N-Nitroso-N-methylvinylamine: Reaction of the epoxide with guanyl

Osamu Okazaki, Magnus Persmark, and F. Peter Guengerich. Chem. Res. Toxicol. , 1993, 6 (2), pp 168–173. DOI: 10.1021/tx00032a005. Publication Date: ...
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Chem. Res. Toxicol. 1993, 6, 168-173

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N-Nitroso-N-methylvinylamine:Reaction of the Epoxide with Guanyl and Adenyl Moieties To Yield Adducts Derived from Both Parts of the Molecule Osamu Okazaki,+Magnus Persmark, and F. Peter Guengerich* Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146 Received October 12, 1992

N-Nitroso-N-methylvinylamine was synthesized and treated with dimethyldioxirane to produce 1-(N-nitrosomethy1amino)oxirane.1-(N-Nitrosomethy1amino)oxiranehad a tl12 of