Article pubs.acs.org/ac
Nucleoside-Based Ultrasensitive Fluorescent Probe for the DualMode Imaging of Microviscosity in Living Cells Jianping Li, Yanyan Zhang, Hua Zhang,* Xiaopeng Xuan, Mingsheng Xie, Shuang Xia, Guirong Qu, and Haiming Guo* Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007, China S Supporting Information *
ABSTRACT: Microviscosity changes of living cells have a farreaching influence on diffusion and movement capacity of RNA and, more seriously, could modify RNA functions in living cells. Fluorescent rotor, whose fluorescence responds to different environmental viscosities, holds great potential for the imaging of viscosity in biosystem. Although many fluorescent rotors have been reported for viscosity, the fluorogenic rotor with ultrasensitivity for the determination of microviscosity (
