J, Agric. Food Chem. 1995, 43, 235-240
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Metabolism of Pyriproxyfen in Rats. 1. Absorption, Disposition, Excretion, and Biotransformation Studies with [phenoxyphenyl-14C]Pyriproxyfen Haruyuki Matsunaga, Hiromi Yoshino,” Naohiko Isobe, Hideo Kaneko, Iwao Nakatsuka, and Hirohiko Yamada Environmental Health Science Laboratory, Sumitomo Chemical Company, Ltd., 1-98 3-Chome, Kasugade-Naka, Konohana-Ku, Osaka 554, J a p a n
Male and female rats were given a single oral dose of [phen~xyphenyl-~~CIpyriproxyfen L4-phenoxyphenyl (R,S)-2-(2-pyridyloxy)propylether] at 2 (low dose) or 1000 (high dose) mg/kg. 14Cwas rapidly excreted into feces and urine, with the former route predominating (about 90% of the dose). Peak 14C concentrations in blood, kidney, liver, and other tissues except for fat occurred 2-8 h after administration, being 0.4, 0.4, 2.5, and
