Editorial pubs.acs.org/crt
Cite This: Chem. Res. Toxicol. 2019, 32, 535−535
Nanosafety: Where Are We Now and Where Must We Go? The CRT special issue ‘Future Nanosafety’ is being edited by guest-editor Prof. Harald Krug and CRT Associate Editor Dr. Annette Kraegeloh. CRT is active in promoting best practices in nanosafety research such that the physicochemical properties of nanomaterials used for research studies should be characterized appropriately to support the conclusions of biological and toxicological studies. Hence, authors and reviewers are invited to follow the CRT author guidelines (https://pubs.acs.org/ journal/crtoec). We welcome your submissions of research articles, rapid reports, perspectives, reviews, or ToxWatch articles. Authors are invited to send a presubmission inquiry to the Editors that includes an abstract and cover letter indicating the intended manuscript format by e-mail (
[email protected]). Tentative issue publication date, March 2020; tentative submission deadline, October 15, 2019.
Chem. Res. Toxicol. 2019.32:535-535. Downloaded from pubs.acs.org by 193.56.73.216 on 04/15/19. For personal use only.
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anosafety research is dedicated to the impact of nanomaterials on human health and the environment. An important motivation for this type of research is to promote the safe application of useful nanomaterials. Significant advances at the interface of nanomaterials and biological/ toxicological sciences have led to the elucidation of materials properties responsible for triggering biological responses. Likewise, biological pathways have been identified that are involved in the development of adverse outcomes or disease etiologies. However, general statements on the role of specific materials parameters in the initiation of pathways of toxicity or even predictions on the elicited response cannot easily be made. Current approaches progressively address structure− activity relationships and relevant exposure pathways to predict the hazard and exposure potential of nanomaterials along their complete life-cycle and to derive design strategies for even safer nanomaterials. Recognizing this progression of the state of knowledge and continuing important research at the nanomaterials−toxicology interface, we are pleased to highlight in two special ACS Nanosafety science collections.
Harald Krug, Guest Editor NanoCase GmbH, 9032 Engelburg, Switzerland
Annette Kraegeloh, CRT Associate Editor
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NANOSAFETY VIRTUAL ISSUE This virtual collection comprises 19 papers published during 2017 and 2018 in Chemical Research in Toxicology, ACS Nano, and Nano Letters representing notable recent developments in the field of nanosafety research. These include papers discussing toxicologically relevant materials properties of important materials classes (silica, carbon, high aspect ratio materials) in relation to their hazard potential, biological mechanisms, and life-cycle. Further articles focus on molecular mechanisms involved in the generation of biological responses as well as on the biodistribution of nanoparticles and their behavior at specific sites in the body. Perspectives are given on how insights into structure and molecular processes might be used to model structure−activity relationships and predict impacts or even to mitigate the hazard potential of specific materials. Finally, nanomedicine is one important application of nanomaterials requiring attention to safety aspects. Recent approaches in this field are covered, including immunomodulating nanomedicines for cancer treatment, and how knowledge of toxicity mechanisms might be exploited therapeutically.
INM-Leibniz-Institute for New Materials, D-66123 Saarbruecken, Germany
AUTHOR INFORMATION
Notes
Views expressed in this editorial are those of the authors and not necessarily the views of the ACS.
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SPECIAL ISSUE ON ‘FUTURE NANOSAFETY’ With a high attention toward important ongoing research aiming to better address and predict how nanomaterials properties impact on biological responses, it is our pleasure to invite you to contribute to a planned special issue of Chemical Research in Toxicology on ‘Future Nanosafety’. This special issue is aimed at highlighting up-to-date topics in nanosafety research serving the development of predictive platforms and in vitro systems and understanding of key mechanisms against the background of regulatory needs and the development of safe nanomaterials. © 2019 American Chemical Society
Published: April 15, 2019 535
DOI: 10.1021/acs.chemrestox.9b00083 Chem. Res. Toxicol. 2019, 32, 535−535
