Template-directed interference footprinting of protein-guanine contacts

Jun 1, 1991 - Template-directed interference footprinting of cytosine contacts in a protein-DNA complex: potent interference by 5-aza-2'-deoxycytidine...
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J. Am. Chem. SOC.1991,113, 5104-5106

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Acknowledgment. We thank John Schellman and Hong Qian, University of Oregon, for discussion and for use of their computer program for the Lifson-Roig theory. This research was supported by N I H Grant G M 31475. J. M. Scholtz is an N I H fellow (GM 13451). We thank Leland V. Miller of the N I H Clinical Mass Spectrometry Resource, University of Colorado, supported by Grant R R 01 152, for FAB mass spectra and Robert J. Binard for amino acid analysis.

Scheme I

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ACAAACTTTCTTGT - upper TGTTTGT~GAACA - lower 731 oRi :-?