Editorial pubs.acs.org/crt
Cite This: Chem. Res. Toxicol. 2018, 31, 1105−1105
Nanosafety Research−An Ongoing Story • exclusion of assay interference as well as inclusion of appropriate positive or negative controls (benchmark compounds and/or reference materials) • proper description of algorithms and methods used to analyze the data As a forum for publications related to all aspects of mechanisms of toxicity, with an emphasis on molecular mechanisms, and to accommodate the great activity in the field, CRT specifically encourages manuscripts related to nanosafety research.
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t the beginning of this year, I joined the editorial team of Chemical Research in Toxicology (CRT) around its Editor in Chief, Prof. Shana Sturla. My own research interests focus on the interactions of engineered nanomaterials with cells and the involved mechanisms. This comprises the biologically relevant properties of nanoobjects, their interactions with cellular structures, detection of uptake pathways and intracellular distribution, as well as biological mechanisms resulting in cellular responses. As Associate Editor, it is a great honor for me and a pleasure to participate in the advancement of this ACS journal in particular in the field of toxicological research related to nanomaterials. The research field of “nanotoxicology” differs from other toxicological fields in that it focuses on nanomaterials as the objects of investigations and their impact on human health and the environment. Generally, nanomaterials are defined by their size in the 1−100 nm size range. Various definitions exist worldwide, reflecting that there is still an ongoing debate about the actual parameters that define nanomaterials and their relation to potential hazards or risks. Nanotechnologies, comprising the fabrication of nanomaterials, are still regarded as key enabling technologies, furthering innovations in important fields like energy generation and storage, information technologies, or the diagnosis and treatment of diseases. Taking this application-oriented perspective, the term “nanotoxicology” can also be replaced by “nanosafety research”, in order to underline that one important motivation for research in this field is to build a knowledge base in order to promote the safe application of useful nanomaterials. Furthermore, an improved understanding of nanomaterial-related chemical and structural or biological mechanisms is expected be useful for the tailored design of even safer nanomaterials. During the last 10 years, nanosafety research has developed substantially. Nowadays it is probably making use of any molecular technique available, at the same time reflecting developments in the overall field of toxicology. But most importantly, it has been recognized that research in this field is truly interdisciplinary, requiring considerations of all relevant aspects ranging from materials science to molecular toxicology, thereby enabling one to capture the whole picture and to transfer results from basic research to regulation and the design of safe materials. Against this background, CRT will be adapting its guidelines towards best practices in nanosafety research beginning in 2019. These guidelines serve as reference for submitting authors as well as reviewers and summarize the basic information to be contained in original manuscripts. The guidelines underline the importance of
Annette Kraegeloh,* Associate Editor
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Views expressed in this editorial are those of the author and not necessarily the views of the ACS.
• physicochemical properties as well as system-dependent properties that are relevant to support the conclusions of the study • highlighting the relevance of the examined dose and relevance of dose measures • properties of biological test systems as well as detailed description of exposure protocols © 2018 American Chemical Society
Nano Cell Interactions, INM - Leibniz Institute for New Materials, 66123 Saarbruecken, Germany
Published: November 19, 2018 1105
DOI: 10.1021/acs.chemrestox.8b00325 Chem. Res. Toxicol. 2018, 31, 1105−1105
