Our new 2-step process* makes available many more substituted

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Our new 2-step process makes available many more substituted indoles than the 20 we had previously reported!* The overall yields obtained present opportunities for expanded use of these versatile intermediates in industry. Now, a substantial number of substituted indoles can be made readily available in commercial quantities. Roche invites inquiries relative to specific needs on company letterhead. Write or call J. W.Crossinat (201 ) 235-2474, Commercial Development Department, Hoffmann J N La-Roche Inc., Nutley, N.J. 07110.

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*U.S. Patent No. 3,732,245. *"A New Indole Synthesis" by W. Leimgruber and A. Batcho. Abstracts of the Third International Congress of Heterocyclic Chemistry, Sendai, Japan, August 23-27,1971. (Reprints available upon request.)

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C&EN Jan. 28, 1974