12 Biochemical Aspects: An Introduction GINO J. MARCO
Downloaded by TUFTS UNIV on June 3, 2018 | https://pubs.acs.org Publication Date: August 10, 1981 | doi: 10.1021/bk-1981-0160.ch012
CIBA-GEIGY Corporation, Biochemistry Department, 410 Swing Road, Greensboro, NC 27409
One of the meeting grounds of biology and chemistry is in the realm of biochemistry. In this portion of the conference, we wish to bring the toxicological concerns of pesticides into the molecular world more familiar to the chemist. In the first "transition" paper, Dr. Laishes will give a more molecular insight into the views of toxicological areas heard yesterday. Concepts already mentioned will be discussed in chemical terms on the mechanics of the carcinogenic processes as well as possible repair mechanisms. Dr. Gillette will concentrate on a most frustrating, albeit fascinating, aspect of biochemical studies, the metabolite that is there but difficult to prove; that is, the reactive intermediate. How much of a culprit is that entity in toxicological expression? I know we will get an insight on that question. The threshold concept and the pharmacokinetics involved will be addressed by Dr. Ramsey. My own prejudices suggest thresholds must exist and Dr. Ramsey will have some interesting views along those lines. In a d d i t i o n to studies on mode of a c t i o n of p e s t i c i d e s , one of the l a r g e s t biochemical e f f o r t s i n the area of p e s t i c i d e chemistry i s devoted to the metabolism o c c u r r i n g i n a v a r i e t y o f b i o l o g i c a l systems; but of most importance i n t h i s conference, the events o c c u r r i n g i n mammalian systems. Dr. I v i e has an i n t r i g u i n g overview of the metabolism area covering some of the past and present observations with some thoughts about the future e f f o r t . The future d i r e c t i o n of biochemical s t r a t e g i e s w i l l be discussed by Dr. Wright. Are there areas of biochemical s t u d i e s not addressed i n a s u f f i c i e n t manner? His comments, I'm sure, w i l l stimulate d i s c u s s i o n s and p o s s i b l y d i f f e r e n c e s of opinion. And f i n a l l y , as there are i n a l l types of s c i e n t i f i c e f f o r t , there are problems and p i t f a l l s . Those i n biochemical s t u d i e s w i l l be viewed by Dr. Waggoner. As i s o f t e n the case, posing problems and p i t f a l l s does not guarantee s o l u t i o n s . However, Dr. Waggoner w i l l provide food f o r thought and h o p e f u l l y d i s c u s s i o n s i n the meeting room as well as outside the s e s s i o n s . 0097-6156/81/0160-0195$05.00/0 © 1981 American Chemical Society Bandal et al.; The Pesticide Chemist and Modern Toxicology ACS Symposium Series; American Chemical Society: Washington, DC, 1981.
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THE PESTICIDE CHEMIST AND MODERN TOXICOLOGY
With the overlap i n our s c i e n t i f i c d i s c i p l i n e s , a c e r t a i n amount of r e p e t i t i o n i s i n e v i t a b l e ; but there w i l l be more chemical emphasis i n t h i s s e s s i o n . 1981.
Downloaded by TUFTS UNIV on June 3, 2018 | https://pubs.acs.org Publication Date: August 10, 1981 | doi: 10.1021/bk-1981-0160.ch012
RECEIVED February 9,
Bandal et al.; The Pesticide Chemist and Modern Toxicology ACS Symposium Series; American Chemical Society: Washington, DC, 1981.
