Chemical Education Today
Letters Modification to Synthesis of Methyl Diantilis After we published the “Synthesis of Methyl Diantilis, a Commercially Important Fragrance” (1), we encountered a problem with the catalyst, Amberlyst-15, used in the second step. It appears that in some cases soluble acid impurities wash off of the solid catalyst and decompose the final product when the solvent is removed. This problem is solved by adding 0.5 g of sodium bicarbonate before the final filtration. The revised laboratory procedure that includes this change has replaced the original supplement available at JCE Online (2). Literature Cited 1. Miles, W. H.; Connell, K. B. J. Chem. Educ. 2006, 83, 285– 286.
2. Synthesis of Methyl Diantilis, a Commercially Important Fragrance; http://www.jce.divched.org/Journal/Issues/2006/Feb/ abs285.html (accessed May 2008).
Supporting JCE Online Material
http://www.jce.divched.org/Journal/Issues/2008/Jul/abs917_1.html Full text (HTML and PDF) with links to cited JCE article Supplement
Instructions for the students and notes for the instructor (revised to reflect the change in procedure) William H. Miles Department of Chemistry Lafayette College Easton, PA 18040
[email protected] © Division of Chemical Education • www.JCE.DivCHED.org • Vol. 85 No. 7 July 2008 • Journal of Chemical Education
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