Environ. Sei. Technol. 1907, 21, 815-820
Adams, D. F.; Farwell, S. 0.;Robinson, E.; Pack, M. R. BPRI Report EA-1516,Project 856-1;Washington State University: Pullman, WA, 1980. Grosjean, D. Environ. Sci. Technid. 1985, 19, 1059-1065. Goldan, P.D.; Kuster, W. C.; Albritton, D. L. Atmos. Enuiron. 1986, 20, 1203-1209. Goldan, P.D.;Kuster, W. C.; Albritton, D. L.;Fehsenfeld, F. C. J. Atmos. Chem., in press.
Literature Cited Ingvorsen, K.; Jorgensen,B. B. Atmos. Environ. 1982,16, 855-865.
Hansen, M.H.;Ingvorsen, K.; Jorgensen, B. B. Limnol. Oceanogr. 1978, 23, 68-76. Delmas, R.; Baudet, J.; Servant, J.; Baziard, Y. J. Geophys. Res. 1980,85, 4468-4474. Adams, D. F.; Farwell, S. 0.; Pack, M. R.; Robinson, E. J. Air Pollut. Control Assoc. 1981. 31. 1083-1089. Carroll, M. A. Ph.D. Thesis, MIT, 1983. Hill, F. B.; Aneja, V. P.; Felder, R. M. J. Enuiron. Sci. Health, Part A 1978, A13, 199-225. Steudler,P. A.; Peterson,B. J. Nature (London) 1984,311, 455-457.
Received for review March 25, 1986. Accepted April 10, 1987. This reasearch was supported by NOAA as part of the National Acid Precipitation Assessment Program.
Mutagenic Activity Associated with Cooling Tower Waters Treated with a Biocide Containing 5-Chloro-2-methyl-4-isothiazolin-3-onet George M. Woodall,$ Oscar C. Pancorbo,*-§R. Dean Blevins,Il and Kenneth E. Ferslewl Department of Environmental Health and Department of Health Sciences, School of Public and Allied Health, and Department of Pharmacology, Quillen-Dishner College of Medicine, East Tennessee State University, Johnson City, Tennessee 376 14, and Environmental Health Science Program, Department of Food Science and Technology, The University of Georgia, Athens, Georgia 30602
With the Ames Salmonella-mammalian microsome test, significant mutagenic adivity was detected in coolihg tower water shortly (same day) after treatment with a biocide (CL2150) containing 5-chloro-2-methyl-4-isothiazolin-3-one (5-chloro-IT). Dose-related mutagenic responses with TA97 ( 4 9 ) and TAlOO (-S9) were produced with the acid fraction (extracted at pH
