Their resulting rate acceleration is ~3 X 106. Their association constant for complex for mation is 2.6 Χ 102. An estimate of their rate acceleration due to both collection and orienta tion normalized from seven to single hydroxyl
group is about 108. More of their overall rate acceleration is due to orientation rather than collection, so their system is particularly ef fective at high concentrations. Of our 1011 rate acceleration, more is due to collection than to orientation, so our system is particularly ef fective at low concentrations. Another difference in our approaches is noteworthy. Breslow has tailored the substrate to fit the enzyme model, whereas we have tailored our enzyme model to fit the substrate. The problems and opportunities for their so lution in this field are so vast that all possible approaches are welcome. Donald J. Cram, University of California
Our high/low achievers SIR: The Feb. 28 issue of C&EN contains two items which cannot be passed by without a comment. First we learn (page 39) that the ac ademic gap between high and low achievers in math and science is closing, but only be-
cause the scores of the high achievers are falling. To those of us without emotional ties to the National Education Association, whose only link to professional education has been watching our children go through school, the explanation is clear. Each generation of inadequately-trained math and science teachers produces a new generation of students trained even more poorly. Some of those students unfortunately become the next generation of teachers. Now Senators Domenici and Glenn (page 36) want to subsidize this process with federal money. While our subsidized secondary school teachers are getting their training, will the emphasis be on math and science, or will it be on educational methodology? After a few years we will discover a surplus of poorlytrained math and science teachers, the federal budget will have another uncontrollable item, and the "educators" will have a little more turf to protect. Only the children and the nation will suffer. H. L. Arons, Ramsey, N.J. April 11, 1983 C&EN
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