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J . Calvin Giddings dies at 66 T°e J°urna' re_ J
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worked closely with Giddings for over 30 years. "He spent the time in a motel room, and by the time he went home, he had the basic concept all worked out," said Myers. "Cal had a lot of enthusiasm, no matter what he was doing. There was always a constant flow of ideas from him. One conversation could give you 10 years worth of ideas to work on." Giddings authored or co-authored more than 400 publications, including Unified Separation Science, , graduate text tn tth fundamentals of separation science, and Dynamics of Chromatography, considered d classic in the field. He founded the journal Separation Science and Technology in 1919 and served as its executive editor for 30 years. In 1965, Giddings recognized the need for periodic reviews of the field of chromatography and started the Advances in Chromatography yeries ,erving aa Executive Editor until 1993. "Cal was a fastidious editor very meticulous He wanted cutting edge [material for the series ] cine! WJIS cH~
NEWS FROM FACSS IN KANSAS CITY As reported by Celia M. Henry
Raman spectra of breast tissue
One of the most nerve-wracking, heartwrenching experiences in a woman's life is the time spent waiting for the results of a breast biopsy to determine whether she thp a™ nf fifi pftpr has cancer. Most diagnoses require surgical removal of breast tissue, and more than 80% of breast biopsies reveal that Giddings, a theoretical chromatograsuspect growths are benign. However, pher, was best known for inventing fieldRaman spectroscopy may allow the rapid, flow fractionation (H , l , ),a family of chrominimally invasive, and qualitative diagnomatography-like eluuon techniques in 1 1 . 1 J- 1 1 V x. x. sis of breast cancer. which an external field or gradient, rather Two presentations at FACSS focused on than partitioning between phases, causes the potential use of Raman spectroscopy for differential retention. FFF is applicable to the diagnosis of breast cancer. Douglas C. problems in fields ranging from medicine Redd of the University of Pennsylvania to fabncation to environmental studies. GidMedical Center, who says that he is a "clinician looking for a better tool", has worked ahead of the times " said Phvllis with Richard L. McCreery of Ohio State Brown professor of chemistry at the Uni6 -i-J-t o 1 " * Tj*L?T_T University to use Raman to characterize versity of Rhode Island and one of the curbreast tissue taken from mastectomy and rent editors for the Advances series "Cal's x i n . , U C i O l V l U V / t l V/X X X X v v c i o VJV^ v \ - . i v y ] j v , » _ l excisional biopsy patients. ability to see new talent was a tremendous on a rained-out trip to Yeuowstone iNaasset and the science of separatinn has lost Redd attributed a signature spectrum a pionppr in the fielrl " iviarcus iviyers, a researcii colleague wiio of normal breast tissue, despite slight site variability, to carotenoids and oleic acid methyl ester. Cancerous tissue lost the signature spectrum and gained additional peaks at approximately 1450 cm -1 , which are attributable to type I and type II collagen. Although all analysis to date has been of excised tissue, he said that they hope to use a fiber-optic needle probe that has one excitation fiber and one collection fiber to diagnose breast cancer without a biopsy. Patrick J. Treado of the University of Pittsburgh presented two clinical Raman imaging studies. One involved the investigation of polyester inclusions in human breast tissue. The research was performed by Michael Schaeberle, a graduate student at Pitt, in collaboration with Vic Kalasinsky of the Armed Forces Institute of Pathology. The second study, performed by Nicole Kline in Treado's group, involves the use of Raman imaging histopathology to detect The 1996 Heinrich Emanuel Merck Award was presented to D. Jed Harrison of the breast cancer disease states by visualizing University of Alberta (Canada) (second from right) and Andreas Manz of Imperial College changes in the lipid and protein compo(U.K.) (Second from left) during the opening ceremony of Euroanalysis IX in Septemberr.he nents of breast tissue without the use of Merck Award, one of the most prestigious prizes in analytical chemistry, ,i given every three dyes or stains. Multivariate image analysis years to a scientist under the age of 45 and carries a monetary award of 25,000 DM. Harrison was used to enhance image contrast and to and Manz were honored for their pioneering work in micromachining a miniaturized CB -based quantitate analyte distribution. chemical analysis system on a chip. The award was presented to Manz and Harrison by Treado believes that for Raman-imaging Hans-Eckart Radunz (left), general manager of Merck's Analytical lnstitute, and Manfred Grasserbauer (right), chair of the Merck Award Commiitee. spectroscopy to compete with existing diags ,p sor of chemistry at the University of
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Analytical Chemistry News & Features, December 1, 1996
