Conclusions The field of 2D separation is in its infancy, with only a handful of tech niques so far developed out of thou sands of possibilities. The enormous resolving power of 2D separation com bined with these uncharted methodol ogies suggests that 2D research and development may become a major ele ment in advancing the field of analyti cal separations. However, 2D research faces different problems and is likely to follow a path somewhat different from that of I D research. Clearly, any 2D technology must stand on the shoulders of ID building blocks. Whereas the thrust of ID re search is to improve the building blocks, the thrust of 2D research will be to find powerful and ingenious ways of combining known building blocks. Rather than developing new or more effective ID displacement phe nomena, the 2D researcher will face an enormous, fertile field that is rather well staked out by extended matrices based on known ID techniques. Sig nificant progress will depend on a ju dicious choice of building blocks, the development of effective means for their combination, system optimiza tion, and the development of sophisti cated detection and data reduction systems. Given due attention, the possibilities are almost endless.
This investigation was supported by Public Health Service Grant GM 10851-27 from the Na tional Institutes of Health. References (1) Consden, R.; Gordon, A. H.; Martin, A. J. P. Biochem. J. 1944,38, 244. (2) Haugaard, G.; Kroner, T. D. J. Am. Chem. Soc. 1948, 70, 2135. (3) Durrum, E. L. J. Colloid Sci. 1951,6, 274. (4) Guiochon, G.; Gonnord, M.-F.; Zakaria, M. Chromatographic! 1983,17,121. (5) Zakaria, M.; Gonnord, M.-F.; Guio chon, G. J. Chromatogr. 1983, 271,127. (6) O'Farrell, P. H. J. Biol. Chem. 1975, 250, 4007. (7) Scheele, G. A. J. Biol. Chem. 1975,250, 5375. (8) Anderson, N. G.; Anderson, N. L. Anal. Biochem. 1978,85,331. (9) Jellum, E. "Advances in Chromatogra phy"; Zlatkis, Α., Ed.; Elsevier: Amster dam, the Netherlands, 1982; p. 139. (10) Guiochon, G.; Beaver, L. Α.; Gonnord, M.-F.; Siouffi, A. M.; Zakaria, M. J. Chromatogr. 1983, 255, 415. (11) Wankat, P. C. AIChE J. 1977,23, 859. (12) Giddings, J. C. "Dynamics of Chro matography"; Marcel Dekker: New York, N.Y., 1965. (13) Giddings, J. C. In "Treatise on Ana lytical Chemistry"; Kolthoff, I. M.; Elving, P. J., Eds.; John Wiley: New York, N.Y.. 1981; Part I, Chapter 3, p. 63. (14) Giddings, J. C; Keller, R. A. J. Chro matogr. 1959,2,626. (15) Fisher, R. B.; Parson, D. S.; Morrison, G. A. Nature 1948,161, 764. (16) Giddings, J. C. Anal. Chem. 1967, 39, 1927.
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(17) Wankat, P. C. Sep. Sci. Technol. 1984,19, in press. (18) Svensson, H.; Brattsten, I. Ark. Kemi 1949,/, 401. (19) Grassmann, W.; Hannig, K. Naturwissenschaften 1950,37, 397. (20) Strain, H. H.; Sullivan, J. C. Anal. Chem. 1951,23,816. (21) Myers, M. N.; Giddings, J. C. Powder Technol. 1979,23, 15. (22) Martin, A. J. P. Discuss. Faraday Soc. 1949 7 332 (23) SÔ\ms, Ï. Helu. Chim. Acta 1955,38, 1127. (24) Giddings, J. C. Anal. Chem. 1962,34, 37.
J. Calvin Giddings is professor of chemistry at the University of Utah, where he earned his PhD in 1954. His interests include field flow fractionation, macromolecular separations, the theory of separations, chromatography theory, environmental science, and world population and resource problems.
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1270 A · ANALYTICAL CHEMISTRY, VOL. 56, NO. 12, OCTOBER 1984
