Potential Anticancer Agents. II. Urethan-Type Nitrogen Mustards of

Potential Anticancer Agents. II. Urethan-Type Nitrogen Mustards of ...https://pubs.acs.org/doi/pdfplus/10.1021/jm00314a009by I Niculescu-Duvaz - ‎19...
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CHO, u ~ 1735 = ~ cm-'. The position of OH group stretvhirig baritls in the range of 3320-3400 mi-' alio iupports the Structures attributed by US to the deiivativcs I-TII. ho~vrii t i Tablc 11, the ult raviolet spectra :ilso peri i i i t t he diffeientiation between 3 - arid 17-substituted deriratives of estrogens, ab the S,S-bis(khloroethy1)cwbamoyl group in the 3 position causes a coristaiit shift of about 10 nip toward shorter wavelengths. Biological Activity.-The antitumor activity of androsterone derivatives I and I1 is shown in Table 111. Tho wtivity of t h c (+trog(lti tlcrivzt ives w:ic:tcitC(1 0 1 1 mts bearing Walker 2.56 carcino6arconia (doses of 50 ing/l