The Discovery of a Potent, Selective, and ... - ACS Publications


Oct 21, 2016 - Trk Inhibitor (PF-06273340) for the Treatment of Pain. Sarah E. Skerratt,*,† ... pathogenesis of inflammatory pain,1 with neutralizin...
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In this study, we report the discovery of the first potent, ... receptor tolerances at each site (Figure 1).24-27 For example, the aromatic ... (1R,2R)-trans configuration of the cyclopropane linkage is more potent than the (1S,2S)-trans and cis- ...