Targeted Delivery of Nanoparticles to Ischemic Muscle for Imaging

Dec 30, 2010 - Lan Cao,. †. Dmitry Shvartsman, Eduardo A. Silva, and David J. Mooney*. School of Engineering and Applied Sciences and Wyss Institute...
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LETTER pubs.acs.org/NanoLett

Targeted Delivery of Nanoparticles to Ischemic Muscle for Imaging and Therapeutic Angiogenesis Jaeyun Kim,† Lan Cao,† Dmitry Shvartsman, Eduardo A. Silva, and David J. Mooney* School of Engineering and Applied Sciences and Wyss Institute, Harvard University, Cambridge, Massachusetts 02138, United States

bS Supporting Information ABSTRACT: Targeting of nanoparticles to ischemic tissues was studied in a murine ischemic hindlimb model. Intravenously injected fluorescent nanoparticles allowed ischemia-targeted imaging of ischemic muscles due to increased permeability of blood vessels in hypoxic tissues. Targeting efficiency correlated with blood perfusion after induction of ischemia and was enhanced in early stages of ischemia (